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Vaccines: Are they worth risk?
As military prepares to receive smallpox shots, debate over benefits and side effects of vaccines grows

By DAVID WAHLBERG
Atlanta Journal-Constitution Staff Writer

YOUR TURN

Do you think vaccinations for adults are worth the risk?
  Generally, yes. I want to be protected. 47% 313
  For something common, like the flu, yes. But for smallpox? No. 22% 144
  Generally no. The prevention can be worse than the disease. 32% 211
Total Votes   668

This survey is not a scientific sampling and does not reflect the opinion of the general public, but only of those who choose to participate.


SIDE EFFECTS VARY WIDELY

Immunizations health authorities recommend for some or all adults:

 

INFLUENZA

-- Recommended for those age 50 or older; health care workers; people with diabetes, heart or lung disease, HIV infection and other conditions; pregnant women past the first trimester during flu season; anyone concerned about the flu.

-- Pros: 70 percent protection against three strains of flu, which kills 20,000 people a year, mostly the elderly.

-- Cons: occasional allergic reactions; rarely, the temporary paralytic illness Guillain-Barrι syndrome.

TETANUS

-- Recommended for all adults every 10 years.

-- Pros: Protects against "lockjaw," a sometimes fatal disease caused by a toxin in spores that can live for years in soil and animal feces.

-- Cons: soreness and swelling; occasional muscle wasting in arms.

PNEUMONIA

-- Recommended for those 65 or older; health care workers; people with diabetes, heart or lung disease, HIV and other conditions; anyone concerned about pneumonia.

-- Pros: can prevent pneumonia, meningitis and ear and blood infections.

-- Cons: swelling and fever; occasional allergic reactions including dizziness, hives or rapid heart rate.

 

MENINGITIS

-- Recommended for college freshmen; travelers to Africa or the Middle East; people with some medical conditions.

-- Pros: protects against meningitis, a brain-swelling disease that sometimes occurs among people living in close quarters such as college dormitories.

-- Cons: redness, pain, fever.

HEPATITIS B

-- Recommended for health care workers; dialysis patients; intravenous drug users; gay men; people with multiple sex partners.

-- Pros: can prevent short-term illness that includes diarrhea and vomiting and also long-term liver disease.

-- Cons: soreness, fever, allergic reactions; some claim it can cause auto-immune problems.

CHICKENPOX

-- Recommended for adults with no history of chickenpox; health care workers; day care providers; not for pregnant women or people with AIDS or other immune deficiencies.

-- Pros: can prevent the pox-forming disease, which is much more serious in adults than in children.

-- Cons: rarely, seizures and pneumonia; recent reports say protection doesn't last as long as expected, meaning booster shots may soon be required.

MMR (MEASLES, MUMPS AND RUBELLA)

-- Recommended for adults with no reliable history of the diseases or vaccination for them; not for pregnant women or people with AIDS or other immune deficiencies.

-- Pros: can prevent three childhood diseases common before the vaccine was developed.

-- Cons: fever, rash, swollen glands; occasional seizures and allergic reaction; rarely, coma or brain damage; some claim a connection with autism in children, though many studies dispute that.

Sources: Centers for Disease Control and Prevention; National Vaccine Information Center

• More Healthy Living

Is an ounce of prevention worth a pound of cure if the ounce is a vaccine that can cause serious side effects, including death?

 

That's a question many people are asking after President Bush on Friday ordered members of the military serving in high-risk areas to be vaccinated against smallpox and said he will be inoculated as well. But he said that for most people, the risk of bioterrorism is too small to warrant vaccinations.

Bush's decision, delayed for months while the federal government weighed the risks of the smallpox vaccine, has sharpened the public health focus on all adult vaccinations. The question of whether healthy adults should get preventive shots, and when, extends to the vaccines for influenza, pneumonia, meningitis, tetanus and hepatitis B, as well as two vaccines for people who aren't sure whether they had the diseases or shots in childhood: chickenpox and measles, mumps and rubella (MMR).

Other immunizations sometimes debated are those for Lyme disease, although that vaccine is no longer available in the United States, and anthrax, which has been used primarily in the military and is not available to the general public.

Most health officials say that people should seriously consider the risks before being vaccinated for smallpox but advocate getting other recommended adult vaccinations.

Smallpox was eradicated in 1980, but government officials worry that some of the virus may have fallen into the hands of terrorists. One-third of those infected in a smallpox outbreak could die. But smallpox vaccination also poses serious risks. One to two of every million people vaccinated for smallpox will die from the vaccination, and many more will suffer serious reactions, according to the Centers for Disease Control and Prevention.

Some experts say those figures are actually higher, because today's population includes more people with immune deficiencies caused by the AIDS virus, cancer chemotherapy and other factors than when smallpox vaccinations were last routinely administered decades ago.

"A smallpox outbreak is only a theoretical risk, but the risks of the vaccine are real," said Dr. Carlos del Rio, chief of medicine at Grady Memorial Hospital in Atlanta and an associate professor of infectious diseases at Emory University. "We should use this concern about smallpox as an opportunity to think about getting vaccinated against the diseases we may actually get, like influenza and pneumonia."

Others are concerned that by getting vaccinations, even those considered routine, people are subjecting themselves to more and more antibodies without knowing whether interactions among various vaccines can cause damage.

The CDC studies each vaccine's side effects, but few researchers have looked at their aggregate effects, partly because widespread use of some vaccines is relatively new.

Some concerned parents maintain that childhood vaccinations are linked with certain adverse health outcomes, though most scientists deny it. Examples include alleged links between the MMR vaccine and autism and between the diphtheria, tetanus and pertussis vaccine and sudden infant death syndrome.

Some groups are now speaking out on adult vaccines, too.

"We have not done a good enough job of evaluating the potential long-term effects of using vaccines to prevent all of these communicable diseases," said Barbara Loe Fisher, president of the National Vaccine Information Center, based in Virginia. Fisher questions why, for example, nearly all age groups are being encouraged to get the influenza vaccine, when it was initially targeted to the elderly, who are most at risk for flu.

"It seems like we've gotten into the pattern that more is better when it comes to vaccines, but the public health officials never take a step back and ask if that is wise," Fisher said. "The companies that make the vaccine put their time and money into it and want to have it used."

The flu vaccine was initially directed at the elderly because the supply was limited, del Rio said. He said there are no proven risks from receiving several different vaccines.

"Antibodies are good," del Rio said. "Most of these vaccines have been around a long time."

Joan Hart of Marietta wasn't worried about side effects when she received a smallpox vaccination last month as part of a study by Serologicals Inc. of Smyrna. The company is drawing blood plasma from recently vaccinated people to use in making a treatment for vaccine reactions.

"I'm not a skittish type of person, so it didn't bother me," said Hart, 53, a hairstylist.

She had some redness on her arm after the vaccination but no other side effects, she said. Because the pustule that forms around the vaccination site can be contagious, she was told not to be near pregnant women or young children.

"I was supposed to have Thanksgiving dinner with my sister and her pregnant daughter in Birmingham, but I didn't go," Hart said. "But that was really the only issue."

Randell Baker, a billing coordinator at the Emory University School of Medicine, got an influenza shot last month, as he has in most recent years.

"I tried it one year and still got the flu, but it wasn't as bad as before," said Baker, 38. "Then I stopped doing it, and I got the flu worse. So I just started doing it every year."

If the smallpox vaccine is offered to the general public, Baker said he'll probably get it.

"I'd want to be protected," he said. "But a lot of it would depend on what the world situation is at the time."



 


 

 

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Vaccination News Home Page

ALL INFORMATION, DATA, AND MATERIAL CONTAINED, PRESENTED, OR PROVIDED HERE IS FOR GENERAL INFORMATION PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS REFLECTING THE KNOWLEDGE OR OPINIONS OF THE PUBLISHER, AND IS NOT TO BE CONSTRUED OR INTENDED AS PROVIDING MEDICAL OR LEGAL ADVICE.  THE DECISION WHETHER OR NOT TO VACCINATE IS AN IMPORTANT AND COMPLEX ISSUE AND SHOULD BE MADE BY YOU, AND YOU ALONE, IN CONSULTATION WITH YOUR HEALTH CARE PROVIDER.