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Experimental Gerontology
Volume 38, Issue 5 , May 2003, Pages 583-587
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doi:10.1016/S0531-5565(03)00062-7
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Copyright © 2003 Elsevier Science Inc. All rights reserved.
Association of increased neopterin production with decreased humoral immunity in the elderly
Christian Murra, Ursula Hainzb,
Ester Aschb, Peter Bergerb,
Brigitte Jeneweinb, Maria Saurwein-Teisslb, Beatrix Grubeck-Loebensteinb
and Dietmar Fuchs
,
, a,
c
Tetanus toxoid (TT) antibodies of 447 adult persons aged 27–69 years
were investigated and analyzed in relationship with the time span since
the last vaccination against tetanus as well as the serum concentration of
neopterin. Neopterin is a pteridine, which is produced by
monocytes/macrophages upon stimulation with the type 1 T cell-derived
cytokine interferon-
. There was an inverse correlation
between serum neopterin and TT antibody concentrations (Spearman's rank
correlation coefficient: rs=-0.259; p<0.0001)
which was even stronger when persons with neopterin concentrations and TT
antibodies below the third quartile of the study population were excluded
(residual group: n=210; rs=-0.718; p<0.0001).
The study demonstrates that an immunoregulatory shift towards type 1 immunity as indicated by higher neopterin concentrations coincides with lower TT antibody concentrations in the elderly.
Author Keywords: Tetanus toxoid antibodies; Neopterin;
Aging
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