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Vaccine, Vol. 19 (25-26) (2001) pp. 3331 - 3346
© 2001 Elsevier Science Ltd. All rights reserved.
PII: S0264-410X(01)00028-7
WHO Collaborating
Centre for Neonatal Vaccinology, Departments of Pediatrics and Pathology,
University of Geneva, 1 Michel-Servet, 1211 Geneva 4, Switzerland
Received 20 September 2000; received
in revised form 27 December 2000; accepted 8 January 2001
Preclinical and human vaccine studies indicate that, although neonatal immunisation
does not generally lead to rapid and strong antibody responses, it may result
in an efficient immunological priming, which can serve as an excellent basis
for future responses. The apparent impairment of CD4 and CD8 T-cell function in
early life seems to result from suboptimal antigen-presenting cells-T cell
interactions, which can be overcome by use of specific adjuvants or delivery
systems. Although persistence of maternal antibodies may limit infant antibody
responses, induction of T-cell responses largely remain unaffected by these
passively transferred antibodies. Thus, neonatal priming and early boosting
with vaccine formulations optimised for sufficient early life immunogenicity
and maximal safety profiles, could allow better control of the huge infectious
disease burden in early life.
Keywords: Neonates; Infants; Vaccine responses;
Maternal antibodies
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