With the release of the article in the Journal of Clinical
Pathology, entitled, “Potential viral pathogenic mechanism for new variant inflammatory
bowel disease” by V Uhlmann, CM Martin, O Shells, L Pilkington, I Silva, A
Killalea, SB Murch, AJ Wakefield and JJ O’Leary; another article has been
published linking measles virus with gut abnormalities with autism (1).
Dr. Vijendra Singh, Utah State University, Logan, Utah and
Dr. James Oleske, UMDNJ, Newark, New Jersey have found elevated measles
antibody titers in children with autism.
Elevated Rubeola Titers in Autistic Children
T Zecca, D. Graffino, M Lania-Howarth, M Passannante, J
Oleske NJ Medical school, Children’s Hospital of NJ, Newark, NJ September 1997
(presented at meeting with Dr. Marie Bristol at the National Institutes of
Health, Bethesda, Maryland)
The syndrome of autism is a clinical entity affecting 20
out of 10,000 children. we have evaluated the possible role of MMR in the
pathogenesis of autism by comparing rubeola titers in autistic and normal
children. Among 16 children diagnosed
with autism followed in our clinical practice, we noted these children to have
a 3 fold increase in their rubeola titers over expected normal range. A
Wilcoxon Kruskal Wallis test comparing 13 rubeola titers from normal children
reveals a statistically significant P-value of 0.0050. Subjectively, parents
have stated that their children’s developmental milestones deteriorated following
MMR vaccination. Neurological sequelae following MMR are widely reported. MMR
therefore may play a role in the pathogenesis of autism. The elevated titers of
anti-measles antibodies in autistic children may signify a chronic activation
of the immune system against this neurotropic virus.
“Serological Association of Measles Virus and Human
Herpesvirus-6 with Brain Autoantibodies in Autism.” Clinical Immunology and Immunopathology,
vol. 89, number 1, October 1998, pp. 105-8. This study is the first to report
an association between virus serology and brain autoantibody in autism: it
supports the hypothesis that a virus-induced autoimmune response may play a
casual role in autism. Vijendra Singh, Ph.D.
>From the US Department of Education (2):
Total Total
1992/1993 2000/2001 %
Increase
12,222 78,717 544%
Total Total
1992/1993 1999/2000 %
Increase
12,222 65,396
435%
Total Total
1992/1993 1998/1999 %
Increase
12,222 53,561
339%
Total Total
1992/1993 1997/1998 %
Increase
12,222 42,487
248%
Total Total
1992/1993 1996/1997 %
Increase
12,222 34,354
181%
Total Total
1992/1993 1995/1996 %
Increase
12,222 28,813
136%
(Source: Individuals with Disabilities Education Act data,
US Department of Education, ages 6-21)
Autism is increasing in epidemic proportions in the US and
in the UK. There has been denials by
government health officials and the medical establishment in the US and the UK,
that the MMR vaccine is causing autism. To date, there has been no clinical
science done by government health officials and medical establishment to prove
that the MMR vaccine is not causing autism.
We need the clinical science in order to prevent more
cases of autism and find immuno-therapeutic treatments that will help our
children who have been affected adversely and get them better. We need more independent
research to replicate the science of Dr. Wakefield, Dr. Singh and Dr. Oleske. Denials and opinion
reports do not replace clinical science. They certainly do not help our
children or stop the epidemic of autism.
Raymond Gallup, President
Autism Autoimmunity Project
45 Iroquois Avenue
Lake Hiawatha, NJ 07034
Tel 973 299-9162
References
(1) http://jcp.bmjjournals.com/cgi/content/full/55/1/DC1
(2) http://www.ideadata.org/tables24th\ar_aa3.htm
http://www.IDEAdata.org/tables/ar_aa2.htm
http://www.ed.gov/offices/OSERS/OSEP/Research/
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