Department of Physiology, Emory University, Atlanta, Georgia
30322
Autism is a life-long developmental disorder affecting as manyas 1 in 500 children. The causes for this profound disorderare
largely unknown. Recent research has uncovered pathologyin the
gastrointestinal tract of autistic children. The pathology,reported
to extend from the esophagus to the colon, is describedhere along
with other studies pointing to a connection betweendiet and the
severity of symptoms expressed in autism. The evidencethat there is
impaired intestinal permeability in autism isreviewed, and various
theories are discussed by which a leakygut could develop. Lastly,
some possible ways in which impairedgastrointestinal function might
influence brain function arediscussed.
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