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http://news.ninemsn.com.au/nnhwatch/story_49229.asp

Wed 4 Jun 2003

Australian HIV vaccine trial underway

The first clinical trial of a new HIV vaccine, developed entirely in Australia, has begun recruiting volunteers. The trial, which will focus on establishing the safety of the vaccine, will take place at St Vincent's Hospital in Sydney. Australian researchers say the vaccine is a new way of boosting the immune system, which may help the body fight off HIV.

Aids now affects a staggering 40 million people around the world. Experts warn explosive epidemics are expected in our region, and with 16,000 new cases reported globally every day, a preventative vaccine is a top priority.

One recently trialled in Asia failed but today Australian researchers announced they believe they have the answer.

"It's now become clear that a different type of immune response, called a killer immune cell, is going to be required to control HIV," said Associate Professor Stephen Kent.

Their solution is a double-whammy vaccine. "First you have to prime the immune system with one vaccine, then come back and boost it with a separate vaccine," Associate Professor Kent said.

Tests on animals were so effective, the Australian team — involving three universities, the CSIRO and Sydney's St Vincent's Hospital — has been selected and given the largest ever foreign grant, from the United States Government, to move into human trials.

Combining this double action in a vaccine is a world first and the researchers are keen to test its effectiveness. But they stress this first trial is about safety and only when they can establish there are no serious side-effects in humans will they go on to large scale prevention trials in Thailand.

Twenty-four healthy volunteers are needed at St Vincent's Hospital to see if the vaccine safely boosts their immune system. The volunteers will have a series of shots, and be closely monitored. Results are expected at the end of the year.

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