Safety and immunogenicity of hepatitis A vaccine in human immunodeficiency virus-infected patients: a double-blind, randomized, placebo-controlled trial.
Safety and immunogenicity of hepatitis A vaccine in human
immunodeficiency virus-infected patients: a double-blind, randomized,
placebo-controlled trial.
Kemper CA, Haubrich R, Frank I, Dubin G, Buscarino C, McCutchan JA,
Deresinski SC; California Collaborative Treatment Group.
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley
Medical Center, San Jose, California, USA. cakemper@earthlink.net
The safety and immunogenicity of inactivated hepatitis A (HepA) vaccine was
assessed in 133 hepatitis A virus-seronegative, human immunodeficiency virus
(HIV)-infected adults. Patients were randomly assigned to receive, in a blinded
fashion, either 2 doses of vaccine (1440 enzyme-linked immunosorbent assay
units) or placebo 6 months apart. Seroconversion at month 9 was observed in 68%
of those with CD4 cell counts >/=200 cells/mm(3) but in only 9% of those with
lower CD4 cell counts (P=.004). HepA vaccine was well tolerated and had no
effect on the course of HIV infection or plasma HIV RNA load.
DISCLAIMER: All
information, data, and material contained, presented, or provided here is for
general information purposes only and is not to be construed as reflecting the
knowledge or opinions of the publisher, and is not to be construed or intended
as providing medical or legal advice. The decision whether or not to vaccinate
is an important and complex issue and should be made by you, and you alone, in
consultation with your health care provider.
"A foolish faith in authority is the worst enemy of truth."
-- Albert Einstein, letter to a friend, 1901
"I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education."
-- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820
"What's the point of vaccination if it doesn't protect you from the unvaccinated?"
-- Sandy Gottstein
"Who gets to decide what the greater good is and how many will be sacrificed to it?"