Elevated levels of measles antibodies in children with autism

> Elevated levels of measles antibodies in children with autism

   

Return to Vaccination News Home Page  __»   Right-click to "open in new window"

Subscribe to the Vaccination NewsLetter

View past & current Scandals (columns by Sandy Mintz)

Search This Site using keywords

 

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TBD-481FFJP-3&_user=1940244&_handle=W-WA-A-A-DW-MsSAYVA-UUA-AUCZVVWUWA-AAWEDVBCU-DW-U&_fmt=summary&_coverDate=02%2F27%2F2003&_rdoc=51&_orig=browse&_srch=%23toc%235140%239999%23999999999%2399999!&_cdi=5140&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=1940244&md5=f765897a42a589a5efa9d1a803d03145

 

 

Go to ScienceDirect® Home Skip Main Navigation Links

 Register or Login: 

 Password:

 

  Athens Login 

HomeBrowse JournalsBrowse Abstract DatabasesBrowse Reference WorksMy AlertsMy Profile

Help (Opens new window)

1 of 1

Result ListNo Previous DocumentNo Next Document

Pediatric Neurology
Volume 28, Issue 4 , April 2003, Pages 292-294


 

This Document

 

Abstract

 

Full Text + Links

 

PDF (83 K)

 

 

Actions

 

E-mail Article

 


doi:10.1016/S0887-8994(02)00627-6    How to cite or link using doi (opens new window) Cite or link using doi  
Copyright © 2003 Elsevier Science Inc. All rights reserved.

Original article

 

Elevated levels of measles antibodies in children with autism

 

Vijendra K. Singh PhD*, Corresponding Author Contact Information and Ryan L. Jensen BS

* Department of Biology and Biotechnology Center, Utah State University, Logan, Utah, USA

Received 23 July 2002;  accepted 28 October 2002. ; Available online 27 February 2003.


 

Abstract

Virus-induced autoimmunity may play a causal role in autism. To examine the etiologic link of viruses in this brain disorder, we conducted a serologic study of measles virus, mumps virus, and rubella virus. Viral antibodies were measured by enzyme-linked immunosorbent assay in the serum of autistic children, normal children, and siblings of autistic children. The level of measles antibody, but not mumps or rubella antibodies, was significantly higher in autistic children as compared with normal children (P = 0.003) or siblings of autistic children (P less-than or equal to 0.0001). Furthermore, immunoblotting of measles vaccine virus revealed that the antibody was directed against a protein of approximately 74 kd molecular weight. The antibody to this antigen was found in 83% of autistic children but not in normal children or siblings of autistic children. Thus autistic children have a hyperimmune response to measles virus, which in the absence of a wild type of measles infection might be a sign of an abnormal immune reaction to the vaccine strain or virus reactivation.

Author Keywords: Autism; measles virus; vaccine; viral antibodies; mumps virus; rubella virus


 

Corresponding Author Contact InformationCorresponding author. Communications should be addressed to: Dr. Singh; Biotechnology Center; Utah State University; 4700 Old Main Hill; , Logan, Utah, 84322, , USA.



 
 
  This Document
  Abstract
  Full Text + Links
  PDF (83 K)
 
  Actions
  E-mail Article
 

Pediatric Neurology
Volume 28, Issue 4 , April 2003 , Pages 292-294



 

1 of 1 Result ListNo Previous DocumentNo Next Document
HomeBrowse JournalsBrowse Abstract DatabasesBrowse Reference WorksMy AlertsMy Profile   Help (Opens new window)


 

Send feedback to ScienceDirect
Software and compilation © 2003 ScienceDirect. All rights reserved.
ScienceDirect® is an Elsevier Science B.V. registered trademark.


Your use of this service is governed by Terms and Conditions. Please review our Privacy Policy for details on how we protect information that you supply.

 

Return to Vaccination News Home Page  __»   Right-click to "open in new window"

DISCLAIMER:    All information, data, and material contained, presented, or provided here is for general information purposes only and is not to be construed as reflecting the knowledge or opinions of the publisher, and is not to be construed or intended as providing medical or legal advice.  The decision whether or not to vaccinate is an important and complex issue and should be made by you, and you alone, in consultation with your health care provider.