http://www.pediatrics.org/cgi/content/abstract/110/6/e77
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PEDIATRICS Vol. 110 No. 6 December 2002, pp. e77
ELECTRONIC ARTICLE |
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* Channing Laboratory, Department of Medicine, Brigham and Women’s
Hospital, Boston, Massachusetts
Division of
Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center,
Boston, Massachusetts
Harvard Medical School,
Boston, Massachusetts
|| Harvard School of Public Health, Boston, Massachusetts
¶ Dana-Farber Cancer Institute, Boston, Massachusetts
Objective. Bottle feeding in the bed or crib before sleep time has been associated with an increased risk of wheezing in the first year of life. We examined whether bottle feeding in the bed or crib before sleep time in the first year of life is associated with wheezing in the first 5 years of life.
Methods. In a prospective cohort study of 448 children with
parental history of atopy followed from birth, we examined the
relation between the number of bimonthly parental reports of bottle
feeding in the bed or crib before sleep time in the first year of
life (range: 0–6 reports) and parental report of wheezing in the
first 5 years of life. Additional outcome measures included recurrent
wheezing (
2 episodes of wheezing
in the previous year) and asthma (physician-diagnosed asthma
and
1 episode of wheezing in the
previous year) at the age of 5 years.
Results. The risk of recurrent wheezing and asthma at 5 years of age increased significantly with each additional report of bottle feeding in the bed or crib before sleep time in the first year of life. The risk of wheezing between the ages of 1 and 5 years increased with each additional report of bottle feeding in the bed or crib before sleep time in the first year of life. As an example, a child whose parents reported bottle feeding in the bed or crib before sleep time on 3 occasions in the first year of life had 1.5 times higher risk of wheezing between the ages of 1 and 5 years than a child whose parents did not report bottle feeding in the bed or crib before sleep time in the first year of life (95% confidence interval for relative risk: 1.12–2.12).
Conclusions. Among children with parental history of atopy, bottle feeding in the bed or crib before sleep time in the first year of life is a risk factor for recurrent wheezing and asthma at 5 years of age and a risk factor for wheezing between the ages of 1 and 5 years.
Key Words: bottle feeding • sleep time • wheezing
Abbreviations: IgE, immunoglobulin E • OR, odds ratio • CI, confidence interval • GER, gastroesophageal reflux
Received for publication May 16, 2002; accepted Aug 26, 2002.
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