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http://www.nature.com/cgi-taf/Gateway.taf?g=5&file=/drugdisc/news/articles/d291102-1.html&filetype=&_UserReference=

Doubts raised over HIV vaccine therapy
A patient undergoing therapy to elicit immunity to one strain of HIV has become infected with another strain — a finding that has caused concerns about the potential effectiveness of HIV vaccines. The patient was on stop-start therapy, in which anti–HIV drugs are taken until the virus is suppressed. The treatment is stopped, allowing the immune system to attack replicating HIV, and when the immune system becomes overwhelmed, the treatment is continued. But the finding that other HIV strains can infect an 'immunized' patient could be a huge blow for HIV vaccine development, and researchers now have to find out whether this is a rare or common event in this treatment strategy (Nature 420, 434-439 (2002)).

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