PEDIATRICS Vol. 111 No. 6 June 2003, pp. 1358-1366
Patient Safety Events During Pediatric
Hospitalizations
Marlene R. Miller, MD, MSc*,, Anne Elixhauser, PhD
and Chunliu Zhan, MD, PhD*
* Center for Quality Improvement and Patient Safety
Center for Organization and Delivery Studies, Agency for Healthcare Research and
Quality, Rockville, Maryland
Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland
Objective. Our objective was to describe potential patient
safetyevents for hospitalized children, using the patient safety
indicators(PSIs), and examine associations with these events.
Methods. PSI algorithms, developed by researchers at the Agencyfor Healthcare Research and Quality to identify potential in-hospitalpatient safety problems using administrative data, were applied
to 3.8 million discharge records for children under 19 yearsfrom 22
states in the 1997 Healthcare Cost and Utilization Project.
Prevalence of PSI events and associations with patient-leveland
hospital-level characteristics, length of stay, in-hospital
mortality, and total charges were examined.
Results. The prevalence of pediatric patient safety events issignificant with the highest rate found for birth trauma at1.5
cases per every 100 births. The majority of these eventsfor birth
trauma consist of long bone and skull fractures, excludingthe
clavicle. Compared with records without PSI events, dischargeswith
PSI events had 2- to 6-fold longer lengths of stay, 2-to 18-fold
higher rates of in-hospital mortality, and 2- to20-fold higher total
charges. Bivariate and multivariate analysesfound that all PSI
events except birth trauma were directlyassociated with factors
related to greater severity of illnessand large urban teaching
institutions. Birth trauma, however,was directly associated with
black and Hispanic ethnicity butwas not consistently associated with
technologically sophisticatedteaching institutions.
Conclusions. The prevalence of birth trauma and other potentialpatient safety events for hospitalized children is high and
comparable to hospitalized adults. These events are associatedwith
increased length of stay, in-hospital mortality, and totalcharges.
Associated factors differ significantly for birth traumacompared
with other PSI events. Institutional application ofthe PSIs may be
useful to identify processes of care that warrantfurther evaluation
as the health care industry tackles the problemof patient safety,
particularly for children.
Abbreviations: PSI, patient safety indicator IOM,
Institute of Medicine AHRQ, Agency for Healthcare Research and Quality
ICD-9-CM, International Classification of Diseases, Ninth
Revision, Clinical Modification APR-DRG, All-Patient Refined-Diagnosis
Related Group COTH, Council of Teaching Hospital CI, confidence interval
OR, odds ratio
Received for publication Jun 12, 2002; accepted Nov 22, 2002.
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