Adverse reactions after injection of adsorbed
diphtheria-pertussis-tetanus (DPT) vaccine are not due only to pertussis
organisms or pertussis components in the vaccine.
Gupta RK, Relyveld EH.
National Institutes of Health, Bethesda, MD 20892.
Reactions to adsorbed diphtheria-pertussis-tetanus (DPT) vaccine have mostly
been attributed to the pertussis organisms or pertussis components in the
vaccine. Nevertheless reactions may also be due to other factors such as
sensitization induced by aluminium adjuvants and impurities present in crude
toxoids that cannot be removed by purification of toxoids after formalinization.
Aluminium compounds such as aluminium phosphate and aluminium hydroxide are the
most commonly used adjuvants with vaccines for human use. Due to the increasing
concern about the toxicity of aluminium, other adjuvants like calcium phosphate
may be evaluated as an alternative to aluminium adjuvants. To minimize reactions
after immunization with DPT vaccine due to impurities in the toxoids, the use of
toxoided purified toxins is suggested.
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