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Study Links Measles Virus To New Form Of Bowel Disease

http://www.reutershealth.com/cgi-bin/frame2?top=/tops/med.html&left=/medl.html&right=/archive/2002/02/05/professional/links/20020205clin009.html

London - Britain’s Department of Health said on Tuesday that a new study showing that the measles virus is present in children with a new variant inflammatory bowel disease does not mean that the disease is linked to the measles, mumps and rubella (MMR) vaccine.

As controversy over the safety of MMR continues to rage in the UK, a Ministry spokeswoman told Reuters Health: “We will consider this research as we always do. But it does not show a link with MMR vaccine.”

The latest research was posted in full on the Internet at http://www.molpath.com after some findings were broadcast during a BBC television investigation of MMR on Sunday. The study will be published in the April issue of Molecular Pathology.

The authors include Andrew J. Wakefield, whose work at London’s Royal Free Hospital in 1998 first raised fears that MMR vaccination may trigger bowel disorders and autism in susceptible children.

The study was set up to investigate the presence of persistent measles virus in children with ileocolonic lymphonodular hyperplasia, which has been described in a cohort of children with developmental disorder.

The results showed that 75 of 91 patients with a confirmed diagnosis of ileocolonic lymphonodular hyperplasia and enterocolitis were positive for measles virus in their intestinal tissue compared with only 5 of 70 control patients.

“The data confirm an association between the presence of measles virus and gut pathology in children with developmental disorder,” Professor John J. O’Leary of Coombe Women’s Hospital in Dublin and associates conclude. The authors suggest that the virus may act as an immunological trigger.

In a statement, Prof. O’Leary stressed that the research did not set out to investigate the role of MMR in the development of either bowel disease or developmental disorder, and “no conclusions about such a role could, or should be, drawn from our findings.”

An accompanying editorial also advises against jumping to any hasty conclusions about MMR.

“We are all aware of the public unease about a potential link between vaccination with the triple vaccine MMR...and autism or bowel inflammatory conditions, with some hundreds of parents of afflicted children undertaking legal action against the manufacturers,” Drs. A. Morris and D. Aldulaimi of the University of Warwick write.

But they add that it would be “entirely wrong” to jump to the conclusion that the measles component of MMR causes the colitis or development disorder. “Most if not all diseases are multifactorial in nature, and the data here could equally be interpreted as indicating that the colitis or developmental disorder ‘cause’ the persistence of the measles.”

The editors of Molecular Pathology, Professor John Crocker and Dr.  David Burnett, said that the research was an important piece of work that draws conclusions entirely consistent with the data, but that any link with MMR is not justified.

J Clin Pathol: Mol Pathol 2002:55;0-6.

The new Wakefield article can be viewed at:

http://jcp.bmjjournals.com/cgi/content/full/55/1/DC1

COMMENTARY BY LENNY SHAFER OF FEAT (Families for Early Autsim Treatment)

http://www.feat.org

US Media Reaction to Wakefield Study: News Blankout Almost Total

Going into the third day since medical researcher Andrew Wakefield dropped a news concussion bomb with the publishing of his latest findings of measles virus in 83% of autistic children, there has been virtually a news black out in the US.  With a singular expectation, there has been no news in the press about the latest development of an issue in the UK that has drawn in the government, the Prime Minister, his infant son, and at least 2000 families with late onset autism, the hyperbolic British press and the national health maintenance system into a raging public Health debate.

The single report that we were able to find outside Europe and the rest of the world, is a Reuter’s piece directed to professionals and not consumers.  The article leaves autism out of the copy nearly altogether.  The article, with its curious spin is provided here below for the reader’s aghast.

Also included below is a commentary from the medical science journal where Wakefield has published his new research, which urges the public not to hysterically leap to conclusions and read too much into this latest information.  The message is that Wakefield’s work does not, they repeat, does not prove that MMR vaccines cause autism, a point Wakefield did not even attempt to make in this research, however.

“It doesn’t prove causation” agrees Barbara Loe Fisher of the National Vaccine Information Center, “but it does go a long way to show an association.”  In other word, we arguably have a smoking gun.

The defenders can continue to argue that there is no solid proof of a connection between vaccines and autism.  However, there is enough evidence for a serious hypothesis.  Given this latest addition to the puzzle of autism’s etiology, it is now time for our public health officials to finally shift their focus from spending the public’s money on research designed only to defend vaccines, to research designed to get at the at the cause of autism.

The time is over for increasingly silly dismissals of the autism epidemic.  The time is over to utterly ignore the eyewitness experiences of hundreds to thousands of parents who have seen the children slip away only after the injections.  The time is over for simply insisting that there is no proof of a connection between certain vaccines and autism.  This is not enough, for there is indeed plenty of evidence to suggest there might be.  For public health officials to remain complacent in the face of this growing evidence is simply not acceptable.

If our hypothesis about the causes of autism prove to be wrong as the defenders insist, for us it will be back to the drawing board, for we cannot join them in their complacency.  But if they prove to be wrong one cannot imagine the consequences.  For after we find the cause, treatment and cure for autism, there will be some matters of justice that wait.

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