Decline in immunity to polio among young adults

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Vaccine, Vol. 19 (30) (2001) pp. 4162 - 4166
© 2001 Elsevier Science Ltd. All rights reserved.
PII: S0264-410X(01)00165-7

Decline in immunity to polio among young adults

Itamar Grotto a,b, Rachel Handsher c, Michael Gdalevich a,b, Daniel Mimouni a, Michael Huerta a, Manfred S. Green b,d, Ella Mendelson c and Ofer Shpilberg a,b * ofers@bgumail.bgu.ac.il

a Israel Defence Forces, Medical Corps, Military Post 02149, Israel
b Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
c Ministry of Health, Central Virology Laboratory, Tel-Hashomer, Israel
d Ministry of Health, The Israel Center for Disease Control (ICDC), Tel-Hashomer, Israel

Received 4 January 2001; received in revised form 29 March 2001; accepted 23 April 2001

Abstract

A serologic survey was conducted on a population-based representative sample of 521 18-year-old soldiers recruited to the Israel Defence Forces in 1997. The prevalence of neutralizing antibodies and geometric mean titers (GMTs) against the three types of poliovirus (Mahoney, MEF and Saukett strains) were found to be 98.7% (GMT --169.95), 99.6% (GMT --297.14) and 96.4% (GMT --59.48), respectively. These GMTs are markedly lower than those recorded 4 years after booster vaccination carried out during a 1988 polio outbreak, and suggest a decline in immunity against polio among young adults. These findings support the policy of routine revaccination of children and adolescents in countries at risk of imported polioviruses and of revaccination of adults traveling to areas to which polio is endemic.

Keywords: Poliovaccine; Antibodies; Immunity

*Corresponding author. Present address: Soroka University Medical Center, POB 151, Beer-Sheva 84101, Israel. Tel.: +972-8-6403325; fax: +972-8-6400195

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