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PUBLIC SAFETY

·        Wakefield on BBC News, Stands bys MMR Claimes

·        Measles Outbreak Fears Grow

 

RESEARCH

·        Development And Mental Illness

·        Letter to the NY Times

 

 

 

Wakefield on BBC News, Stands bys MMR Claimes

http://news.bbc.co.uk/hi/english/audiovideo/programmes/panorama/newsid_17950

00/1795534.stm <-- address ends here

Wakefield stands by MMR claims Controversial doctor Andrew Wakefield is unrepentant about his conviction that the MMR vaccine may cause autism in some children.

Panorama investigates Dr Wakefield’s claims in the face of criticism that it is “bad science”.

Dr Wakefield first went public about his research in 1998. Parents’ confidence in MMR was severely dented and uptake of the vaccine began to fall.

“My concerns are that one more case of this is too many and that we put children at no more risk if we dissociate those vaccines into three but we may be averting the possibility of this problem,” he said.

From the moment he first voiced concerns over MMR, Andrew Wakefield has faced intense criticism from the Department of Health and the medical establishment. Reports from two expert committees have insisted the MMR vaccine is safe.

The pressure on Dr Wakefield to produce the evidence has been intense.

But it seems to have made him even more determined to carry on.

“When you’re taking on something like the establishment on the issue of the safety of a vaccine that has been hailed as being extremely safe, then you are inevitably going to come up against this kind of issue,” he said.

Safety tests In January 2000 Dr Wakefield published a new paper that questioned whether the MMR vaccine had ever been properly tested for safety.

He claimed the tests were too short to pick up long-term problems like autism. This highly controversial paper created another media storm and more confusion about MMR.

Before the study had even been published, the Department of Health went on the offensive. They launched a concerted attack on Wakefield’s credibility.

Dr Elizabeth Miller spoke at a government press conference in January 2001.

“There are no grounds for suspecting that MMR vaccine causes autism,” she said.

Family decision Dr Wakefield’s concerns about MMR have had a direct impact on his family. He and his wife, also a doctor, had to decide whether their own children should be given the triple jab.

Dr Wakefield’s wife, Carmel, told Panorama that their first two children were given the vaccine.

“But then as Andy’s work was unfolding and the potential link to MMR and problems began to unfold, then we had to reappraise our policy on vaccinating our own children, so our second two children have not had MMR vaccination,” she said.

In March 2001, Dr Wakefield went to Washington to give evidence before a Congressional committee investigating the potential link between MMR and autism.

Dr Elizabeth Miller Dr Miller, the British government’s representative, was in the audience to listen to Wakefield’s new evidence.  She came to present her own new evidence to refute his claims.

“There is no evidence that the onset of autistic symptoms is more likely shortly after MMR vaccine than at any other time,” she said.

“Indeed new evidence which is shortly to appear from my colleagues and myself in a vaccine journal is that there is no evidence that MMR vaccine increases the likelihood of autism at any time after vaccination.” Having spoken so publicly about his concerns about MMR there is growing pressure on Andrew Wakefield to produce some proof. Panorama reporter Sarah Barclay separates fact from fiction in the war on words in this important part of public health policy.

Watch ‘MMR: Every Parents Choice’ at 2215GMT [2:15pm pst] on Sunday on BBC One or via a live stream on this site.

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Measles Outbreak Fears Grow

http://news.bbc.co.uk/hi/english/health/newsid_1795000/1795625.stm <- - address ends here.

Fears of a measles outbreak in south London are growing after series of cases, including one which left a toddler dangerously ill.

Measles has been confirmed in three children, and health officials expect up to 22 others will also test positive for the infection.

The cluster of cases reinforces the danger of measles, which in the most extreme cases - one in 8,000 - can prove fatal.

Lambeth, Southwark and Lewisham has a very low uptake figure for the controversial Measles, Mumps and Rubella (MMR) vaccine.

Toddler Clara Forbes had to be rushed to intensive care after developing the virus.

She is now recovering, although her mother Hazel said that her condition had been “touch and go” with initial fears that the virus could move to her brain.

Clara, who is 16 months old, should have had her MMR, but her mother had delayed the immunisation.

Mrs Forbes said: “She got measles pneumonia and it almost went into her brain and it was really touch and go.” “My two elder children of three and five had both been vaccinated and she hadn’t been vaccinated but she will be the moment she is better.

“I had put it off in December because she had had a cold and I said I’ll do it in January or when she is better.”

The health authority is taking this opportunity to remind parents of

the need to protect their children from these potentially dangerous

childhood diseases

Lambeth Southwark & Lewisham HA A spokeswoman for White House School in Clapham, which takes children aged two to nine, confirmed to BBC News Online there had been one case of measles at the school.

She added: “We have been giving the parents information which is coming from the health authority.” Public health experts said a cluster of three cases in an area with low MMR uptake was to be expected. However, there will be concern if the number of confirmed cases rise.

On average, there are fewer than 100 cases of measles nationally each year.

Lambeth, Southwark and Lewisham Health Authority say the 22 children who are being investigated have symptoms which could be early signs of measles, but which could also be signs of other conditions.

Some in this group are also believed not to have the MMR jab.

Environmental health officers are taking saliva swabs from the

children to test for measles. Results are due early next week.

Low uptake Lambeth, Southwark and Lewisham Health Authority said the latest uptake figure for MMR in the three months up to September 2001 in the area is 65%.

The latest figures from the Public Health Laboratory Service for the year from April 2000 to March 2001 show 73% of children in that area had been vaccinated before their second birthday.

The figure for 1990 to 2000 was 76%.

In contrast, the latest national figures, released on Friday, showed

an average uptake of 90.9%.

MMR can protect 90% of all children who have had the first vaccination, a second dose raises the level of protection from measles to 99%.

Alert GPs and A&E doctors in Lambeth, Southwark and Lewisham have been alerted to the local situation and parents in affected schools have also received letters from the health authority.

It recently emerged that doctors in north Cheshire were concerned because uptake of the MMR vaccine there had fallen to 77%.

This is well below the national average - and about the same level as in Dublin last year when there was a serious measles outbreak.

There have been fears over a link between the MMR vaccine and autism which have deterred some parents from having their children vaccinated.

Lambeth Southwark and Lewisham Health Authority said in a statement:

“The health authority is taking this opportunity to remind parents of the need to protect their children from these potentially dangerous childhood diseases and is strongly recommending that all children should have their MMR vaccine which is safe and effective.” The prime minister’s official spokesman earlier reinforced Mr Blair’s support for the vaccine.

Dr Liam Fox MP, Shadow Health Secretary, said: “The government’s immunisation policy is a public health disaster.

“Labour health ministers have simply failed to grasp the importance of establishing public confidence in the MMR vaccine.” Liberal Democrat health spokesman Evan Harris said: “All the evidence is that MMR is safe and effective, while history tells us that measles in unvaccinated populations can be serious and sometimes disabling or even fatal.”

 

 

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Development And Mental Illness

Paul H. Patterson

Current Opinion in Neurobiology, 2002, 12:1:115-118 [Not available on PubMed.]

Direct viral infection of the developing brain can have disastrous consequences for the fetus. More subtle and perhaps more insidious are viral infections of the pregnant mother, which can have long-lasting effects such as an increased risk of schizophrenia in the offspring.

A recent mouse model has shown that respiratory infection in the pregnant mother leads to marked behavioral and pharmacological abnormalities in the offspring, some of which are relevant for schizophrenia and autism.  This effect on fetal brain development might be caused by the maternal antiviral immune response, possibly mediated by cytokines.

* * *

 

NY Times letter: An Autistic Artist

January 22, 2002

 

An Artist’s Success at 14, Despite Autism (January 16, 2002)

To the Editor:

It was delightful to read an article about the “lighter” side of autism, a very debilitating disorder that is on the rise around the country (“Success at 14, Despite Autism,” Arts pages, Jan. 16).

It is known that autistic children have difficulty with object permanence, and therefore it has been deemed that autistics do not “see faces.” Clearly Jonathan Lerman, the artist profiled in the article, sees faces.

It is also important to note that while his I.Q. was measured at 53, the low number can likely be in part attributed to his inability to be tested. A common mistake in regard to autistic children is to consider them mentally retarded when they are actually speech, motor and developmentally disabled.

Let us not relegate autistic children to the ranks of the mentally retarded. Yeah for Jonathan! I hope to buy one of his drawings for my office.

Joan Fallon

[The writer is a pediatric chiropractor who works with autistic children.

 

 

 

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