http://www.whale.to/v/horwin1.html
No
Rights for a Child Diagnosed with Cancer
A Child has the right to…
Affection, love, and
understanding.
Adequate nutrition and medical
care.
Full opportunity for play and
recreation.
A name and nationality.
Be among the first to receive
relief in times of disaster.
Be a useful member of society and
to develop individual abilities.
Be brought up in a spirit of peace
and universal brotherhood.
Enjoy these rights, regardless of
race, color, sex, religion, national or social origin.
-
United Nations’ Declaration of the Rights of the Child Resolution 1386 XIV, 20
November 1959.
Over forty years ago, those powerful words were written and endorsed by many
nations throughout the world including the United States. It is a beautiful declaration
but sadly it is only an illusion. The medical establishment took every single
one of those rights away from our only child Alexander. Without the right to
live, there are no opportunities for affection, play, or love.
Alexander was two years old when he was diagnosed with medulloblastoma, the
most common pediatric brain tumor. This killer of children is rising in
frequency. Alexander was a strong, happy, intelligent little boy who loved
life. He enjoyed trucks and could name various types of bulldozers, backhoe’s,
garbage trucks, cranes, and tankers on sight. He had a special fascination with
airplanes and helicopters and enjoyed his visits to the airplane museum where
he could sit in the cockpit of a real helicopter and make believe he was flying.
He enjoyed being pushed in a stroller while his mommy roller-bladed behind. He
loved taking his daddy down to the boat docks to show him the little animals he
had found attached to boat-lines that had lain in the water too long. Of
course, he loved the TeleTubbies and Barney and dreamed of the day when he
would go to school wearing his little back pack, meet the real-life
"Barney’s backyard gang," and build things, make friends and play.
Alexander was a wonderful, handsome, sweet, happy child who was loved by a
large extended family. When he was diagnosed with brain cancer we turned to the
FDA and the medical profession for help. What happened next none of us could
imagine.
After two brain surgeries to remove the tumor Alexander required therapy to
ensure that the cancer would not return. We conducted around-the-clock research
to find the cancer treatment that offered Alexander the best chance to live.
After scrutinizing therapies from throughout the world, we selected the
Burzynski Clinic in Houston Texas. Burzynski, a MD Ph.D. has a twenty-year
track record of curing or controlling the re-growth of malignant brain tumors
in children and adults with an innovative cancer therapy. In addition, his
therapy is non-toxic and offers a good quality of life. The worst side effect
of his treatment is increased thirst and urination.
With this decision made we took Alexander to Houston. There, on September 21st,
1998 Burzynski met with us and then gave us the incredible news that he could
not treat Alexander. He explained that the FDA controlled his protocols and
that this regulatory organization required that Alexander first be treated with
chemotherapy and/or radiation and then have the tumor return in his brain. We
explained that our son had suffered through a total of sixteen hours of brain
surgery to be tumor free. Burzynski said his hands were tied. He explained that
Dr. Robert J. DeLap who was then Director of the Division of Oncology Drug
Products of the Center for Drug Evaluation and Research of the FDA had sent him
a letter dictating what he could and could not do. Later, through conversations
with other parents, we would learn that the FDA had actively restricted other
children from gaining access to this potentially life saving therapy.
This position by our government signed the death warrant for Alexander and
many other children. Now, instead of needing a diagnosis of brain cancer to
enter the Burzynski Clinic, the FDA was requiring that the child first receive
"standard therapies" (chemotherapy and radiation) and have
"measurable disease." This meant that a child with brain cancer must
first submit to chemo and/or radiation and have the tumor return in order to be
admitted to the Clinic. Alexander did not meet either of these two criteria and
that’s why, at the age of two, he was rejected.
Back in Los Angeles, we scrambled for other options but we were unable to
find any other viable non-toxic therapy that had any record of success with
pediatric brain tumors. We spoke with the oncologists at Children’s Hospital.
They explained that radiation was out of the question. At two-years old,
Alexander was much too young. Radiation would destroy his developing brain,
leave him with severe neurological disabilities and reduce his IQ to around 60
which would mean retardation. But they held out a life raft - chemo.
Chemotherapy, they told us, was both effective and relatively safe. Much safer
than either surgery or radiation. They told us that young children do extremely
well on chemo. They told us that without a doubt, chemo would prolong
Alexander’s life. It got even better. The doctor who would later become
Alexander’s oncologist (Doctor X) told us that having Alexander survive wasn’t
the problem. The problem was to raise him as an ordinary child. He made us
promise that we would treat Alexander normally and not show him any inordinate
attention because of his disease. The oncologist gave us what we wanted most -
hope. Yet, even with these encouraging promises we still hesitated. The idea of
filling our son’s body with poisons in order to make him healthy didn’t make
sense. We continued to pursue Burzynski’s therapy. We found that there were
several doctors who planned to use this non-toxic approach outside the USA,
beyond the reach of the FDA, but they were not up and running yet. The clock
was ticking for Alexander. Dr. X of Children’s Hospital began pressuring us to
start the chemo. We began receiving faxes and phone calls from him that
communicated his impatience with us. After more assurances from the oncologists
that their drugs would, at a minimum, "buy as time" we brought
Alexander in for his first round of chemotherapy on October 7th,
1998. Alexander sat on his mommy’s lap watching his favorite Barney video. The
nurse came in the room covered with a protective "spacesuit" that
covered her body with blue plastic from head to toe. She hooked up the bottles
labeled "biohazard" to the IV pole and connected it to Alexander’s
port-a-cath that accessed a vein near his heart. Then she started the drip. We
cried quietly as this bottle of poison emptied into our son’s body.
Since before Alexander was even born, we had done everything we could to
protect him. His mommy, Raphaele, ate healthy food throughout her pregnancy and
bore Alexander without drugs or painkillers of any kind. She breast-fed him for
four months and then made homemade baby food or bought organic baby food. His
formula was made with bottled water. He rarely ate cookies, candy or ice cream.
From day one, we made sure everything that entered Alexander’s little body was
pure, healthy and wholesome. For the first six months of his life, we had even
made his grandparents wash their hands before they touched him. And now he lay
in a hospital bed attached to an IV pole where liter bottles of poisons were
being purposefully poured into his veins. To reassure ourselves, Raphaele and I
repeated the words that the oncologists had told us. "We’re buying
time." And to Alexander we said, "This is medicine that is going to
help you."
What we didn’t know and what we couldn’t possibly know was that those words
were lies.
After the first round of chemo, Alexander began to change. Even after two
brain operations, Alexander was still a vibrant, ruddy, strong, energetic
child. But as the chemotherapy repeatedly filled his small body Alexander began
to die inside. First the relentless stomach pains and the horrendous projectile
vomiting began. Then his beautiful curly hair fell out. Next his dark skin tone
turned pale as a ghost. He got sick with fevers and spent weeks in the
hospital. Then there were the blood transfusions to replace the blood cells the
chemo had killed, the hearing tests to see if the chemo drug cisplatin
had not devastated too much of his hearing, the nuclear medicine tests to check
if Alexander’s kidneys were not giving up under the strain of processing so
much poison, the liver function tests to ensure that his liver was not being
destroyed, etc. We felt as if we were actively engaged in the slow but sure torture
of our own child.
Then we found the following statement written by Alexander’s oncologist in
our son’s medical chart. It was dated September 26, 1998:
"Dr. Z also called me
because he was very concerned about Mr. and Mrs. Horwin…He was very concerned that
the family would refuse treatment and that a court order would have to be
obtained to treat Alexander."
And on October 6, 1998 Dr. X continued:
"I think that if
Mr. and Mrs. Horwin do not bring Alexander in for chemotherapy tomorrow,
additional steps will be necessary."
We went to see an attorney to find out if the oncologists could take
Alexander from us if we decided to stop chemo. Incredibly, the answer was yes.
The lawyer explained that the court could take custody until the law decided
what to do. We weighed everything. If we said "no more chemo" to the
oncologists we knew that would get a visit from a police officer and a social
worker. Alexander would be taken from us screaming. His last days alive could
be spent out of our reach in some kind of foster care environment away from his
home, his family, his toys, everything he knew and loved while an over-burdened
legal system decided what to do with him. If we agreed to continue chemotherapy
the horrific side effects would persist but the oncologists assured us that the
treatment would prolong Alexander’s life if not save it. If we left the
country, we would have our son but no blood tests, MRI’s, or follow-up by the
surgeons who operated on him. Those were our three choices, one worse than the
next.
What do we do? We did not have a choice of therapies. Our first choice for
treatment at Burzynski’s Clinic was denied. The oncologists warned us that if
we didn’t use chemotherapy that the tumor would probably return in three
months. These doctors assured us that the chemo they were administering to our
son was the current "state-of-the-art." They told us repeatedly that
this was Alexander’s best choice for a long and healthy life.
We continued the chemotherapy. Soon Alexander’s balance was lost and his
ability to see deteriorated. When we took him home from the hospital, in
between chemo rounds, we had to give him daily injections into his legs to help
raise his blood counts that the chemotherapy had decimated. Alexander hated it.
The whole thing was horrendous.
We never stopped looking for alternatives. After three sessions of chemo, we
had found a clinic in Switzerland that had a good track record with pediatric
cancers using a non-poisonous approach. Raphaele told Alexander: "No more
chemo, Ninouche. It is finished! No more chemo or hospitals!" Alexander
was thrilled. "Yeah mommy, no more chemo," he said. This was on
December 7th, 1998.
But it was already too late. After a "clean" MRI on January 4th,
Alexander had pain in his head and back and he began to vomit. His oncologist,
Dr. X refused to do a MRI because he had done one recently and it had not shown
the return of the tumor. "Mommy I have pain here and here," Alexander
repeated constantly putting his hand on his lower back and on his head. His suffering
was increasing. We brought Alexander into the hospital on January 11th
and Dr. X ordered a CAT scan without contrast. We were told that the scan
looked "fine," although later, we would find out that a CAT scan
especially one taken without contrast is not designed to reveal the presence of
a returning brain tumor. As Alexander’s pain continued to increase, incredibly
Dr. X told us to give Alexander Tylenol and "Mountain Dew" - the soft
drink because it had caffeine for his headache. Finally, on January 18th,
we brought Alexander in to the hospital and demanded a MRI. We knew something
was terribly wrong. Dr. X refused to order the test. We had a confrontation. We
would not leave until a MRI was ordered. They would have to drag us out.
Finally, the doctor relented. Alexander was wheeled into the MRI suite. We told
him that he would sleep for a while and then when he woke up mommy and daddy
would be there and we would go home. An hour later we had the news. It was
surrealistic like the first time we were told our precious son has a brain
tumor.
Dr. X shook his head and told us that Alexander had over 30 tumors
throughout his brain and spine.
"What does that mean?" we asked completely stunned.
"I’m afraid that it means that he has about three days to live,"
he told us.
We were ushered out of the MRI suite. Alexander was waking up slowly
recovering from the powerful drug Nebutal. He smiled because mommy and daddy
were standing over him.
"Mommy, I have to throw-up," he said apologetically and threw up on
the floor.
"It is ok Alexander, it is ok Ninouche, mommy loves you so much."
We were keeping back our tears to maintain our sanity in front of our 2 ½
year-old son. One of Alexander’s neurosurgeons stopped in to look at the MRI
and then came out to talk with us.
"What is it?" we asked him.
"Leptomeningeal sarcoma. I am so sorry. There is nothing we can
do."
"How is this possible?"
"It happens," he said.
"How often," we asked.
"It happens sometimes. I’m sorry, I’ve got to get back to the OR,"
he said and left.
Dr. X added, "Oh, yes I have seen this a lot," and walked back
inside the MRI suite.
We stood silently, holding Alexander’s hands.
"I’m going to ask Dr. X what we can do," I said to my wife.
Without asking permission, I returned to the MRI suite. Dr. X was laughing
with one of the nurses. When he saw me his demeanor changed and the nurse got
off the table where she was sitting and walked away.
"The only thing we can do is send you home with hospice care. I’ll give
you a prescription for morphine and decadron," Dr. X said as he awkwardly
patted me on the shoulder. "I think it is better to keep your son here
tonight and you can go home tomorrow," he added.
Alexander hung on for almost two more weeks. He wanted desperately to stay alive.
He loved life. He loved his mommy and daddy and he wanted very much to stay
with us and grow up and go fishing and do all the things we promised him that
we would all do together. Alexander died on January 31, 1999. He was only 2 ½
years old.
After Alexander was buried, Raphaele and I wanted to know what happened. No
one ever told us that the cancer could come back and kill Alexander while he
was on chemotherapy. In fact, Alexander was only one quarter the way into a
twelve-month chemo protocol. We used Medline the electronic medical index
available on the internet to search for "leptomeningeal sarcoma" the
cancer that had grown so rapidly and killed him. One of the abstracts that came
back stunned us. It was a study published in 1994 by a leading pediatric
oncologist of St. Judes. It discussed the "leptomeningeal
progression" of medulloblastoma in thirteen children Alexander’s age who
were given chemotherapy. It explained how the cancers returned and spread in
eleven of the thirteen children within five months. This abstract described in
detail exactly what happened to our son. In fact, the treatment went so poorly
that according to the abstract:
"Progressive disease
required early termination of chemotherapy in 11 (out of 13) cases."
-
Gajjar A, Mulhern RK, Heideman RL, Sanford RA, Douglass EC, Kovnar EH, Langston
JA, JJ Jenkins, Kun LE. Medulloblastoma in very young children: Outcome of
definite craniospinal irradiation following incomplete response to
chemotherapy. J Clin Oncol 1994 June; 12(6): 1212-1216
In other words, it worked so poorly that the oncologists actually stopped
the therapy. Unfortunately, the abstract did not name the chemo these children
were given back in 1994.
"These couldn’t be the same drugs Alexander got. Alexander got state-of-the-art
chemo," I said to Raphaele in disbelief.
We were suspicious so we drove to the medical library at UCLA medical center
to retrieve the full text of the article. What we found sickened us. The chemo
that they had given these children was identical to the chemo the oncologists
had administered to Alexander. The four drugs were exactly the same. The cancer
that returned, metastasized and took Alexander’s life did so in less than five
months from the time when he had his surgeries. Right on schedule. Just like
the other children. Alexander never had a chance. The chemotherapy they had
given him had proven its uselessness years before.
After reading this article we wondered what else the oncologists had not
told us. We began to read hundreds of abstracts and articles on pediatric brain
cancer written by oncologists for oncologists. In the pages of their medical
journals we were amazed to find that they admitted to each other that
chemotherapy is ineffective, extremely dangerous, toxic and carcinogenic in the
treatment of medulloblastoma and other aggressive pediatric brain cancers. If
any of this information had been made available to us, we would have hidden
Alexander so that the oncologists couldn’t force these useless poisons into our
son.
What you are about to read will shock you. It is a story of oncologists
lying to parents about the efficacy of their therapy and using coercive tactics
such as threats of court orders to take children and submit them to treatments
that they know are torturous and ineffective. The quotations that follow come
from abstracts and articles printed in their peer reviewed medical journals
that trace the use of these drugs in children starting almost a quarter of a
century ago. It is organized in chronological order. All the abstracts are
available on Medline (http://www.ncbi.nlm.nih.gov/PubMed/). Most medical
libraries can provide the full articles. To make it easier to follow the chemo
drugs they gave Alexander, they are bolded in the quotes and listed below.
Incredibly, all these drugs are still being administered today to children
whether or not the parents consent.
Alexander was put on protocol CCG 9921 that consists of:
1976
Vincristine causes seizures: In 1976, the oncologists
experiment on children with a drug called vincristine. Twenty-two years
later, they would administer the same drug to Alexander. Here in 1976 they find
that the drug causes seizures.
"Seventeen children
with clinical evidence of recurrent brain tumor were treated with vincristine
for 12 weeks…The toxicity encountered was minimal except for seizures…"
-
Rosenstock JG, Evans AE, Schut L:
Response to vincristine of recurrent brain tumors in children. J Neurosurg
1976 Aug; 45(2): 135-40.
1978
Vincristine does not eliminate cancer: A year later,
they tested vincristine with two other chemotherapy drugs on more
children. The tumors returned in an average of 45 weeks with the chemo.
"Seventeen patients
with recurrent medulloblastoma were treated with a combination of three drugs:
procarbazine, CCNU and vincristine. The median time to progression (the
time when the tumor returned) for all patients was 45 weeks."
- Crafts DC, Levin VA, Edwards MS, Pischer TL, Wilson
CB. Chemotherapy of recurrent medulloblastoma with combined procarbazine, CCNU,
and vincristine. J Neurosurg 1978 Oct; 49(4): 589-92.
1979
Response rate has nothing to do with survival: In 1979, an article
appeared that explained the significance of a response rate, the benchmark used
by all oncologists. A patient "responds to therapy" when their tumor
shrinks, but apparently this has nothing to do with survival. A tumor
"responds," that is shrinks a little, then quickly grows and spreads.
In this example, five children with medulloblastoma (the same tumor as
Alexander) "responded," but as of 1979, three had already died.
"Five children with
recurrent medulloblastoma were treated with Vincristine, BCNU,
Methotrexate and Dexamethasone. All five patients responded to therapy. Two of
the patients are alive…"
- Duffner
PK, Cohen ME, Thomas PR, Sinks LF, Freeman AI. Combination chemotherapy in
recurrent medulloblastoma. Cancer 1979
Jan; 43(1): 41-5.
1980
Oncologists experiment on children: As bizarre as it may seem to you
or I, experimenting on children is permissible behavior for pediatric
oncologists. They have been allowed free access to our children’s bodies with
no accountability. There are four reasons for this. First, children with cancer
are not allowed access to alternative cancer therapies. A steady stream of new
victims is assured because other treatment options are outlawed. Second, the
rate of pediatric brain cancers continues to rise. Third, if parents do not
willingly give their children to oncologists the child will be forcibly taken.
Fourth, after the child dies there are no repercussions. The oncologist’s
compensation, reputation, position, career prospects, and opportunities for
advancement have no relationship to whether or not his young patients live or
die. Alexander’s last three months were spent being injected with dozens of
drugs, vomiting, losing his hair, losing his eyesight, losing his ability to
walk, losing hearing in one ear, having radioactive substances injected into
his body, receiving blood transfusions, having GCSF injections shot into his
legs after each chemo session etc, etc. Then the cancer came back with a
vengeance and Alexander was given a death sentence by his oncologist who washed
his hands of us. "Sorry, I’ll arrange for hospice care." And that was
that. Don’t call us we will call you.
In the name of science, oncologists have carried out hideous experiments on
children with brain cancer. In the experiment below, a new chemo regimen is
tried out in five children. The drugs are so toxic that three die from the
toxicity, one dies from cancer, and the fifth is alive "but he is
demented."
"The first five
patients also received (chemotherapy) during radiotherapy. The toxicity in the
five patients was very severe. There were three toxic deaths, one death from
cancer; one patient survives disease free, but he is demented." - Thomas PR, Duffner PK, Cohen ME, Sinks LF, Tebbi C,
Freeman AI. Multimodality therapy for medulloblastoma. Cancer 1980 Feb
15; 45(4): 666-9.
1981
Chemotherapy does not affect survival: Two years later, vincristine
is part of another chemo experiment that is administered to more children with
brain cancer. The only thing that changes is the body count. The chemotherapy
is still useless.
"The data showed no improvement in the survival of such children
when adjuvant therapy (chemotherapy) was given."
- van Eys J, Chen T, Moore T, Cheek W,
Sexauer C, Starling K. Adjuvant chemotherapy for medulloblastoma and
ependymoma using iv vincristine, intrathecal methotrexate, and intrathecal
hydrocortisone: a Southwest Oncology Group Study. Cancer Treat Rep 1981
Jul-Aug; 65(7-8): 681-4.
Vincristine is toxic: That same year, another experiment
with children demonstrated that vincristine was toxic to the nervous
system, caused blindness, and could cause cardiorespiratory arrest.
"Three children with
malignancies developed severe neurotoxicity, including transient cortical
blindness, following chemotherapy regimens. The only drug in common was vincristine…one
child had a cardiorespirartory arrest…"
- Byrd RL, Rohrbaugh TM, Raney RB Jr, Norris DG.
Transient cortical blindness secondary to vincristine therapy in childhood
malignancies. Cancer 1981 Jan 1; 47(1): 37-40.
When I found that article I was particularly saddened. We both cried when we
remembered how, after getting vincristine, Alexander’s eyes would burn
and bother him. We would pat his eyelids with a cool damp cloth to help ease
the pain. It helped a little but his sight was terribly impaired and he would
collide into walls crashing his head with a "bang" you could hear
throughout the apartment. Raphaele and I asked his oncologist what was going on
and he assured us that the drugs had nothing to do with Alexander’s
deteriorating eyesight.
Chemotherapy does not affect survival: That same year, another
experiment demonstrates that vincristine and other chemo drugs do not
prolong survival.
"Survival with the
chemotherapy used in this study (procarbazine, vincristine, and
prednisone) was not superior to the survival of children who received
craniospinal irradiation only."
- Seiler RW, Bernasconi S, Berchtold W, Feldges A,
Imbach P, Luthi A, Pluss HJ, Vassella F, Wyss M, Wagner HP. Adjuvant
chemotherapy with procarbazine, vincristine and prednisone for
medulloblastomas. A preliminary report. Helv Paediatr Acta 1981 Jul;
36(3): 249-54.
Chemotherapy does not stop the cancer from spreading: It’s 1981 and
oncologists admit that they are on the wrong track. They state that chemo
doesn’t stop brain cancer from spreading throughout the brain and spine.
"Cerebrospinal fluid
dissemination of medulloblastoma occurs despite adequate systemic
chemotherapy…"
-
Edwards MS, Levin VA, Seager ML,
Wilson CB. Intrathecal chemotherapy for leptomeningeal dissemination of
medulloblastoma. Childs Brain 1981; 8(6): 444-51.
1982
Vincristine destroys eyesight: The fact that
oncologists were already warned that vincristine was dangerous to a
child’s eyesight didn’t seem to make an impression. It didn’t for Alexander’s
oncologist in 1998. This article is written about another child who nearly goes
blind from vincristine in 1982.
"Bilateral optic
atrophy developed in a 15 year old patient receiving radiation therapy and weekly
vincristine for medulloblastoma…Visual loss occurring in a patient
receiving vincristine should alert the physician to the possibility that
the process is drug related."
-
Shurin SB, Rekate HL, Annable W. Optic
atrophy induced by vincritstine. Pediatrics 1982 Aug; 70(2): 288-91.
Vincristine can kill: In the next article, the
oncologists discuss what happened when they administered vincristine by
accident. They undertook "detailed clinical observations" for
seventeen days, the amount of time it took for the child to die.
"A case is described of
accidental intrathecal administration of vincristine, with detailed
clinical observations over a 17 day period. The toxicity…resulted in death. The
onset was characterized by opisthotonos, followed by ascending paralysis and
finally bulbar and cerebral involvement." - Manelis J, Freudlich E,
Ezekiel E, Doron J. Accidental intrathecal vincristine administration. Report
of a case. J Neurol 1982; 228(3): 209-13.
1983
Cisplatin destroys hearing and leads to neurologic
deterioration: In 1983, the danger of another chemo drug, cisplatin,
is discovered, but only after trying it out on children. This is another drug
the oncologists would inject into Alexander fifteen years later.
"Six children received cisplatin
for recurrent brain tumor. Five of the six children had evidence of significant
hearing loss after only one cycle of treatment. Two (children)…developed
profound deterioration in neurologic status within 72 hours after infusion."
- Granowetter L, Rosenstock JG, Packer RJ: Enhanced cis-platinum
neurotoxity in pediatric patients with brain tumors. J Neurooncol 1983;
1(4):293-7.
Cyclophosphamide does not affect survival: That same
year, another chemotherapy drug called cyclophosphamide is tried out on
children. It does not effect survival. This is the third of four drugs they
would administer to Alexander many years later. This article admits that even
if a drug is "active" and temporarily shrinks a tumor, it does not
prolong life. This admission echoes the one from 1979 in which a response rate
has nothing to do with survival. The oncologists are admitting that an
"active" chemo drug that creates a "response" (temporarily
shrinks the tumor) has no "important effect on survival."
Fourteen children with brain
tumors were given cyclophosphamide. "…Although cyclophosphamide
alone was an active agent in this context, these treatment regimens did not
have an important effect on survival."
- Allen JC, Helson L, Jereb B. Preradiation chemotherapy
for newly diagnosed childhood brain tumors. A modified Phase II trial. Cancer
1983 Dec 1; 52(11): 2001-6.
Therapy causes retardation: In this next experiment, chemo together
with radiation were shown to be sufficiently toxic to cause retardation.
"Ten children with
posterior fossa tumors (i.e. medulloblastoma) treated with radiation and
chemotherapy received intellectual evaluations…of the ten children evaluated,
all had either dementia, learning disabilities or evidence of intellectual retardation."
- Duffner PK, Cohen ME, Thomas P. Late effects of
treatment on the intelligence of children with posterior fossa tumors. Cancer
1983 Jan 15; 51(2): 233-7.
Vincristine kills again: Here is another example of accidentally
giving a child too much vincristine. In this case, the oncologists
watched this boy die over the course of 36 days. The autopsy found that his
brain had become necrotic (dead).
"A case of fatal
myeloencephalopathy (inflammation of the spinal chord and brain) secondary to
accidental intrathecal administration of vincristine is reported in a 16
year old boy. He underwent a progressive ascending chemical meningoencephalitis
leading to coma, and died 36 days after the injection. At autopsy, all regions
of the brain that had been in direct contact with the cerebrospinal fluid were
necrotic (dead)."
-Williams ME, Walker AN, Bracikowski JP, Garner L, Wilson KD, Carpenter
JT. Ascending myeloencephalopathy due to intrathecal vincristine sulfate. A
fatal chemotherapeutic error. Cancer 1983 Jun 1; 51(11): 2041-7.
Oncologists experiment on children’s ovaries & testes using
chemotherapy: As we have already seen, the oncologists have been allowed to
experiment on children without fear of ever being held accountable. In this
"study" the oncologists wondered what happened to children’s gonads
(ovaries and testes) after they were administered chemotherapy. After the
children were already given the drugs, the oncologists examined them. Not
surprisingly, the children who had been administered chemotherapy had
"evidence of gonadal damage."
"Gonadal function was
studied in two groups of children previously treated for medulloblastoma…In
group one, but not in group two, the children also received adjuvant
chemotherapy (BCNU or CCNU plus vincristine in four and procarbazine in
three patients). The nine children in group one showed clinical and biochemical
evidence of gonadal damage… In group two, each child…(developed) normally…We
conclude that nitrosoureas (chemotherapy) was responsible for the gonadal
damage…"
-
Ahmed SR, Shalet SM, Campbell RH,
Deakin DP. Primary gonadal damage following treatment of brain tumors in
childhood. J Pediatr 1983 Oct; 103(4): 562-5.
1984
Oncologists do not count the children who die while getting chemo:
The next year, several chemo drugs including vincristine, and etoposide,
are administered to children in another chemo experiment. Etoposide is
the fourth and last drug in the chemo cocktail they would administer to
Alexander fourteen years later. Predictably, in this experiment survival isn’t
appreciably affected. But this article is important for another reason. Most
chemo experiments mention that they started with a certain number of children
but only a much smaller number of children were "evaluable." We
always wondered what "evaluable" meant and what happened to those
missing children. Now, the question is answered. According to the article there
were four children who "were not evaluable due to early death." So
the children who are not evaluable are the ones who died while being treated.
These "non-evaluable" children are excluded from their final
statistics. The oncologists’ reasoning is a wonder to behold. They believe that
if a child has not had the "benefit" of the entire chemo regimen
(i.e. 12 months worth) then the regimen should not be penalized by counting
children who didn’t make it all the way through. Such bookkeeping provides a
convenient method to inflate the response rate (the number of children who had
their tumors temporarily shrink). For example, if 5 children responded out of
20 the response rate is 25%. But if only 10 of the 20 children are evaluable
(because the other 10 died before the therapy was completed) then the response
rate has suddenly increased to 50% (5 responders out of 10 evaluable patients
equals 50%). We have found this type of clever bookkeeping used in hundreds of
cancer experiments involving both children and adults.
"Twenty-two consecutive
patients with recurrent malignant brain tumors after radiation therapy and
systemic combination chemotherapy with BCNU and vincristine, four of
whom were not evaluable due to early death, were treated with etoposide.
Response was observed in three of 18 (17%) evaluable patients…Overall median
survival from the start of etoposide was 4.5 months."
- Tirelli U, D’Incalci M, Canetta R, Tumolo S, Franchin G, Veronesi A,
Galligioni E, Trovo MG, Rossi C, Grigoletto E. Etoposide (VP-16-213) in
malignant brain tumors: a phase II study. J Clin Oncol 1984 May; 2(5):
432-7.
1985
Oncologists admit that chemo is ineffective: A year later, after
trying out all the various chemo drugs on children, a group of pediatric
oncologists admit that the role of chemotherapy is "unclear, " that
"responses are generally transient," and "virtually no cures are
reported." They also admit again that an "active" drug (a drug
that may temporarily shrink a tumor) has no relationship to a cure.
Medulloblastoma is the most
common primary tumor of the central nervous system in childhood…The role of
adjuvant chemotherapy is unclear…Agents that have demonstrated activity include
vincristine, cyclophosphamide, cisplatin,
methotrexate…However, responses are generally transient and virtually no cures
are reported."
- Friedman HS, Schold SC Jr. Rational approaches to the
chemotherapy of medulloblastoma. Neurol Clin 1985 Nov; 3(4): 843-53.
Oncologists admit that chemo and radiation are toxic and ineffective:
Another group of oncologists go on record with the admission that conventional
therapy (chemotherapy and radiation) produces "poor results,"
"severe neurotoxicity" and is "not only toxic but
inadequate."
"(Conventional)
treatment has been least effective in very young children with brain
tumors…Since standard treatment has produced both poor results and severe
neurotoxicity…Current therapy of malignant brain tumors of infancy (children
under 36 months) in not only toxic, but inadequate."
- Duffner PK, Cohen ME. Treatment of brain tumors in
babies and very young children. Pediatr neurosci 1985-86; 12(6): 304-10.
1987
Oncologists admit that chemo is ineffective and increases the risk of
infection: In this experiment, the only thing chemo did was to increase the
risk of infection.
"The (survival) rate
was not improved by the chemotherapy program. An increased risk of infection
was associated with the chemotherapy."
- Jenkin RD,
Boesel C, Ertel I, Evans A, Hittle R, Ortega J, Sposto R, Wara W, Wilson C,
Anderson J, et al. Brain-stem tumors in childhood: a prospective randomized
trial of irradiation with and without adjuvant CCNU, VCR, and prednisone. A
report of the Children’s Cancer Study Group. J Neurosurg 1987 Feb;
66(2): 227-33.
Oncologists admit that chemo causes cancer: In this article several
pediatric oncologists admit that the conventional treatment for cancer (chemo
and radiation) will actually cause cancer.
"There is increasing
evidence that children with cancer…are at increased risk for development of
secondary central nervous system tumors; possibly due, in part, to previous
treatment."
- Packer
RJ, Meadows AT, Rorke LB, Goldwein JL, D’Angio G. Long-term sequelae of cancer
treatment on the central nervous system in childhood. Med Pediatr Oncol
1987; 15(5): 241-53.
Example of chemo causing cancer: Another medical article demonstrates
this fact. Here a boy with medulloblastoma gets a glioblastoma multiforme as a
result of his treatment (chemo and radiation). Although the abstract fails to
mention it, glioblastoma is the most dangerous brain tumor known and is rapidly
and universally fatal.
"The patient was
operated on for a cerebellar medulloblastoma at the age of 13 years.
Postoperative treatment included irradiation and chemotherapy. Six years later,
a glioblastoma multiforme was found at the original site of the
medulloblastoma…(earlier) treatment is considered the likely cause for the
later tumor development."
- Schmidbauer M, Budka H, Bruckner R, Vorkapic P.
Glioblastoma developing at the site of a cerebellar medulloblastoma treated 6
years earlier. Case report. J Neurosurg 1987 Dec; 67(6): 915-8.
The fact that chemotherapy actually causes cancer should be no surprise to
the oncologists. The chemotherapy they gave Alexander and thousands of other
children is listed as "Known Human Carcinogens" by the National
Institute of Health, the National Cancer Institute and the FDA. In fact, cyclophosphamide
was listed as a "Known Human Carcinogen" by the First Annual Report
on Carcinogens published by the U.S. Department of Health and Human Services
back in 1980. In addition, there are four other chemotherapy compounds on that
list. (Anyone with internet access can read the report for themselves at
http://ntp-server.niehs.nih.gov/htdocs/8_RoC/Known_list.html.) Furthermore, the
World Health Organization’s (WHO), International Agency for Research on Cancer
lists ten chemotherapy agents including cyclophosphamide and all
alkylating agents as "Materials known to be carcinogenic to humans."
(This document can be seen at
http://www.science.tamu.edu/safety/carcinogens.html.) It is hard to believe
that oncologists would be injecting known human carcinogens into children with
cancer. But, that is exactly what they are doing. They should not feign
surprise when the children begin developing secondary cancers. This is what
happened to Alexander. His first cancer was medulloblastoma. After three months
of chemotherapy the cancer returned as 30 separate tumors. At that point the
doctors called it "leptomeningeal sarcoma." It was a different cancer
now.
Let’s summarize. It’s 1987 and chemotherapy has been used to treat children
with aggressive brain tumors for at least eleven years. In that amount of time
there have been "virtually no cures," a tremendous record of toxicity
including secondary cancers, and admissions by numerous oncologists that they
are on the wrong track. Let us jump ahead a few years to 1990 to see what
happens next.
1990
Chemo is still in use in pediatric brain tumors: It is 1990 and the
oncologists are still experimenting on children using exactly the same
chemotherapy. Here they are busily administering chemo to roughly half of 286
children. The experiment proves once again that chemo provides no benefit.
"Two hundred and
eighty-six patients with medulloblastoma from 46 centers in 15 countries were
treated…All patients were treated by craniospinal irradiation. (Approximately
half) were randomly allocated to receive adjuvant chemotherapy…late relapses
have occurred…and the difference between the two groups (those who received
chemo and those who did not) has been lost." - Tait DM,
Thornton-Jones H, Bloom HJ, Lemerle J, Morris-Jones P. Adjuvant chemotherapy
for medulloblastoma: the first multi-centre control trial of the International
Society of Paediatric Oncology (SIOP I). Eur J Cancer 1990 Apr; 26(4):
464-9.
Does chemo benefit anyone? One oncologist admits that he doesn’t know
which children will benefit from chemotherapy.
"It remains to be
determined which…patients are most likely to benefit from chemotherapy."
- Packer RJ. Chemotherapy for medulloblastoma/primitive
neuroectodermal tumors of the posterior fossa. Ann Neurol 1990 Dec;
28(6): 823-8.
Chemo and radiation do not cure: Oncologists go on record stating
that a "cure" for medulloblastoma is currently "unknown."
"It remains unknown,
however, whether the patient with a medulloblastoma is ever cured."
-
Sutton LN, Packer RJ, Schut L. Medulloblastomas. Neurosurg Clin N Am
1990 Jan; 1(1): 97-109.
Chemo is toxic and ineffective: Other oncologists admit that
chemotherapy provides a "poor quality of life" and
"minimal" benefit.
"The prognosis of
childhood brain tumors is severe because of a high tumor-related mortality and
a poor quality of life…Till now, the benefit due to chemotherapy in the
treatment of these tumors has been minimal…"
-
Kalifa C, Jouvet P. [Current indications of chemotherapy in the treatment of
malignant brain tumors in children]. [Article in French] Bull Cancer
1990; 77(12): 1169-74.
1991
Chemo leads to destruction of hearing, infertility and secondary cancers:
You may recall that oncologists knew in 1983 that the chemo drug cisplatin
destroyed a child’s hearing. But eight years later they "discover"
this again. You may also recall that they knew chemo caused cancers in children
in 1987 but four years later they are still using it with the same results.
Complications of
chemotherapy include,"permanent hearing impairment secondary to cisplatin,
infertility and an increased risk of second primary neoplasms."
- Allen JC: Complications of chemotherapy in patients
with brain and spinal cord tumors. Pediatr Neurosurg 1991-92; 17(4):
218-24.
Response rate has nothing to do with survival: Similar to the article
written in 1979, the article below reveals that a "response" to
chemotherapy has little to do with survival. Here all six children
"responded" and all six children died.
"Various chemotherapeutic
agents are transiently effective in recurrent PNET/Medulloblastoma, but
long-lasting responses are rarely attainable. Seven patients - ages 2-18 years
- (were treated with) lomustine, cisplatin and vincristine. Six
of six evaluable patients responded to chemotherapy… All six patients have
subsequently died…"
- Lefkowitz
IB, Packer RJ, Siegel KR, Sutton LN, Schut L, Evans AE. Results of treatment of
children with recurrent medulloblastoma/primitive neuroectodermal tumors with
lomustine, cisplatin, and vincristine. Cancer 1990 Feb 1; 65(3): 412-7.
Chemo causes cancer: Chemotherapy has been known to cause cancer for
many years but it is still being administered. Not surprisingly, more children
are getting secondary cancers as a "treatment related complication."
"Leukemia of mixed
lineage, was diagnosed in a 6.5 year old boy with a history of
medulloblastoma...Therapy has included radiation and chemotherapy…leukemia is a
treatment related complication for patients with past brain tumors…"
-
Blatt J, Penchansky L, Phebus C, Horn
M. Leukemia in a child with a history of medulloblastoma. Pediatr Hematol
Oncol 1991 Jan-Mar; 8(1): 77-82.
1992
Oncologists wonder why cyclophosphamide doesn’t work: Now it
is 1992 but nothing has changed. After admitting that chemotherapy is toxic and
ineffective, these same oncologists are still injecting the same drugs into new
victims. In this article, the oncologists wonder why cyclophosphamide
does not work. Their conclusion? Medulloblastoma is resistant to cyclophosphamide.
"Mechanisms to cyclophosphamide
(4-HC) were studied…Multiple distinct mechanisms of resistance were
demonstrated."
-
Friedman HS, Colvin OM, Kaufmann SH,
Ludeman SM, Bullock N, Bigner DD, Griffith OW. Cyclophosphamide resistance in
medulloblastoma. Cancer Res 1992 Oct 1; 52(19): 5373-8.
You may recall that in the past, cyclophosphamide was already shown
not to affect survival. But for some reason the oncologists kept prescribing it
and countless children have been given the drug anyway. You may recall this
statement from 1983:
"…Although cyclophosphamide
alone was an active agent in this context, these treatment regimens did not
have an important effect on survival."
- Allen JC, Helson L, Jereb B. Preradiation chemotherapy
for newly diagnosed childhood brain tumors. A modified Phase II trial. Cancer
1983 Dec 1; 52(11): 2001-6.
As we have seen, the oncologists have admitted that chemo is toxic, provides
poor quality of life and does not prolong survival for children with brain
tumors. Yet, they continue to use various means to force and coerce parents to
allow them to inject these poisons into the veins of innocent children.
1993
The chemo is not the problem, it’s the children who are at fault:
It’s 1993 and the oncologists have a new strategy. The drugs are exactly the
same. What is different is who is to blame when the therapy fails. Now, the
problem isn’t that the chemotherapy is worthless. The problem is the children.
They just have a poor prognosis.
"Children younger than
5 years who have PNET have a poor prognosis."
- Goldwein JW, Radcliffe J, Packer RJ, Sutton LN, Lange
B, Rorke LB, D’Angio GJ. Results of a pilot study of low-dose craniospinal
radiation therapy plus chemotherapy for children younger than 5 years with
primitive neuroectodermal tumors. Cancer 1993 Apr 15; 71(8): 2647-52.
Other oncologists agree:
Among patients with
malignant brain tumors, infants and very young children have the worst
prognosis and the most severe treatment-related neurotoxic effects."
- Duffner PK, Horowitz ME, Krischer JP, Friedman HS,
Burger PC, Cohen ME, Sanford RA, Mulhern RK, James HE, Freeman CR, et al.
Postoperative chemotherapy and delayed radiation in children less than three
years of age with malignant brain tumors. N Engl J Med 1993 Jun 17;
328(24): 1725-31.
Chemo is the problem: But some oncologists are uncomfortable with
this new "blame it on the victim" mentality and are still willing to
admit that the problem isn’t the children, it’s the chemotherapy.
"…the absolute benefit
of chemotherapy for the treatment of medulloblastoma in childhood is, as yet,
not proven."
- Attard-Montalto S, Plowman N, Breatnach F, Saha V,
Eden OB. Is there a danger in delaying radiotherapy in childhood
medulloblastoma? Br J Radiol 1993 Sep; 66(789): 807-13.
Chemo and radiation can kill: But chemotherapy isn’t only
ineffective. It’s also dangerous. This little girl was killed by the
combination of radiation and chemo that the oncologists gave her. The treatment
caused her brain to become "necrotic" or dead.
A three year old girl
received (radiation and chemotherapy for a recurrence)…After two months of
chemotherapy, central nervous system toxicity progressed rapidly from ataxia to
paraplegia to quadriplegia to central respiratory failure. Radiographic scans
and autopsy material revealed brain stem necrosis."
- Watterson J, Simonton SC, Rorke LB, Packer RJ, Kim TH,
Spiegel RH, Priest JR. Fatal brain stem necrosis after standard posterior fossa
raidation and aggressive chemotherapy for metastic medulloblastoma. Cancer
1993 Jun 15; 71(12): 4111-7.
1994
It is 1994 and after almost 20 years of admitting that chemo does not work
in pediatric brain tumors the oncologists are still administering the same
drugs. Predictably the children react in the same way - they relapse and die.
More chemo failure: Here they gave children a chemo cocktail
containing three of the four drugs they would later give Alexander. Tumors
returned in six months.
Children (with PNET’s and
ependymomas) were treated with a CCG (chemotherapy) protocol…The median time to
progression (return of the tumor) was 6 months."
-
Geyer JR, Zeltzer PM, Boyett JM,
Rorke LB, Stanley P, Albright AL, Wisoff JH, Milstein JM, Allen JC, Finlay JL,
et al. Survival of infants with primitive neuroectodermal tumors or malignant
ependymomas of the CNS treated with eight drugs in 1 day: a report from the
Childrens Cancer Group. J Clin Oncol 1994 Aug; 12(8): 1607-15.
Tumors return in seven months: In this chemo experiment they gave
children the exact same four drugs they would give Alexander four years later.
For most of the children, the tumors returned in seven months.
"…Responses were short
lived, with two patients relapsing while still receiving chemotherapy. Three of
four very young children relapsed within 7 months of completing
chemotherapy…"
- Gaze MN, Smith DB, Rampling RP, Simpson E, Barrett A.
Combination chemotherapy for primitive neuroectodermal and other malignant
brain tumours. Clin Oncol (R Coll Radiol) 1994; 6(2): 110-5
The exact same drugs they would give Alexander in 1998 are again proven
ineffective: Then there is the study that started our research. In this
experiment at St. Judes Children Research Hospital, cyclophosphamide,
vincristine, etoposide and cisplatin were administered to thirteen
children. These children were the exact same age and had the exact same tumor
as Alexander. In this study these chemo drugs worked so poorly that the cancers
returned in an average of five months. As a result, the experiment
"required early termination." The majority of the children had
"leptomeningeal progression" - the cancers spread throughout their
brains and spines. But this would not stop oncologists from continuing to use
these exact same useless drugs on Alexander and other children for years to
come. In fact, these drugs are being forcibly used on children even now as you
read this.
"Thirteen young
patients (under 36 months) with medulloblastoma were treated with
preirradiation multiagent chemotherapy…Two patients completed the scheduled
chemotherapy with residual disease and received delayed radiation therapy. The
remaining eleven patients had either local or leptomeningeal progression during
chemotherapy (median time to progression, 5 months)…Progressive disease
required early termination of chemotherapy in (these) eleven cases …"
-
Gajjar A, Mulhern RK, Heideman RL,
Sanford RA, Douglass EC, Kovnar EH, Langston JA, JJ Jenkins, Kun LE.
Medulloblastoma in very young children: Outcome of definite craniospinal
irradiation following incomplete response to chemotherapy. J Clin Oncol 1994
June; 12(6): 1212-1216
Note that in these last three experiments the children’s cancers returned in
an average of 6, 7 and 5 months after the original tumor was surgically removed.
Raphaele and I wondered how this figure of 5-7 months compared to the time to
recurrence in the era before chemotherapy and radiation. In other words, when
surgery was used by itself, did the tumors return faster, slower or at the same
rate? The answer to this question would indicate if chemo does anything to slow
the return of the cancer.
To get the answer we read the books and articles written by Drs. Harvey
Cushing and Percival Bailey. These were the first neurosurgeons in the United
States who actually named medulloblastoma almost eighty years ago. During the
first quarter of the twentieth century these early neurosurgeons removed
medulloblastomas and other brain tumors at the Surgical Clinic of the Peter
Bent Brigham Hospital in Boston. It took longer to diagnose in those days
because they didn’t have MRI or CT machines, but according to their data,
children lived an average of eleven months from when they were first diagnosed.
These were children whose only therapy was surgery - there was no chemotherapy
or radiation used. (Some patients were treated post-surgically with radium or
roentgen-rays but these children were not counted to arrive at the eleven month
average.) Furthermore, most of these patients did not have their tumors
completely removed because of the lack of sophisticated surgical technology.
Later, when the tumor recurred, Cushing and Bailey would simply operate to
remove it a second or even third time. Cushing and Bailey wrote:
In one case, the patient had
an extraordinarily long survival period, twenty-one months, from the time of
the first operation, which amounted merely to a decompression. At two
subsequent operations, the tumor, which the decompression had permitted to attain
an enormous size, was radically extirpated…It will be seen also that the next
three patients operated on (cases 11, 12 and 13) had survival periods of nine,
ten and sixteen months, respectively…"
-
Bailey P, Cushing H. Medulloblastoma Cerebelli: A Common type of Midcerebellar
Glioma of Childhood. Archives of Neurology and Psychiatry. Volume 14,
1925; 192-224
Today, children on chemotherapy, have their brain cancers return in an
average of 5-7 months. With chemo, Alexander lived a little more than five months
from when he was diagnosed and he had all his tumor removed. This meant that in
the days when brain surgery was just invented and chemotherapy didn’t yet
exist, many children with medulloblastoma lived longer than they do today. But
today, we have superior surgical technique and the extent of tumor removal is
greater. Incredibly, the children operated on 70 and 80 years ago already beat
Alexander in terms of survival, but if these kids had had the benefit of a
modern surgery they might have lived even longer. Who knows how long these
children would have lived if they had been given a modern operation.
This meant that chemotherapy was shortening children’s lives, not
lengthening them!
Without chemo, Alexander wouldn’t have had been poisoned. He wouldn’t have
had to spend his last months on earth in a hospital. He could have visited
Disneyland and SeaWorld and played on the beach that he loved so much. Without
chemo, Alexander wouldn’t have been isolated from his friends and family. He
could have had the most joy you could pack into a child’s life. And most of
all, without chemo, Alexander probably would have lived longer and would have
undoubtedly enjoyed a superior "quality of life."
Response rate is entirely subjective: This next article raised the curtain
on the "science" behind these chemo experiments. As we have learned,
when a study says that a child responded this means that the tumor shrunk
temporarily. This is considered a success for the oncologist. Even when the
children die, the oncologists focus on the response rate. The tumor responded,
returns with a vengeance and kills the child. Yes, but, there was a response! A
point in favor of chemo. If oncologists focused on duration and quality of life
there would be no role for chemotherapy whatsoever. But in next article we see
that response rates themselves are doubtful. This quote is taken from an
article published by Memorial Sloan-Kettering Cancer Institute. In it an
"institutional review" documents a 33% response rate. However, when
the exact same patients are seen by the "central review" the response
rate drops to 18%. We now understand that a "response rate" lies in
the eyes of the beholder. This suggests that an oncologist can find a response
rate where none exists:
"One hundred and thirty
children less than 21 years of age with newly-diagnosed high-grade astrocytoma
were treated with ‘eight-drugs-in-one-day’ chemotherapy…Of 79 patients with
evaluable post-operative residual tumor on CT or MRI scans 26 (33%) were
determined on institutional evaluation to have had an objective response.
However, central review of scans documented responses on only 14 (18%)…The
differences in response rates reported by institutional and central review
highlight the difficulties inherent in assessing response to brain tumor
therapy."
-
Finlay JL, Geyer JR, Turski PA, Yates AJ, Boyett JM, Allen JC, Packer RJ.
Pre-irradiation chemotherapy in children with high-grade astrocytoma: tumor
response to two cycles of the "8-drugs-in-1-day" regimen. A Childrens
Cancer Group study, CCG-945. J Neurooncol 1994; 21(3):255-65.
1995
Here we are in 1995 and more children are given the same toxic and worthless
drugs with the same results.
"Chemotherapy consisted
of vincristine, procarbazine and methotrexate…No benefit for the receipt
of pre-radiation chemotherapy could be demonstrated..."
-
Bailey CC, Gnekow A, Wellek S, Jones
M, Round C, Brown J, Phillips A, Neidhards MK. Prospective randomised trail of
chemotherapy given before radiotherapy in childhood medulloblastoma. International
Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric
Oncology (GPO): SIOP II. Med Pediatr Oncol 1995 Sep; 25(3): 166-78.
Same drugs, more deaths: In the article quoted below, the oncologists
admit that all the children died and that chemotherapy "was neither
effective in controlling the tumor at the primary (original) site" nor in
preventing it from spreading.
"Chemotherapy consisted
of two 28-day cycles of cyclophosphamide plus vincristine,
followed by one 28-day cycle of cisplatin plus etoposide…All
children ultimately failed chemotherapy (2 months-11 months)…All children
died…This chemotherapy regimen was neither effective in controlling the tumor
in the primary site nor in treating or preventing leptomeningeal spread."
- Duffner PK, Cohen ME, Sanford RA, Horowitz ME,
Krischer JP, Burger PC, Friedman HS, Kun LE: Lack of efficacy of postoperative
chemotherapy and delayed radiation in very young children with pineoblastoma.
Pediatric Oncology Group. Med Pediatr Oncol 1995 Jul;25(1):38-44.
The children die because the therapy is ineffective: Oncologists
deduce that the children’s deaths are due to the cancer’s resistance to
chemotherapy, specifically a chemo drug called cyclophosphamide.
Many clinical trials
"noted that many children with newly diagnosed or recurrent
medulloblastoma frequently displayed initial or subsequent resistance to cyclophosphamide…Development
of drug resistance was invariably the harbinger of…death of the patient."
-
Friedman HS, Bigner SH, Bigner DD. Cyclophosphamide therapy of medulloblastoma:
from the laboratory to the clinic and back again (and again and again). J
Neurooncol 1995; 24(1): 103-8.
If you review the papers quoted above (1983 and 1992), you will note that
oncologists had already admitted that cyclophosphamide does not work in
medulloblastoma. This pattern of using a chemo drug, admitting it is
ineffective, and then continuing to use it on children is incomprehensible.
1996
Chemo is toxic and ineffective: Predictably, the next year it is still
the same drugs and the same horrific results.
"Twenty eight children
with a variety of malignant brain tumors have received the regimen, which
contains carboplatin, vincristine, cyclophosphamide,
methotrexate, and cisplatin. The treatment is toxic…all but three
children eventually required radiation…"
- Lashford LS, Campbell RH, Gattamaneni HR, Robinson K,
Walker D, Bailey C. An intensive multiagent chemotherapy regimen for brain
tumours occurring in very young children. Arch Dis Child 1996 Mar; 74(3):
219-23.
Cisplatin still destroys hearing: Remember Cisplatin and
hearing loss?
"Cisplatin
induced hearing loss…may progress insidiously and rapidly."
- Ilveskoski I, Saarinen UM, Wiklund T, Perkkio M, Salmi
TT, Lanning M, Makipernaa A, Pihko H. Ototoxicity in children with malignant
brain tumors treated with the "8 in 1" chemotherapy protocol. Med
Pediatr Oncol 1996 Jul; 27(1): 26-31.
That was written in 1996, do you recall this from 1983?
"Six children received cisplatin
for recurrent brain tumor. "Five of the six children had evidence of
significant hearing loss after only one cycle of treatment."
- Granowetter L, Rosenstock JG, Packer RJ: Enhanced
cis-platinum neurotoxity in pediatric patients with brain tumors. J
Neurooncol 1983; 1(4):293-7.
The inexplicable use of dangerous drugs that oncologists admit are
ineffective continues. For these oncologists, it seems nothing has changed in
thirteen years except more children getting injured by drugs that are supposed
to help them. Each child represents income to the oncologist and profits to the
drug company that sells the chemotherapy. Of course, none of these victims are
the oncologist’s children.
The outcome with conventional therapy "remains poor":
Oncologists are not shy about admitting to each other that what they are doing
does not work.
"The outcome for the
majority of children with malignant brain tumors remains poor, despite surgery,
irradiation and conventional chemotherapy."
- Finlay JL. The role of high-dose chemotherapy and stem
cell rescue in the treatment of malignant brain tumors. Bone Marrow
Transplant 1996 Dec; 18 Suppl 3:S1-5
Chemo remains "unproven": Oncologists continue to question
the value of chemo but they keep right on prescribing it.
"…the value of
preradiation chemotherapy remains unproven."
-
Packer RJ. Brain tumors in children.
Curr Opin Pediatr 1996 Dec; 8(6): 549-57.
1997
Chemo does not work: The same toxic and ineffective drugs. The same
results. More tortured and dead children. More grieving parents.
"We treated 25 children
with nondisseminated medulloblastoma…with carboplatin and vincristine…Our
experience with this adjuvant chemotherapy regimen with carboplatin and vincristine,
as used by us, does not encourage its adoption in future clinical trials."
- Bergman I, Jakacki RI, Heller G, Finlay J. Treatment
of standard risk medulloblastoma with craniospinal irradiation, carboplatin,
and vincristine. Med Pediatr Oncol 1997 Dec; 29(6): 563-567.
Vincristine causes neurotoxicity: The oncologists seem
surprised that vincristine causes brain death:
"We describe a very
unusual case of fulminant (sudden and severe) neuropathy in a child who was
previously exposed to vincristine. The clinical picture resembled brain
death…"
- Bakshi N, Maselli RA, Gospe SM Jr, Ellis WG, McDonald
C, Mandler RN. Fulminant demyelinating neuropathy mimicking cerebral death. Muscle
Nerve 1997 Dec; 20(12): 1595-7.
That was written in 1997. Do you recall these comments written in 1981,
sixteen years earlier?
"Three children with
malignancies developed severe neurotoxicity, including transient cortical
blindness, following chemotherapy regimens. The only drug in common was vincristine…one
child had a cardiorespirartory arrest…"
- Byrd RL, Rohrbaugh TM, Raney RB Jr, Norris DG.
Transient cortical blindness secondary to vincristine therapy in childhood
malignancies. Cancer 1981 Jan 1; 47(1): 37-40.
Chemo in children is a big experiment: Here in 1997 is an outrageous
admission. The oncologists confess that although they have been using these
chemo drugs to treat brain tumors for over twenty years they have no
idea how much of the drug is delivered to the brain.
"Although both cyclophosphamide
and ifosfamide are used in the treatment of central nervous system tumors,
little is known about the concentration of either drug or their metabolites in
the cerebrospinal fluid of children."
-
Yule SM, Price L, Pearson AD, Boddy
AV. Cyclophosphamide and ifosfamide metabolites in the cerebrospinal fluid of
children. Clin Cancer Res 1997 Nov; 3(11): 1985-92.
Chemo still causes cancer: In this article published by the National
Cancer Institute, the oncologists admit that a child has a 5.4-fold excess
chance of getting cancer after being treated with conventional therapy.
Using conventional therapy,
"overall, there was a 5.4-fold excess of second neoplasms
(cancers)…Significantly elevated risks were seen for cancers of the salivary
glands, cervix uteri, brain and CNS, thyroid gland, and acute lymphoblastic
leukemia."
- Goldstein AM, Yuen J, Tucker MA. Second cancers after
medulloblastoma: population-based results from the United States and Sweden. Cancer
Causes Control 1997 Nov; 8(6):865-71.
With orthodox treatment, medulloblastoma is fatal: Here’s a statement
from oncologists at Harvard Medical School that with only rare exceptions,
recurrent medulloblastoma is "universally fatal."
"Recurrent
medulloblastoma has long been considered universally fatal. In spite of
attempts to improve its treatment, only rarely have long term survivors been
documented in the world’s medical literature."
-
Balter-Seri J, Mor C, Shuper A,
Zaizov R, Cohen IJ. Cure of recurrent medulloblastoma: the contribution of
surgical resection at relapse. Cancer 1997 Mar 15; 79(6): 124-7.
Chemo is still ineffective: In this next chemo experiment from St.
Jude Childrens Hospital, seventeen of twenty-three children with
medulloblastoma had their cancers spread while getting chemo. This particular
oncologist had used the same drugs three years before with such poor results
that he pulled the plug on that experiment. But here he is using the same drugs
again on a new group of children.
"Chemotherapy regimen
depended on protocol, but usually included cisplatin or carboplatin
and etoposide, +/- cyclophosphamide and vincristine…(There
were 23 patients under 3 years old) seventeen patients progressed
(had the tumor return) during chemotherapy…"
- Richard
Heideman M.D., et al; Patterns of failure in children with medulloblastoma:
effects of preirradiation chemotherapy in The International Journal of
Radiation Oncology, Biology and Physics; August 1, 1997, volume 39(1),
pages 15-24.
1998
But even after these admissions that "virtually no cures are
reported" with chemo in 1985, that chemo is "controversial" in
1991, "unproven" in 1993, and provides "a poor rate of survival
and high treatment associated morbidity (i.e. side effects)" in 1997,
nothing changes. Here we are in 1998. The children are still getting the same
drugs. The children die of the disease or the chemo itself. The conclusion is
that the treatment doesn’t work. How many dead children did it take to reach
that conclusion? What’s worse is that even with that conclusion, the
oncologists continue to use these drugs on children.
Chemo is toxic and ineffective
After receiving
chemotherapy…"there were two toxic deaths. Median survival of the patients
with resistant or recurrent disease was 4.7 months… Conclusion: Alternative
strategies need to be developed for this highly lethal disease."
- Dunkel IJ, Garvin JH Jr; Goldman S, Ettinger LJ,
Kaplan AM, Cairo M, Li H, Boyett JM, Finlay JL. High dose chemotherapy with
autologous bone marrow rescue for children with diffuse pontine brain stem
tumors. J Neurooncol 1998; 37(1): 67-73.
Chemo and radiation cause an unknown amount of brain damage: Here, in
1998, comes another one of those ghastly admissions that the oncologists don’t
even know how much brain damage they are causing with their therapy.
"In the treatment of
children with brain tumors, balancing the efficacy of treatment against
commonly observed side effects is difficult because of a lack of quantitative
measures of brain damage…"
- Reddick WE, Mulhern RK, Elkin TD, Glass JO, Merchant
TE, Langston JW. A hybrid neural network analysis of subtle brain volume
differences in children surviving brain tumors. Magn Reson Imaging 1998
May; 16(4): 413-21.
Chemo provides "minimal success"
"For many years,
chemotherapy has been utilized for the treatment of malignant brain tumors with
minimal success."
-
Prados MD, Russo C: Chemotherapy of
brain tumors. Semin Surg Oncol 1998 Jan-Feb; 14(1): 88-95.
Orthodox therapy "has not improved survival"
"Aggressive treatment
of medulloblastoma, the most common pediatric brain tumor, has not improved
survival."
-
Weil MD, Lamborn K, Edwards MS, Wara
WM: Influence of a child’s sex on medulloblastoma outcome. JAMA 1998 May
13; 279(18): 1474-6.
Chemo causes cancer: Here we are in 1998 and "surprise"
more children are getting cancer from the chemotherapy the oncologists are
giving them. In this article the oncologists list the various secondary cancers
that their latest chemo experiment caused in their young victims.
"Diagnoses were choroid
plexus carcinoma (2 children), ependymoma (1 child), desmoplastic infantile
ganglioglioma (2 children), and medulloblastoma (1 child)…Three children
younger than 2 years old developed…myelodysplastic syndrome (2 children)…and
acute myelogenous leukemia (1 child)…Potential causative factors for this high
rate of secondary malignancies include prolonged use of alkylating agents and etoposide
(chemotherapy)…"
-
Duffner PK, Krischer JP, Horowitz ME,
Cohen ME, Burger PC, Friedman HS, Kun LE. Second malignancies in young children
with primary brain tumors following treatment with prolonged postoperative
chemotherapy and delayed irradiation: a Pediatric Oncology Group study. Ann
Neurol 1998 Sep; 44(3): 313-6.
But this should not be any surprise. Simply take a look at the articles
published years before (e.g. 1987, 1991 1997) that already described how
chemotherapy causes new cancers in children.
All of this information was published and known to oncologists when we
walked through the door with Alexander. This was the unimaginable history of a
highly toxic and ineffective treatment that we never suspected existed. None of
this information was shared with us. Instead we were told just the opposite -
that chemo would help Alexander because it has already helped thousands of
children before him.
What would our reaction have been if the oncologists had acted honestly and
said:
"Mr. and Mrs. Horwin,
there are chemotherapy drugs that we have been testing in children with brain
cancer for more than 20 years. The results, after all these years, suggest that
chemo is unproven and potentially dangerous in your son’s disease. In fact, we
have proof that it can cause secondary cancers such as other brain tumors and
various leukemia’s. Chances are that your son will not benefit appreciably by
this therapy. Most children his age with medulloblastoma die fairly quickly
even with administration of these drugs. In addition, because of the toxic side
effects of the drugs, Alexander will not enjoy a quality life. Since there is
no guaranty that the duration of his life will be significantly improved but
there is evidence that the quality of his life will be significantly hindered
we want you to make an informed decision. Feel free to try any non-toxic
therapy that you think may work or that will give Alexander quality of life. If
you wish to try chemo we are here for you. If you don’t wish to try chemo we
are still here for you and will provide MRI’s, blood tests, hospice care, etc.
Whatever we can do to help Alexander we would be happy to do."
Those honest words would have been "music to our ears." And yes,
we would have passed on the chemo. But that’s not how chemo was presented.
Instead, we were told that time was running out. We were told, not asked, but
told that we had 30 days from Alexander’s surgeries to start chemo. We were
told that chemo would offer Alexander a good chance of survival. We were told
that he would be getting a new chemo protocol with
"state-of-the-art" drugs. And we were warned that if we did not bring
Alexander in for chemotherapy a court order would be forthcoming so that the
oncologists could take him from us and administer these poisons without our
approval. We were lied to and threatened so that oncologists could fill our son
with deadly ineffective poisons that simply shortened his life and made his last
days on earth a living hell.
The oncologists did what they were trained to without challenging the death
that surrounds their treatments. The FDA took away Alexander’s freedom to use a
non-toxic and potentially life-saving therapy. The drug companies received
their chemotherapy profits. Alexander lost his life. And we have to live with
the knowledge that we never gave our son a fighting chance to survive his
disease
While Alexander was getting his chemo he would smile because he knew that
mommy and daddy were with him. "Alexander your job is to rest and let the
medicine work. Soon we are all going to go to the beach. Mommy and daddy and
Alexander, the team!" Alexander would open his eyes and force a smile.
"Yeah, the team," he would whisper.
A Child with cancer has the right
to…
The best non-toxic treatment
available in the world.
Stay with his parents without
threat of being taken away by the authorities.
Not to be subjected to experiments
that reduce him or her to a mere guinea pig.
Not to suffer.
Have quality of life.
-Raphaele & Michael Horwin
The following basic moral and
ethical concepts must be observed in medicine:
All experimental medical protocols
should be voluntary.
The experiment should be performed
to avoid unnecessary suffering.
No experiments should be conducted
where there is a belief that death or disabling
injury will occur except where the
experimental physicians also serve as subjects.
Proper preparations should be made
to protect the subjects even against remote possibility
of injury, disability or death.
The human subject should be at
liberty to bring the experiment to an end.
-Summarized from the Nuremberg
Code
Trials of War Criminals Before the
Nuremberg Military tribunals Under Control Council Law 10,
Volume 2, Nuremberg, October
1946-April 1949
Washington D.C., US Government
Printing Office, 1949; pp.181-182