he
tale of Dr. Robert Gallo's role in the discovery of the virus that
causes AIDS is one of those stories that wouldn't be believable as
fiction. The narrative of John Crewdson's new book, "Science Fictions,"
is bursting with allegations leveled at Dr. Gallo, his associates,
rivals and enemies, that include deception, misconduct, incompetence,
fraud, sabotage, back-stabbing, double-dealing, overstatements,
half-truths, outright lies, a clandestine affair with a co-worker, a
bribery attempt, denials, evasions, coverups and serial rewritings of
history. All of this would be plausible in politics, but none of it is
the normal stuff of science.
Dr. Gallo, indeed, has steadfastly maintained his innocence of all
charges. As chief of the National Cancer Institute's Laboratory of Tumor
Cell Biology in Bethesda, Md., Dr. Gallo strode onto the world stage in
1983 and set into motion an amazing sequence of events. He had
identified a new virus from the blood of four AIDS patients, named it
HTLV (for human T-cell leukemia virus) and suggested that it was the
most likely cause of AIDS. But as later developments proved, it wasn't.
Meanwhile, at the Pasteur Institute in Paris, Luc Montagnier, the
chief of viral oncology, had isolated a genetically distinct virus from
a different batch of AIDS patients. Dr. Montagnier called the virus LAV
(lymphadenopathy-associated virus), and said that it was the cause of
AIDS. Later events proved he was right. (The virus was eventually
renamed H.I.V.)
In July 1983, before any of this was nailed down, Dr. Montagnier
personally delivered a sample of LAV to Dr. Gallo at his home in
Bethesda. Afterward, Dr. Gallo tossed off the incident as of virtually
no importance. "Was I so excited to get the thing?" he said. "No, I
really wasn't. I put it in my freezer and I went out and played
volleyball."
During the subsequent months, however, Dr. Gallo proceeded to
"discover" a new virus, one that he named HTLV-3B, and that he said was
the true cause of AIDS. It was, but his HTLV-3B was in fact LAV, and
although Dr. Gallo was passing it off as his own product, the virus,
according to Mr. Crewdson, had come directly from the French
researchers. "HTLV-3B and LAV weren't just the same kind of virus," he
writes. "They had come from the same patient."
Based on his "discovery," Dr. Gallo proposed a blood test for AIDS.
The test kits designed in response to his proposal were quickly approved
by the Food and Drug Administration, patented and rushed into production
by
Abbott Laboratories. In an early
field trial, however, the tests attained the notable distinction, Mr.
Crewdson says, of "an astounding false-positive rate of 99 in every
100," causing large amounts of good blood to be discarded, and leading
many people to falsely think they had AIDS.
A smaller number of false negatives caused some people to acquire
AIDS from transfusions of blood that they thought was safe. The Pentagon
needed an AIDS test for the armed services. Still, despite the abject
failure of the initial Gallo-designed test, the Pentagon refused to
consider the earlier French blood test for AIDS, which worked correctly,
on the ground that to do so would be un-American. The French finally
sued the United States Department of Health and Human Services for
violating a noncommercialization agreement, and, almost 10 years later,
won $6 million in royalties.
In 1992 a review panel of the National Academy of Sciences accused
Dr. Gallo of "intellectual recklessness of a high degree." That same
year, the Office of Research
Integrity of the National
Institutes of Health found him guilty of scientific misconduct. These
accusations and findings were later overturned on appeal.
Dr. Gallo, meanwhile, consistently denied wrongdoing. In response to
a Time magazine piece about the scientific-misconduct charges, he said:
"My colleagues and I isolated the AIDS virus in 1984. Actually, we made
many isolates (a total of 48) between 1983 and early 1984. This has been
acknowledged by everyone as has been the fact that it is my colleagues
and myself who showed that H.I.V. is the cause of AIDS and who also
developed the life-saving blood test which has protected our blood
supply since 1984."
Dr. Gallo, long immune to embarrassment over the accusations, had
acquired journalistic "groupies" who regularly touted him as a medical
wonder-worker. He won awards right and left, went on millionaire-style
vacations paid for by foreign universities and was pampered like
visiting royalty. "They treated me like a maharajah," Dr. Gallo said,
speaking of members of the Indian Oncological Society, who had brought
him to India. "They put garlands of flowers around my neck and sprinkled
me with oil. What a place."
Later, Dr. Gallo left the National Cancer Institute and became
director of the Institute of Human Virology at the University of
Maryland, Baltimore, where he remains today.
This summary, however, is only the bare outline of a story that
includes a vast array of characters, a bewildering variety of charges
and countercharges and an outsize share of plot convolutions. Mr.
Crewdson, the author of two previous books, is a reporter for The
Chicago
Tribune and a winner of
a Pulitzer Prize in 1981, when he reported for The New York Times. In
this book he explains the science clearly and carefully. Early on, the
lay reader will be able to confront a sentence like "Popovic
acknowledged growing LAV in Ti7.4 and one other cell line, though
without mentioning HUT-78 by name," and understand it perfectly the
first time through.
But at more than 500 pages of dense text, most of them packed with
equally arcane scientific information, it is all too easy to lose the
essential plotline in a sea of detail. The text is supplemented by a
5-page chronological summary of major events, a 13-page glossary of
technical terms and a 7-page list of dramatis personae, all of which
function as a life raft for the drowning reader.
Still, for all of its impressive depth, breadth and staggering
length, something important is missing from the book, namely a
documentation of its claims, or even so much as a bibliography. Instead,
the reader is glibly informed at the end: "The superscript numerals
appearing in the text indicate citational notes, which are available
online at www.sciencefictions.net." The story, in other words, is here,
but the evidence for it is elsewhere.
For a book that purports to be the canonical exposé of a shameful
episode in the history of science, this is a major lapse. It assumes,
for one thing, that anyone reading it, or at least anyone crazy enough
to care about proof, has convenient Internet access at every moment,
whether on vacation, or on a plane, a train or reading in bed. And it
assumes that the documentary Web site will exist indefinitely, or at
least for the lifetime of the book — all of which is highly dubious.
Indeed, the Web site could vanish tomorrow.
Let prospective purchasers be warned: if you buy a copy of "Science
Fictions," you will be paying the whole price, but you will not be
getting the whole book.
A publisher's dream method of cutting costs, perhaps: part book, part
e-book. One hopes it is not the start of a trend.
Ed Regis is the author of "The Biology of Doom: The History of
America's Secret Germ Warfare Project" and other books about science.