May 23, 2003
DALLAS (American Heart Association)
-- A stroke that's deadly up to 50
percent of the time can be largely
prevented, according to a report in
the rapid access issue of Stroke:
Journal of the American Heart
Association.
The study indicates that
subarachnoid hemorrhage (SAH) is
largely preventable among younger
adult populations by using high blood
pressure drugs and with behavioral
changes such as quitting smoking and
cocaine use, says Joseph P. Broderick,
M.D., the study's lead author and a
professor of neurology at the
University of Cincinnati in Ohio.
"Our results should give people -
especially those with a family history
of bleeding stroke - even more impetus
to take better care of themselves," he
says.
Unlike other types of stroke that
occur more often in the elderly, SAH
often occurs in younger populations,
Broderick says. SAH occurs when a
blood vessel on the surface of the
brain ruptures and bleeds primarily
into the space surrounding the brain.
While SAH represents only about 3
percent of all strokes, it is among
the most deadly, with a 39 percent to
50 percent death rate.
To look at what might be causing
these strokes among young and
middle-aged adults, researchers
identified patients with SAH from 44
hospitals in Connecticut,
Massachusetts, Ohio, Kentucky, Rhode
Island and Texas between 1994 - 99.
The 312 patients participating in the
study were men and women between ages
18 and 49 with no prior stroke. They
answered questions about lifestyle and
other factors that could be related to
the development of SAH. Researchers
then compared the data from the stroke
patients with that of 618 matched
controls who had not had a stroke.
Researchers found notable
differences between the two groups.
"One of the study's key findings is
that two-thirds of the people who had
a subarachnoid hemorrhage in this age
group were current cigarette smokers.
That is a huge number," Broderick
says. "If you're a smoker in this age
group, you are about 3.7 times more
likely to have this type of stroke
than if you're not a smoker."
This is the first study to
scientifically prove that cocaine use
is associated with an increased risk
of subarachnoid hemorrhage, Broderick
says. While only 3 percent of people
with SAH reported recent cocaine use,
none of the people in the control
group reported using it.
High blood pressure is another
factor the study identified with
higher risk of SAH, highlighting the
importance of monitoring blood
pressure and controlling it if it's
high, Broderick says. Stroke patients
in the study were more than twice as
likely to have high blood pressure as
controls.
"There is also a familial tendency
for this type of stroke," he says.
People in the study who had SAH were
about 3.8 times more likely than
controls to have a family member who
had had bleeding stroke.
Researchers also found that,
compared with heavier people, those
with lower body mass index (relatively
thinner) were about 1.5 times more
likely to suffer a bleeding stroke.
"Quite frankly, we don't understand
that association very well," Broderick
says. "The other things that appeared
to increase stroke risk a little were
caffeine and nicotine in
pharmaceutical products. These may be
independent factors but need to be
explored more - the risk associations
are not as clear."