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August 16, 2001 Mystery DNA Is Discovered in Soybeans by Scientists
By ANDREW POLLACK
The mysterious DNA was found in the Monsanto Company's Roundup Ready
soybeans by Belgian government and university scientists, who described their
findings in a paper published yesterday in the journal European Food Research
and Technology. Greenpeace called yesterday for countries to re-evaluate the
regulatory approvals of the soybeans, saying that Monsanto did not know as
much as it should about its product. The unknown DNA could possibly affect
the safety of the beans, the group said. "I don't think you can come out and say it's unsafe," said Dr.
Janet Cotter-Howells, a scientist for Greenpeace in Britain. "You can
just say it's unknown whether it's unsafe or not." Monsanto acknowledged that the extra DNA was there, but it said it was
confident that the soybean was safe and that the unknown DNA had no effect on
the plant. Dr. Jerry J. Hjelle, the company's vice president for regulatory
affairs, said the DNA segment had been in the crop since the beginning as it
went through testing to prove its safety. Products made from Roundup Ready soybeans have been eaten by people and
animals for five years with no reports of health problems. Still, the
findings could cause some embarrassment for Monsanto and the agricultural
biotech industry because they raise questions about how well the molecular
makeup of the products is characterized. Roundup Ready soybeans contain a gene from a bacterium that allows the
plants to withstand Monsanto's Roundup herbicide. Farmers can thus spray
their fields with Roundup throughout the growing season to kill weeds without
harming the crop. More than half the soybeans grown in the United States are
now Roundup Ready. In Europe and Japan the beans are approved for use but not
for planting. This is the second time that scientists have found something in Roundup
Ready soybeans that Monsanto did not seem to know was there and had not cited
at the time of the product's approval. Last year the Belgian scientists and Monsanto, working independently,
found that the soybeans contained not only one complete copy of the bacterial
gene, as intended, but two fragments of that gene. Monsanto filed reports
with regulators around the world offering data to show that the fragments
were not active genes and had no effect on the plant. The paper now being published contains another revelation. Adjacent to one
of those gene fragments is another stretch of DNA that Monsanto, in its
report to regulators last year, had assumed was the soybean's native DNA. But the Belgian scientists, led by Dr. Marc De Loose of the Center for Agricultural
Research in Melle, said they could not find this stretch of DNA in the
soybean that had not been genetically engineered. They suggested that this unknown DNA is probably the plant's own DNA but
that it was somehow rearranged, or scrambled, at the time the bacterial gene
was inserted. Another possibility, they said, is that a portion of the
plant's DNA was deleted, leaving other DNA in that position. Dr. Hjelle, of Monsanto, said that the new paper by the Belgian scientists
had been available online for some time and that Monsanto had already
discussed the information with regulators. He said the unexpected DNA had
been found because more sensitive techniques had made it practical for the
first time to determine the sequence of the DNA flanking the inserted gene.
"As methods improve," he said, "we can find things from a
detailed perspective that we couldn't 10 years ago." Dr. Hjelle said the unknown sequence was only 534 letters long out of a
soybean genome of about 1.5 billion letters and was not meaningful. He also
said that the jumbling up of DNA near the spot where a new gene was inserted
was "expected by people who understand the science." Dr. David Ow, a senior scientist at the Department of Agriculture's Plant
Gene Expression Center in Albany, Calif., said that an inserted gene did not
always integrate itself into a plant in a neat way. "It's not so much that rearrangements occur, but what are the
consequences of it?" he said. Dr. Ow said he did not think that this
would pose a public safety issue, but he said it would pose a public
perception problem for the industry. "If one is submitting a product it has to be characterized to the
extent required by the regulatory bodies," he said. |
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