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3 May 2003, Volume 361, Issue 9368 Pages 1521-1523
Risk of vaccine failure after Haemophilus influenzae type b (Hib) combination vaccines with acellular pertussis

J McVernon Send E-mail to Author a,b *, N Andrews a, MPE Slack c and M E Ramsay a
 
Abstract
An increase in invasive Hib disease incidence in the UK has coincided with the distribution of combination vaccines that contain acellular pertussis (DTaP-Hib). These vaccines have been associated with reduced immunogenicity of the Hib component, although there is little agreement on the clinical relevance of this finding. We retrospectively compared vaccine formulations given to fully vaccinated Hib cases with those administered to fully immunised age-matched controls using conditional logistic regression. More cases than controls received all three doses of their infant primary course as DTaP-Hib, compared with two or three doses of another Hib vaccine (conditional odds ratio 6·77 [95% CI 3·26–14·07]).

Affiliations
a Immunisation Division, Health Protection Agency Communicable Disease Surveillance Centre, Colindale, London, UK.
b Oxford Vaccine Group, University of Oxford Department of Paediatrics, Oxford, UK.
c Health Protection Agency Haemophilus Reference Unit, Oxford, UK.

 * Correspondence to: Dr Jodie McVernon, Immunisation Division, Health Protection Agency, Communicable Disease Surveillance Centre, London NW9 5EQ, UK 

 

Source

Elsevier Science Inc.

© 2003 Elsevier Science Ltd

 

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