Genetics
Autism is
'two separate illnesses'
Robin McKie,
science editor
Sunday March 16, 2003
The Observer
Autism, the devastating mental illness that affects thousands of UK
children every year, is not a single psychological condition,
scientists have discovered.
Researchers have found the ailment is really a combination of two
separate illnesses, each controlled by different sets of genes.
The discovery, outlined yesterday at the British Psychological
Society conference, is expected to cause intense interest among
psychologists. Many believe prospects of uncovering the condition's
genetic causes and finding new treatments have been significantly
boosted.
'In effect, we're saying there is no such thing as autism, but
two separate conditions which - if they occur at the same time in
the same child - give rise to symptoms that we associate with
autistic individuals,' said Professor Robert Plomin, of the
Institute of Psychiatry, London. 'That has tremendous implications
for helping these children.'
Autism sufferers display rigid, obsessive behaviour and largely
lack an ability to relate to family members. More worryingly,
numbers of cases have been rising rapidly in recent years - with
more than 2,000 children being diagnosed in Britain every year.
Scientists are still unsure why this rise is occurring, however.
Typically sufferers - who start to display symptoms around the
age of two or three - are compulsive, withdrawn and have explosive
outbursts.
'Diagnoses depend on two observations,' said Dr Angelica Ronald,
of the Institute of Psychiatry. 'First, the social component:
autistic children do not understand that other people have minds of
their own. They are tactless and uncommunicative. Second, there is
the non-social aspect. Children are obsessive about objects and
pre-occupied with details of places or events.'
In the past, psychologists assumed these two sets of symptoms had
the same cause. But a major study led by Ronald and Plomin of 4,000
pairs of twins has found this to be incorrect. Autism's two sets of
symptoms are actually acquired quite separately.
'The two sets of symptoms are associated with two completely
different sets of genes,' Ronald said. 'Only when a person inherits
extreme versions of both do they exhibit the symptoms of full
autism.'
We have not been able to pinpoint these genes,' Plomin said. 'Now
we know why. We have been looking at two conditions, not one.'
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