BOSTON, Massachusetts (AP) --An absorbing book or a challenging crossword puzzle
may keep your mind more than busy. It may keep it healthy, too, according to a
21-year study of mental breakdown in old age.
The study adds to the evidence that stimulating the mind can ward off
Alzheimer's disease and other dementia, much as physical exercise can keep the
body fit.
The study was led by Albert Einstein College of Medicine in New York City and
published in Thursday's New England Journal of Medicine. It was funded by the
National Institute on Aging.
Researchers are eager to establish whether keeping mentally active can help
guard against dementia. That would provide a simple, drug-free way of reducing
the risk of the widespread, debilitating ailment. About 10 percent of people
develop dementia between ages 60 and 70.
"I think the hypothesis is plausible enough that I spent several years of my
life trying to figure out what the mechanism is, and I would advise our
government to spend millions of dollars trying to figure it out," said Dr. David
Bennett, a neurologist at Rush-Presbyterian-St. Luke's Hospital in Chicago. He
has done similar research.
In the Einstein College study of 469 elderly people, those in the top third
in mental activity had a 63 percent lower risk of dementia than the bottom
third. Taking part in a single activity one day a week reduced the risk by 7
percent.
The use-it-or-lose-it notion is not a new idea. Other researchers have
discovered evidence that mental activity may guard against dementia. But it is
hard to prove, since early dementia without obvious symptoms may cause people to
slack off their hobbies. If this is so, dementia affects hobbies -- and maybe
not the reverse.
The researchers tried to minimize that possibility by considering only those
who were dementia-free for seven years after joining the study. They also tried
to eliminate the potential role of education and intelligence in guarding
against dementia.
This study also took physical exercise into account. Nearly all physical
activities, including stair climbing and group exercise, appeared to offer no
protection against dementia. The only exception was frequent dancing, perhaps
because dance music engages the dancer's mind, suggested lead researcher Joe
Verghese, a neurologist at Einstein College.
It is not clear what physiological mechanism might confer the protection. But
researchers say evidence is accumulating that the brain is much more easily
molded than scientists once thought. Mentally engaging hobbies might lay down
new neural pathways, one theory holds.
"The cerebral cortex and hippocampus, which are critical to these activities,
are remarkably plastic, and they rewire themselves based upon their use," said
Dr. Joseph Coyle, a Harvard Medical School psychiatrist who wrote an
accompanying commentary.
Even if keeping the mind busy offers no protection against dementia, Verghese
said doctors can hardly go wrong in recommending it: "If nothing else, it
improves the quality of life."
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