Childhood
epileptic seizures and cerebral palsy induced by hepatitis B vaccines: Case
report
Presented at the 2nd International Symposium on Hyperbaric
Oxygenation for Cerebral Palsy and the Brain-Injured Child
Boca Raton, Florida
July 25-28, 2001
Campbell AW, MD**, Anyanwu E, MS, PhD**, High W, MD, PhD**,
Vojdani A. MT, PhD*
**Center for Immune, Environmental & Toxic Disorders
25010 Oakhurst, Suite 200, Spring, Texas 77386; Tel:
281-364-1013 Fax: 281-364-0492.
*Immunosciences
Lab, Incorporated, Beverly Hills, California.
Center for Immune, Environmental & Toxic Disorders
25010 Oakhurst, Suite 200, Spring, Texas 77386; Tel:
281-364-1013 Fax: 281-364-0492.
Abstract
Purpose:
The causal involvement of adverse hepatitis B vaccines in cerebral palsy and
epilepsy, remains controversial. In this study, we report a case report of a 21
month-old white female patient who presented with recurrent seizures and
manifested all characteristic features of cerebral palsy as a result of
hepatitis B vaccines. Methods:
neuroimmunologic techniques, family history, and previous medical records were
used to evaluate, correlate and ascertain whether cerebral palsy and epilepsy
were a consequence of hepatitis B vaccines adverse effects. Results: Abnormal EEG showed
bilateral cerebral hemispheric disturbances with abnormal rhythmic and
irregular delta wave activity was present suggesting an underlying cortical
rhythms, less evident in the area of involvement. Furthermore, there was 4 Hz,
paroxysmal bilaterally synchronous generalized focal theta activity suggesting
damage to a non-specific thalmo-cortical region. Also, multiple theta wave
discharges were seen independently arising from different regions of the
hemispheres suggesting several potentially epileptogenic foci. The immunologic
evaluation showed multiple antibody abnormalities including T helper/suppressor
ratio and immune complexes. Certain abnormal antibodies found in epilepsy (IgG,
IgA) were present in all the patients. There was an elevation of Mg2+ ions receptor
function probably, as a result of autoimmune dysfunction. Conclusions:
Since there were no known family history of individuals with developmental
problems, mental retardation, or seizure disorders, it then meant that her
health condition was related to after birth events. Hence, those abnormalities that are associated with neurological
dysfunctions, and characteristics that are found in cerebral palsy and
epilepsy, are most likely associated with hepatitis B vaccines adverse effects
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