http://www.nytimes.com/aponline/health/AP-Agent-Orange-Leukemia.html
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February 27, 2002 Panel Backs Off Agent Orange Finding
By THE ASSOCIATED PRESS
Filed at 5:36 p.m. ET WASHINGTON (AP) -- The Institute of Medicine is backing away from its
conclusion last year that the children of veterans exposed to Agent Orange
may have an increased chance of leukemia. The institute, part of the National Academy of Sciences, concluded Wednesday
there is not enough evidence to establish a connection between exposure and
development of acute myelogenous leukemia. This finding came after
researchers reviewed additional data, including a corrected Australian study. ``Obviously we're disappointed,'' said Len Selfon, director of veterans
benefits programs at Vietnam Veterans of America. ``We'll have to see what
they based the retraction of their original conclusion on.'' Veterans Affairs Secretary Anthony J. Principi said that for now, ``the
scientific evidence doesn't support'' a connection. He said he would support
benefits for these children ``if future studies reach the legal threshold.'' The institute reported last April that it had reviewed available studies
and concluded that the children of veterans exposed to herbicides such as
Agent Orange seemed to have an above average chance of developing that form
of leukemia. While the relationship between Agent Orange and various illnesses has been
debated for years, that was the first scientific connection between the
childhood disease and the pesticide. The finding stopped short of saying the
link was conclusive. In the new analysis, the researchers said an Australian study that was a
major factor in their earlier conclusion had an error ``that led its authors
to incorrectly conclude that these children faced significantly greater risk
of AML than the general population.'' When revised, that report found that the incidence of the disease among
the children of exposed veterans was slightly elevated, but within the range
of normal variation. In addition, the panel said it reviewed two small studies of pesticide
exposure from Norway and Germany that had not been included in the earlier
analysis. ``Our review of available studies, combined with the revised analysis from
Australia, indicates that the evidence is too weak to draw any conclusions or
even make tentative ones,'' said Irva Hertz-Picciotto, professor of
epidemiology at the University of California, Davis, who headed the panel. The report is the most recent in a series by the institute looking at the
effects of the herbicides used in Vietnam. During the Vietnam War, thousands of veterans were exposed to Agent
Orange, a defoliant used to clear areas of jungle so the Viet Cong could be
seen and attacked from the air. Acute myelogenous leukemia is a fast-spreading form of leukemia that
originates in bone-marrow cells. It accounts for nearly 700 cases of cancer
annually among children under 15. It is also known as acute myloid leukemia
and acute nonlymphocytic leukemia. Previous studies evaluated by the institute have found suggestive but not
conclusive evidence of a link between herbicide exposure and respiratory
cancers, prostate cancer, type two diabetes, spina bifida in children and
other conditions. The National Academy of Sciences is an independent organization chartered
by Congress to provide scientific advice to the government. ^------ On the Net: Institute of Medicine: http://national-academies.org
Department of Veterans Affairs: http://www.va.gov
Vietnam Veterans of America: http://www.vva.org ALL
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