Aspirin, already known to reduce the risk of colon cancer, may also prevent
cancer of thepancreas.
In a seven year study of more than 28000 postmenopausal women aged 55 to
69 who were participants in the Iowa women's healthstudy, the risk
of pancreatic cancer was 43% lower in women whotook aspirin or
products containing aspirin than in women whodid not (relative risk
0.57 (95% confidence interval 0.36 to 0.90)).The more often that
women took aspirin, the lower their risk ofthe cancer (Journalof the National Cancer Institute 2002;94:1168-71)[Abstract/Full
A decreased incidence of pancreatic cancer with use of non-steroidal
anti-inflammatory drugs (NSAIDs) has been shown by otherstudies, all
of which were studies of patients taking NSAIDs forother
indications, such as rheumatoid arthritis. This is the firststudy to
directly examine the relation between aspirin use andpancreaticcancer.
The study showed that the protective effects of aspirin increased with
frequency of use. Compared with women who never tookaspirin, women
who took aspirin 2-5 times a week had a 53% lowerrisk and women who
took it 6 times a week had a 60%
The study's lead author, Dr Kristin Anderson of the University of Minnesota
in Minneapolis, said she and her colleagues "triedto make the
effects of aspirin go away" by taking into accountcharacteristics of
the women that could have influenced the results,such as age, the
presence of diabetes, and whether they smokedor took multivitamins.
"Nothing made the aspirin effect go away,"Dr Anderson
While the mechanism by which aspirin could reduce the incidence of pancreatic
cancer is not clear, it is thought to involveinhibition of
expression of cyclo-oxygenase 2but
it probablyinvolves other mechanisms as well, say the researchers.
In thestudy, other NSAIDs, such as ibuprofen, did not decrease the
incidenceof pancreatic cancer, perhaps reflecting differences in
theirmechanism of action, said DrAnderson.
She cautioned, however, that the researchers did not have enough evidence to
rule out that other NSAIDs may reduce the riskof pancreatic cancer.
She said that the women in the study wereasked in 1992 about their
use of NSAIDs, when the drugs were notas widely used and some newer
types had not yet beenintroduced.
The researchers did not collect data on the dose of aspirin the participants
took or on the length of time that they weretaking aspirin before
enrolling in the study. They looked onlyat current use, which
precludes a comparison of short term andlong term use. Also, the
homogeneity of the study populationpostmenopausalwomen, 98% of whom were whitemakes
it difficult to generalisetheresults.
ALL INFORMATION, DATA, AND
MATERIAL CONTAINED, PRESENTED, OR PROVIDED HERE IS FOR GENERAL INFORMATION
PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS REFLECTING THE KNOWLEDGE OR OPINIONS
OF THE PUBLISHER, AND IS NOT TO BE CONSTRUED OR INTENDED AS PROVIDING MEDICAL OR
LEGAL ADVICE. THE DECISION WHETHER OR NOT TO VACCINATE IS AN IMPORTANT AND
COMPLEX ISSUE AND SHOULD BE MADE BY YOU, AND YOU ALONE, IN CONSULTATION WITH
YOUR HEALTH CARE PROVIDER.
DISCLAIMER: All information, data, and material contained, presented, or provided here is for general information purposes only and is not to be construed as reflecting the knowledge or opinions of the publisher, and is not to be construed or intended as providing medical or legal advice. The decision whether or not to vaccinate is an important and complex issue and should be made by you, and you alone, in consultation with your health care provider.
Copyright 2013 by Vaccination News, A Non-Profit Corporation. All Rights Reserved. This content may not be copied unless permission in writing from Sandy Gottstein has been obtained.
"A foolish faith in authority is the worst enemy of truth."
-- Albert Einstein, letter to a friend, 1901
"I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education."
-- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820
"What's the point of vaccination if it doesn't protect you from the unvaccinated?"
-- Sandy Gottstein
"Who gets to decide what the greater good is and how many will be sacrificed to it?"