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http://www.blackwell-synergy.com/links/doi/10.1046/j.1341-8076.2002.00076.x/abs/

Abstract
 
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The Journal of Obstetrics and Gynaecology Research

Volume 29 Issue 2 Page 84  - April 2003
 
Immunogenicity and safety of two schedules of Hepatitis B vaccination during pregnancy
Indu Gupta1 and Radha K. Ratho2
 
 Abstract

Aim: To test the immunogenicity and safety of Hepatitis B (HB) vaccination during pregnancy and passive transfer of antibodies to the newborn.

Methods: Ninety-nine HBsAg-negative pregnant women were divided randomly in two groups; group I was given two, and group II was given three doses of recombinant Hepatitis B vaccine and followed up until 4 months after delivery.

Results: The vaccination was safe. The maternal anti-HB antibody levels at delivery were significantly higher in three dose schedule as compared to two dose schedule. Similarly, the antibody levels in the newborns were higher in the three dose schedule. The maternal antibody levels were higher at 2 and 4 months post-delivery in group II but were observed to be declining in the newborns.

Conclusion: Hepatitis B vaccination during pregnancy is safe and highly immunogenic, and there is passive transfer of antibodies to the newborns.
 
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