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Vaccine-associated poliomyelitis in a child with sex-linked
agammaglobulinemia.
Wright PF, Hatch MH, Kasselberg AG, Lowry SP, Wadlington WB, Karzon DT.
Paralytic poliomyelitis was observed in a child with a sex-linked defect in
immunoglobulin synthesis. Evidence is presented that this was secondary to
administration of oral, live poliovaccine. The demonstration of a familial
sex-linked gammaglobulin deficiency and the failure to document a defect in
cell-mediated immunity in this child extends the risk of vaccine associated
poliomyelitis to virtually all forms of immunodeficiency.
The critical host factors in the
pathogenesis of poliovirus vaccine infection and in particular its unfavorable
outcome appear to include either a deficiency in the
humoral
(B cell) system or in the cell-mediated (T cell) system.
PMID: 197220 [PubMed - indexed for MEDLINE]
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