http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11709761&form=6&db=m&dopt=r

 

Clin Infect Dis 2001 Dec 15;33 Suppl 4:S288-91

Related Articles, Books, LinkOut

How to make sense of pertussis immunogenicity data.

Olin P, Hallander HO, Gustafsson L, Reizenstein E, Storsaeter J.

Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Patrick.olin@smi.ki.se

Studies on serologic correlates to protection in pertussis were reviewed. Trials in the 1950s showed that agglutinogen titers correlated to protection of whole-cell vaccines, but postvaccination antibodies against pertussis toxin (PT) and against filamentous hemagglutinin did not in a later trial of acellular vaccines. However, in household studies nested in 2 recent trials, preexposure antibody levels against pertactin and against fimbriae correlated with protection against typical and mild pertussis, and anti-PT correlated only with protection against typical pertussis. These findings could be used by regulatory agencies to license pertussis vaccines. A reference laboratory for pertussis should distribute panels to control interlaboratory variation in recommended assays, and a minimal response should be set for each pertussis antigen. We conclude that 2 studies have shown correlates between measurable anti-pertactin, anti-fimbriae, and anti-PT antibody levels at exposure and individual protection against pertussis. We suggest that postvaccination response rates may be used as surrogate markers of protection.

Publication Types:

·         Review

·         Review, Tutorial

MeSH Terms:

·         Antibodies, Bacterial/blood

·         Antigens, Bacterial/immunology

·         Bacterial Outer Membrane Proteins/immunology

·         Biological Markers/blood

·         Case-Control Studies

·         Clinical Trials

·         Fimbriae, Bacterial/immunology

·         Human

·         Pertussis Toxins/immunology

·         Pertussis Vaccine/immunology*

·         Reference Standards

·         Support, U.S. Gov't, P.H.S.

·         Whooping Cough/prevention & control*

·         Whooping Cough/immunology

Substances:

·         Pertussis Toxins

·         pertactin

·         Pertussis Vaccine

·         Biological Markers

·         Bacterial Outer Membrane Proteins

·         Antigens, Bacterial

·         Antibodies, Bacterial

Grant support:

·         N01-AI-15125/AI/NIAID

PMID: 11709761 [PubMed - indexed for MEDLINE]

 

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