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Pediatrics International
Volume 45 Issue 2 Page 223 - April 2003
1 (TSST1) and staphylococcal enterotoxin C
(SEC). These predominant MRSA strains belong to coagulase type II,
SCCmec type II, mecA-Tn554 polymorph type I-A
and show closely related pulse field gel electrophoresis types. The
dissemination of MRSA is wide, and there is a pandemic distribution
of a single MRSA clone in the NICU of Japan. Since 1992, the
nationwide spread of this clone has also led to the development of a
new neonatal disease known as neonatal toxic shock-like
exanthematous disease (NTED), which is caused by overactivation of v
2+ T cells induced by TSST1.The spread of MRSA in NICU in Japan has been attributed to overcrowding, high rates of extremely low birthweight babies, understaffing, low control measures of infection and overuse of antibiotics. The environment of NICU and infection control intervention should be improved and a new strategy for control like vaccination or probiotics is required.
