drug that lowers cholesterol also reduces inflammation of blood
vessels, a study being published today has found, and does so
quickly enough that the drug may find a new role in treating heart
attacks.
In recent years, research has suggested that inflammation may
rank alongside high cholesterol as a possible cause of heart
disease. Inflammation also causes complications after heart attacks
and heart surgery.
For instance, among people who had angioplasty, a common kind of
heart surgery, those with high levels of inflammation were four
times as likely to die of complications, according to figures cited
in the article, which was published in the journal Circulation.
In the study, 20 people with high cholesterol levels were given
the drug simvastatin for 14 days each and then given a placebo for
another 14 days. Another 20 people were given the pills for the same
times, but in the reverse order. The simvastatin reduced the levels
of harmful cholesterol and lowered by more than a third the levels
of a blood chemical that shows a patient has inflammation. The
placebo had no effect.
Simvastatin and similar drugs, which are called statins, are
generally used as long-term treatments to lower the risk of heart
disease. But an author of the study, Dr. Robert H. Eckel of the
University of Colorado Health Sciences Center in Denver, said the
fast action of the simvastatin in lowering the inflammation raised a
possibility that statins could be used for acute illness, too.
"If you can intervene at the time when somebody is in the
emergency room and lessen the rise of inflammation" that would
probably cut deaths, he said, although he added that the theory
needed to be tested.
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