Weaning preterm infants: a randomised controlled trial
L D Marriott1, K D Foote2,
J A Bishop1, A C Kimber3 and
J B Morgan1
1 School of Biomedical and Life Sciences,
University of Surrey, Guildford, Surrey GU2 7XH, UK 2 Department Paediatrics and Child Health, Royal Hampshire County
Hospital, Winchester, Hampshire SO22 5DG, UK 3 School of Applied Statistics, University of Reading, PO Box 240,
Reading, Berkshire RG6 6FN, UK
Dr Marriott, Medical Research Council Environmental Epidemiology Unit, Tremona
Rd, Southampton SO16 6YD, UK; email@example.com
Objective: To assess the effect on growth and iron status inpreterm infants of a specially devised weaning strategy comparedwith current best practices in infant feeding. The preterm weaningstrategy recommended the early onset of weaning and the useof
foods with a higher energy and protein content than standardmilk
formula, and foods that are rich sources of iron and zinc.
Subjects and design: In a blinded, controlled study, 68 preterminfants (mean (SD) birth weight 1470 (430) g and mean (SD) gestationalage 31.3 (2.9) weeks) were randomised to either the preterm
weaning strategy group (n = 37) or a current best practice control
group (n = 31), from hospital discharge until 1 year gestation
corrected age (GCA).
Main outcome measures: Weight, supine length, occipitofrontalhead circumference, and intakes of energy, protein, and mineralswere determined at 0, 6, and 12 months GCA. Levels of haemoglobin,serum iron, and serum ferritin were assayed at 0 and 6 months
Results: Significant positive effects of treatment included:greater increase in standard deviation length scores and length
growth velocity; increased intake of energy, protein, and carbohydrateat 6 months GCA and iron at 12 months GCA; increased haemoglobinand serum iron levels at 6 months GCA.
Conclusions: The preterm weaning strategy significantly influenceddietary intakes with consequent beneficial effects on growthin
length and iron status. This strategy should be adopted asthe basis
of feeding guidelines for preterm infants after hospitaldischarge.
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whether or not to vaccinate is an important and complex issue and should
be made by you, and you alone, in consultation with your health care
DISCLAIMER: All information, data, and material contained, presented, or provided here is for general information purposes only and is not to be construed as reflecting the knowledge or opinions of the publisher, and is not to be construed or intended as providing medical or legal advice. The decision whether or not to vaccinate is an important and complex issue and should be made by you, and you alone, in consultation with your health care provider.
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