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July 19, 2002
INTERNATIONAL IMMUNIZATION NEWS
"Activity of Polymerase Proteins of Vaccine and Wild-Type Measles Virus Strains in a Minigenome Replication Assay" Journal of Virology (jvi.asm.org) (07/01/02) Vol. 76, No. 14, P. 7073; Bankamp, Bettina; Kearney, Sean P.; Liu, Xin
An intracellular, plasmid-based replication assay was recently used to compare the relative activities of five measles virus (MV) polymerase L proteins. The increased activity of polymerase L proteins from two attenuated viruses caused higher mRNA transcription levels and the production of more protein from an MV minigenome than the three wild-type L proteins. The researchers determined that the differing activity had to be a function of the L proteins alone because co-expression of wild-type L proteins with homologous N and P proteins did not differ.
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