Vaccines: Are they worth risk?
As
military prepares to receive smallpox shots, debate over benefits and
side effects of vaccines grows
By
DAVID WAHLBERG
Atlanta Journal-Constitution Staff Writer
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SIDE EFFECTS VARY WIDELY Immunizations health
authorities recommend for some or all adults:
INFLUENZA
Recommended for those
age 50 or older; health care workers; people with diabetes,
heart or lung disease, HIV infection and other conditions;
pregnant women past the first trimester during flu season;
anyone concerned about the flu.
Pros: 70 percent
protection against three strains of flu, which kills 20,000
people a year, mostly the elderly.
Cons: occasional
allergic reactions; rarely, the temporary paralytic illness
Guillain-Barrι syndrome.
TETANUS
Recommended for all
adults every 10 years.
Pros: Protects
against "lockjaw," a sometimes fatal disease caused by a
toxin in spores that can live for years in soil and animal
feces.
Cons: soreness
and swelling; occasional muscle wasting in arms.
PNEUMONIA
Recommended for those
65 or older; health care workers; people with diabetes,
heart or lung disease, HIV and other conditions; anyone
concerned about pneumonia.
Pros: can
prevent pneumonia, meningitis and ear and blood infections.
Cons: swelling
and fever; occasional allergic reactions including
dizziness, hives or rapid heart rate.
MENINGITIS
Recommended for college
freshmen; travelers to Africa or the Middle East; people
with some medical conditions.
Pros: protects
against meningitis, a brain-swelling disease that sometimes
occurs among people living in close quarters such as college
dormitories.
Cons: redness,
pain, fever.
HEPATITIS B
Recommended for health
care workers; dialysis patients; intravenous drug users; gay
men; people with multiple sex partners.
Pros: can
prevent short-term illness that includes diarrhea and
vomiting and also long-term liver disease.
Cons: soreness,
fever, allergic reactions; some claim it can cause
auto-immune problems.
CHICKENPOX
Recommended for adults
with no history of chickenpox; health care workers; day care
providers; not for pregnant women or people with AIDS or
other immune deficiencies.
Pros: can
prevent the pox-forming disease, which is much more serious
in adults than in children.
Cons: rarely,
seizures and pneumonia; recent reports say protection
doesn't last as long as expected, meaning booster shots may
soon be required.
MMR (MEASLES, MUMPS AND RUBELLA)
Recommended for adults
with no reliable history of the diseases or vaccination for
them; not for pregnant women or people with AIDS or other
immune deficiencies.
Pros: can
prevent three childhood diseases common before the vaccine
was developed.
Cons: fever,
rash, swollen glands; occasional seizures and allergic
reaction; rarely, coma or brain damage; some claim a
connection with autism in children, though many studies
dispute that.
Sources: Centers for Disease Control and Prevention;
National Vaccine Information Center
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Is an ounce
of prevention worth a pound of cure if the ounce is a vaccine that can
cause serious side effects, including death?
That's a question many people are asking after President Bush on
Friday ordered members of the military serving in high-risk areas to be
vaccinated against smallpox and said he will be inoculated as well. But
he said that for most people, the risk of bioterrorism is too small to
warrant vaccinations.
Bush's decision, delayed for months while the federal government
weighed the risks of the smallpox vaccine, has sharpened the public
health focus on all adult vaccinations. The question of whether healthy
adults should get preventive shots, and when, extends to the vaccines
for influenza, pneumonia, meningitis, tetanus and hepatitis B, as well
as two vaccines for people who aren't sure whether they had the diseases
or shots in childhood: chickenpox and measles, mumps and rubella (MMR).
Other immunizations sometimes debated are those for Lyme disease,
although that vaccine is no longer available in the United States, and
anthrax, which has been used primarily in the military and is not
available to the general public.
Most health officials say that people should seriously consider the
risks before being vaccinated for smallpox but advocate getting other
recommended adult vaccinations.
Smallpox was eradicated in 1980, but government officials worry that
some of the virus may have fallen into the hands of terrorists.
One-third of those infected in a smallpox outbreak could die. But
smallpox vaccination also poses serious risks. One to two of every
million people vaccinated for smallpox will die from the vaccination,
and many more will suffer serious reactions, according to the Centers
for Disease Control and Prevention.
Some experts say those figures are actually higher, because today's
population includes more people with immune deficiencies caused by the
AIDS virus, cancer chemotherapy and other factors than when smallpox
vaccinations were last routinely administered decades ago.
"A smallpox outbreak is only a theoretical risk, but the risks of the
vaccine are real," said Dr. Carlos del Rio, chief of medicine at Grady
Memorial Hospital in Atlanta and an associate professor of infectious
diseases at Emory University. "We should use this concern about smallpox
as an opportunity to think about getting vaccinated against the diseases
we may actually get, like influenza and pneumonia."
Others are concerned that by getting vaccinations, even those
considered routine, people are subjecting themselves to more and more
antibodies without knowing whether interactions among various vaccines
can cause damage.
The CDC studies each vaccine's side effects, but few researchers have
looked at their aggregate effects, partly because widespread use of some
vaccines is relatively new.
Some concerned parents maintain that childhood vaccinations are
linked with certain adverse health outcomes, though most scientists deny
it. Examples include alleged links between the MMR vaccine and autism
and between the diphtheria, tetanus and pertussis vaccine and sudden
infant death syndrome.
Some groups are now speaking out on adult vaccines, too.
"We have not done a good enough job of evaluating the potential
long-term effects of using vaccines to prevent all of these communicable
diseases," said Barbara Loe Fisher, president of the National Vaccine
Information Center, based in Virginia. Fisher questions why, for
example, nearly all age groups are being encouraged to get the influenza
vaccine, when it was initially targeted to the elderly, who are most at
risk for flu.
"It seems like we've gotten into the pattern that more is better when
it comes to vaccines, but the public health officials never take a step
back and ask if that is wise," Fisher said. "The companies that make the
vaccine put their time and money into it and want to have it used."
The flu vaccine was initially directed at the elderly because the
supply was limited, del Rio said. He said there are no proven risks from
receiving several different vaccines.
"Antibodies are good," del Rio said. "Most of these vaccines have
been around a long time."
Joan Hart of Marietta wasn't worried about side effects when she
received a smallpox vaccination last month as part of a study by
Serologicals Inc. of Smyrna. The company is drawing blood plasma from
recently vaccinated people to use in making a treatment for vaccine
reactions.
"I'm not a skittish type of person, so it didn't bother me," said
Hart, 53, a hairstylist.
She had some redness on her arm after the vaccination but no other
side effects, she said. Because the pustule that forms around the
vaccination site can be contagious, she was told not to be near pregnant
women or young children.
"I was supposed to have Thanksgiving dinner with my sister and her
pregnant daughter in Birmingham, but I didn't go," Hart said. "But that
was really the only issue."
Randell Baker, a billing coordinator at the Emory University School
of Medicine, got an influenza shot last month, as he has in most recent
years.
"I tried it one year and still got the flu, but it wasn't as bad as
before," said Baker, 38. "Then I stopped doing it, and I got the flu
worse. So I just started doing it every year."
If the smallpox vaccine is offered to the general public, Baker said
he'll probably get it.
"I'd want to be protected," he said. "But a lot of it would depend on
what the world situation is at the time."
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