Haemophilus influenzae type b vaccine formulation and risk of childhood leukaemia

> Haemophilus influenzae type b vaccine formulation and risk of childhood leukaemia

   

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http://www.nature.com/cgi-taf/DynaPage.taf?file=/bjc/journal/v87/n5/abs/6600489a.html

27 August 2002, Volume 87, Number 5, Pages 511-512
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Epidemiology
Haemophilus influenzae type b vaccine formulation and risk of childhood leukaemia
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F Groves1, D Sinha1 and A Auvinen2,3
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1Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, SC 29425-0835, USA

2Finnish Cancer Registry, Liisankatu 21 B, FIN-00170 Helsinki, Finland

3School of Public Health, University of Tampere, FIN-33014 Tampere, Finland
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Correspondence to: F Groves, Department of Biometry and Epidemiology, Medical University of South Carolina, 135 Cannon Street, Room 302-H, Charleston, SC 29425-0835, USA; E-mail: grovesf@musc.edu
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Abstract
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Incidence of childhood leukaemia was studied among subjects of a vaccine trial in Finland comparing the polysaccharide-diptheria toxoid conjugate and oligosaccharide-CRM197 conjugate Haemophilus influenzae type b conjugate vaccine formulations. Eighty cases of childhood leukaemia were detected: 35 among children on the polysaccharide-diptheria toxoid conjugate arm, and 45 among children on the oligosaccharide-CRM197 conjugate arm, which was not statistically significant.

British Journal of Cancer (2002) 87, 511-512. doi:10.1038/sj.bjc.6600489

www.bjcancer.com

 

Ó 2002 Cancer Research UK
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Keywords
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leukaemia; child; vaccinations; Haemophilus influenzae type b; clinical trials
 
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Received 3 April 2002; revised 3 May 2002; accepted 5 June 2002
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27 August 2002, Volume 87, Number 5, Pages 511-512
 
© 2002 Cancer Research UK

 

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