Clinical presentations and outcome of severe acute respiratory syndrome in children

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17 May 2003, Volume 361, Issue 9370 Pages 1701-1703
Clinical presentations and outcome of severe acute respiratory syndrome in children

KLE Hon a, C W Leung d, WTF Cheng a, PKS Chan b, WCW Chu c, Y W Kwan d, A M Li a, N C Fong d, P C Ng a, M C Chiu d, C K Li a, J S Tam b and T F Fok Send E-mail to Author a *

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Abstract
Hong Kong has been severely affected by severe acute respiratory syndrome (SARS). Contact in households and health-care settings is thought to be important for transmission, putting children at particular risk. Most data so far, however, have been for adults. We prospectively followed up the first ten children with SARS managed during the early phase of the epidemic in Hong Kong. All the children had been in close contact with infected adults. Persistent fever, cough, progressive radiographic changes of chest and lymphopenia were noted in all patients. The children were treated with high-dose ribavirin, oral prednisolone, or intravenous methylprednisolone, with no short-term adverse effects. Four teenagers required oxygen therapy and two needed assisted ventilation. None of the younger children required oxygen supplementation. Compared with adults and teenagers, SARS seems to have a less aggressive clinical course in younger children.


 

Affiliations
a Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China.
b Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China.
c Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China.
d Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong, China.

 * Correspondence to: Prof T F Fok, Department of Paediatrics, Chinese University of Hong Kong, 6/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, China 
 

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Elsevier Science Inc.

© 2003 Elsevier Science Ltd

 

 

 

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