Association of increased neopterin production with decreased humoral immunity in the elderly

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Experimental Gerontology
Volume 38, Issue 5 , May 2003, Pages 583-587


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doi:10.1016/S0531-5565(03)00062-7    How to cite or link using doi (opens new window) Cite or link using doi  
Copyright © 2003 Elsevier Science Inc. All rights reserved.

 

Association of increased neopterin production with decreased humoral immunity in the elderly

 

Christian Murra, Ursula Hainzb, Ester Aschb, Peter Bergerb, Brigitte Jeneweinb, Maria Saurwein-Teisslb, Beatrix Grubeck-Loebensteinb and Dietmar FuchsCorresponding Author Contact Information, E-mail The Corresponding Author, a, c

a Institute of Medical Chemistry and Biochemistry, Leopold-Franzens University, Innsbruck, Austria
b Institute for Biomedical Aging Research of the Austrian Academy of Science, Innsbruck, Austria
c Ludwig Boltzmann Institute of AIDS-Research, Innsbruck, Austria

Received 26 July 2002;  revised 23 December 2002;  accepted 17 February 2003. ; Available online 16 March 2003.


 

Abstract

Tetanus toxoid (TT) antibodies of 447 adult persons aged 27–69 years were investigated and analyzed in relationship with the time span since the last vaccination against tetanus as well as the serum concentration of neopterin. Neopterin is a pteridine, which is produced by monocytes/macrophages upon stimulation with the type 1 T cell-derived cytokine interferon-small gamma, Greek. There was an inverse correlation between serum neopterin and TT antibody concentrations (Spearman's rank correlation coefficient: rs=-0.259; p<0.0001) which was even stronger when persons with neopterin concentrations and TT antibodies below the third quartile of the study population were excluded (residual group: n=210; rs=-0.718; p<0.0001).

The study demonstrates that an immunoregulatory shift towards type 1 immunity as indicated by higher neopterin concentrations coincides with lower TT antibody concentrations in the elderly.

Author Keywords: Tetanus toxoid antibodies; Neopterin; Aging


 

Corresponding Author Contact InformationCorresponding author. Address: Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, A-6020 Innsbruck, Austria. Tel.: +43-512-507-3519; fax: +43-512-507-2865



 
 
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Experimental Gerontology
Volume 38, Issue 5 , May 2003 , Pages 583-587


 

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