Developmental factors associated with risk for atopic disease: implications for vaccine strategies in early childhood

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doi:10.1016/S0264-410X(03)00345-1    How to cite or link using doi (opens new window) Cite or link using doi  
Copyright © 2003 Published by Elsevier Science Ltd.

 

Developmental factors associated with risk for atopic disease: implications for vaccine strategies in early childhood

 

P. G. HoltCorresponding Author Contact Information, E-mail The Corresponding Author, a, J. Rowea, R. Lohb and P. D. Slya

a Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, P.O. Box 855, Perth, WA 6872, Australia
b Princess Margaret Hospital for Children, Perth, WA 6872, Australia

Received 8 December 2002;  accepted 25 March 2003. ; Available online 14 May 2003.
 

Abstract

There is growing interest in the potential interactions between infant vaccination and risk for development of atopic disease. The aspect of this issue which has dominated this debate concerns suggestions that infant vaccination may stimulate allergic sensitisation. These suggestions derive from retrospective epidemiological analyses and will remain speculative unless they can be confirmed in prospective studies, particularly as conflicting findings have been reported. However, there is a potentially more important issue surfacing in this debate, which entails the converse situation, i.e. that genetic risk for atopy influences capacity to respond to vaccination during infancy. Support for the latter possibility comes from recent studies on the role of developmental factors which determine immune competence during infancy, and attendant risk for inflammatory and infectious diseases. The relevant findings are reviewed briefly below.

Author Keywords: Atopic disease; Vaccination; Developmental factors

 

Corresponding Author Contact InformationCorresponding author. Tel.: +61-8-9489-7838; fax: +61-8-9489-7707.

 

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