Approximately 2 million people in the United States have epilepsy, a chronic
disorder of the brain that causes a tendency to have recurrent seizures. Two or
more seizures must occur before a person can receive the diagnosis of epilepsy,
also known as a seizure disorder. It's not uncommon for children to have a
single seizure, and an estimated 5 percent to 10 percent of the population will
experience a seizure at some time in their life.
Seizures occur when there's a sudden change in the normal way your brain
cells communicate through electrical signals. During a seizure, some brain cells
send abnormal signals, which stop other cells from working properly. This
abnormality may cause temporary changes in sensation, behavior, movement or
consciousness.
The onset of epilepsy is most common during childhood and after age 65, but
the condition can occur at any age. Treatments may be able to leave you free of
seizures, or at least reduce their frequency and intensity.
Because abnormal brain cell activity causes seizures, having a seizure can
result in the sudden occurrence of any activity that's coordinated by your
brain. This can include slight temporary confusion, complete loss of
consciousness, a staring spell, muscle spasms, or uncontrollable, jerking
movements of the arms and legs. Seizures originating in your brain's temporal
lobe can be associated with a sense of deja vu, anxiety and panic, or simply an
uneasy sensation in your stomach, which can be followed by loss of
consciousness.
Signs and symptoms may vary depending on the type of seizure. Most people
with epilepsy experience the same type of seizure, with similar symptoms, each
time they have a seizure, but others may experience a wide range of types and
symptoms.
Doctors classify seizures as either partial or generalized, based on how the
abnormal brain activity begins. When seizures appear to result from abnormal
activity in just one part of the brain, they're called partial seizures. When
seizures seem to involve most or all of the brain, the seizures are called
generalized.
Both classifications are broken up further into smaller, more specific
categories:
Partial seizures are separated into simple
partial, complex partial and secondary generalized seizures.
Primary generalized seizures are separated into
absence (petit mal), myoclonic, atonic and generalized tonic-clonic (grand
mal) seizures.
Partial seizures
Some people experience a warning sensation, called an aura, before one of
the following types of partial seizure begins:
Simple partial seizures.
These seizures begin
from a small area in your brain and don't result in loss of consciousness.
They may cause uncontrolled shaking of an arm, leg, or any other part of
your body; alter emotions; change the way things look, smell, feel, taste,
or sound; or cause speech disturbance.
Complex partial seizures. These seizures also
begin from a small area of your brain. They alter consciousness and
usually cause memory loss (amnesia). They can cause staring and
nonpurposeful movements, such as repeated hand rubbing, lip smacking,
posturing of your arm, vocalization or swallowing. After the seizure ends,
you may be confused or sleep for a few minutes and may be unaware you had
the seizure. Temporal lobe seizures are the most common type of complex
partial seizures.
Secondary generalized seizures (partial seizures
with secondary generalization). These seizures occur when simple or
complex seizures spread to involve your entire brain. They may begin as a
complex partial seizure with staring and nonpurposeful movements. The
seizure then becomes more intense, leading to generalized convulsions
characterized by stiffening and shaking of your extremities and your body.
Generalized seizures
Absence (petit mal seizures). These seizures
are characterized by staring, subtle body movement and brief lapses of
awareness. They're usually brief, and typically no confusion or sleepiness
occurs when the seizure is over.
Myoclonic seizures. These seizures usually
appear as sudden jerks of your arms and legs. They typically affect only
one side of your body, but may affect both sides. Myoclonic seizures may
last only a short time from less than a second for single jerks to a few
seconds for repeated jerks.
Atonic seizures. Also known as drop attacks,
these seizures cause you to suddenly collapse or fall down. After a few
seconds, you regain consciousness and are able to stand and walk.
Generalized tonic-clonic (grand mal seizures).
The most intense of all types of seizures, these are characterized by a
loss of consciousness, body stiffening and shaking, and sometimes tongue
biting or loss of bladder control. After the shaking subsides, a period of
confusion or sleepiness usually occurs, lasting for a few minutes to a few
hours.
The onset of epilepsy can often be traced to an accident, disease or medical
trauma such as a stroke that injures your brain or deprives it of oxygen,
often causing a small scar in your brain. In rare occasions, epilepsy may be
caused by a tumor in your brain. However, in many cases there's no identifiable
cause for the disease.
Epilepsy isn't a mental disease, although mental health can influence the
control of seizures in epilepsy. Epilepsy doesn't cause psychiatric problems or
mental retardation, but people with epilepsy may also be afflicted with those
conditions.
Research suggests that genetic abnormalities contribute significantly to
epilepsy. If you have a family history of the disease, you may be at increased
risk.
Head injuries are responsible for many cases of epilepsy. You can reduce your
risk by always wearing a seat belt while riding in a car and by wearing a helmet
while bicycling, skiing, riding a motorcycle, or engaging in other activities
with a high risk of head injury.
Stroke and other diseases that affect your vascular system can lead to brain
damage that may trigger epilepsy. You can take a number of steps to reduce your
risk of these diseases, including limiting your intake of alcohol, following a
healthy diet, managing your weight, exercising regularly and avoiding
cigarettes.
Other epilepsy risk factors include:
Alzheimer's disease
Brain infections
Poisoning from exposure to lead, carbon monoxide and other toxins
Having a known diagnosis of epilepsy may not mean you need to seek medical
help each time you have a seizure, as long as you're well versed in what to do
when a seizure occurs. Seek medical advice if you experience a seizure for the
first time. Also, seek medical help if any of the following occur:
The seizure lasts more than five minutes
Recovery from your seizure is slow
A second seizure follows immediately
You're pregnant or have diabetes
Signs of injury or illness are present
Your seizures change in frequency and severity
There's a change in the way you feel during and after the seizures
occur
Your seizure is preceded by a sudden, severe headache or other signs
and symptoms of stroke, including weakness or numbness on one side of your
body, vision loss, confusion, coordination or speech problems
You change your seizure medication or begin taking other medicines
If you see someone having a seizure, call for medical help immediately and
then follow these tips:
Gently roll the person onto one side and put
something soft under his or her head.
Loosen tight neckwear.
Don't try to put your fingers or anything else in
the person's mouth. The tongue can't be swallowed.
Don't try to restrain the person.
Look for a medical alert bracelet. The bracelet
should state who to contact in an emergency and what medications the
person uses. Allergies to medications may be noted.
Stay with the person until medical personnel
arrive. If possible, observe the person closely so that you can provide
details on his or her signs and symptoms and how long the seizure lasted.
Screening and diagnosis
Because the possible causes of seizures are many, doctors may need to ask
detailed questions and perform several tests to diagnose epilepsy, including:
Medical history.
Descriptions of your past
seizures from yourself or others who have observed your seizures may
help your doctor identify the type and cause of your problem. Your
physician may also need to know about your current and past medical
conditions and how they've been treated.
Physical and neurologic examination. A
neurologic examination may include testing your reflexes, muscle tone and
strength, the function of your senses, and your gait, posture,
coordination and balance. Your doctor may also ask questions to test your
thinking, judgment and memory.
Blood tests. Your doctor may want to take
samples of your blood to be tested for chemical imbalances that may be the
cause of your seizures.
Electroencephalogram (EEG). This procedure
records the electrical activity of your brain. An EEG helps determine what
type of seizures or epilepsy you have and from which part of the brain
seizures may start. During the procedure, which takes about a half-hour,
you lie down. Between 16 and 30 small electrodes may be attached to your
scalp with paste or an elastic cap. You remain still during the test, but
at times you may be asked to breathe deeply and steadily for several
minutes or to stare at a patterned board. At times a light may be flashed
in your eyes. These actions are intended to stimulate your brain in ways
that might be seen on the EEG. The electrodes pick up the electrical
impulses from your brain and send them to the EEG machine, which records
your brain waves on a moving sheet of paper or digitally on a computer
screen.
Computerized tomography (CT). A CT scan
produces detailed cross-sectional images of your brain. The images may
reveal abnormalities in brain structure, including tumors, cysts, strokes
or tangled blood vessels.
Magnetic resonance imaging (MRI). An MRI scan
uses a powerful magnetic field and radio waves to produce images of your
brain. Like CT scans, MRI images may reveal abnormalities in brain
structure.
Recurrent seizures may put you and others at risk of physical harm. Seizures
may produce injuries associated with falling, such as a head injury. A seizure
that occurs while swimming could cause you to drown.
A seizure that causes either loss of awareness or control can be dangerous if
you're driving a car or operating other equipment. Drugs used to control
seizures also can affect your driving ability. Many states have licensing
restrictions related to your ability to control seizures.
Life-threatening complications from epilepsy are uncommon, but do occur.
People who have prolonged or continuous seizures (status epilepticus) are at
increased risk of permanent brain damage and death.
Treatment
Medications
Most people with epilepsy can become free of their seizures by using a
single antiepileptic drug. For others, medication can make seizures less
frequent and less intense. More than half of children with epilepsy whose
seizures are controlled by medications can eventually stop their medications and
live a seizure-free life. Many adults also can discontinue medication after two
or more years without seizures.
Finding the right medication and dosage can be complex. It might take more
than one drug, or trying several different drugs until the right one is found.
Medications available for the treatment of seizures include phenytoin (Dilantin,
Phenytek), carbamazepine (Carbatrol, Tegretol), valproic acid (Depakene),
divalproex (Depakote), levetiracetam (Keppra), gabapentin (Neurontin),
phenobarbital, ethosuximide (Zarontin), clonazepam (Klonopin), lorazepam
(Ativan, Lorazepam Intensol), diazepam (Diastat, Valium), primidone (Mysoline),
oxcarbazepine (Trileptal), lamotrigine (Lamictal), topiramate (Topamax),
felbamate (Felbatol), tiagabine (Gabitril) and zonisamide (Zonegran).
All of these medications have some side effects, which may include mild
fatigue, dizziness and weight gain. More severe side effects include depression,
skin rashes, loss of coordination, speech problems and extreme fatigue. Discuss
any of these side effects with your doctor as soon as possible. Many people with
epilepsy use these medications for years without significant problems. Ask your
doctor to explain these issues to you when you receive the prescription.
To achieve the best seizure control possible, take medications exactly as
prescribed. Some seizure medications increase the risk of birth defects, so if
you're a woman with epilepsy tell your doctor if you're considering becoming
pregnant.
Surgery
Some people with epilepsy have seizures that medications can't control,
because the drugs either cause intolerable side effects or don't provide
satisfactory seizure control. In such cases, surgery may be an option.
Surgery is most commonly done when seizures occur in the side regions
(temporal lobes) or the front regions (frontal lobes) of the brain. Surgery is
rarely an option if you have seizures that start in several areas of the brain
or if you have seizures originating from a region of the brain that contains
vital brain functions.
During the procedure, your surgeon makes an incision in your scalp and
removes a piece of the skull bone. Using electrical recordings that monitor
brain activity, the surgeon cuts into or removes the area of the brain that's
causing the seizures. After surgery, many people continue to need some
medication to help prevent seizures.
Surgery likely won't be performed if seizures occur in an area of the brain
that involves vital functionality, such as movement, language, memory or vision.
...
Other approaches
Other treatment options for epilepsy may include:
A ketogenic diet.
This complicated, rigid
approach involves a high-fat, low-carbohydrate, low-protein diet. The
diet's name comes from ketones, chemicals produced when your body uses
more fat for energy than it normally does. Exact amounts of specific foods
and beverages are prescribed for each meal. The diet is so sensitive that
even a tiny intake of sugar can significantly reduce the amount of ketones
produced. It's not clear how the diet works to reduce seizures. But in the
early part of the 20th century, doctors observed that children with
seizure disorders who starved had improved control of seizures.
Vagus nerve stimulation. A device called a
vagus nerve stimulator may be a treatment option if medications are
ineffective or cause serious side effects. The stimulator is implanted
into your chest under the collarbone. Wires from the stimulator are
wrapped around the vagus nerve in your neck. The vagus nerve connects the
lower part of your brain to your heart, lungs and gastrointestinal tract.
The device turns on and off according to an adjustable program,
stimulating your brain. It's not clear how brain stimulation via the vagus
nerve inhibits seizures.
Understanding your condition can help you control it. Be sure to take your
medication correctly. Don't take it upon yourself to adjust your dosage levels.
Instead, talk to your doctor if you feel something should be changed.
It's also important to keep a detailed seizure record. This record can help
your doctor better understand your condition and may help direct your treatment.
Each time a seizure occurs, write down the time, the type of seizure it was and
how long it lasted. Also make note of any unusual circumstances, such as changes
in medication, increased stress or other events that might trigger seizure
activity. Seek input from people who may observe your seizures including
family, friends and co-workers so that you can record information you may not
know.
As with many chronic conditions, maintaining your overall health is an
important step in controlling epilepsy. Make a conscious effort to eat a
balanced diet, exercise, get enough sleep, manage stress effectively and limit
your alcohol intake.
Wear a medical bracelet to help emergency personnel. The bracelet should
state who to contact in an emergency and what medications you use. Any allergies
to medications also can be noted.
Coping skills
Each person who has epileptic seizures experiences them in a different way.
Many people gain complete control of seizures as soon as they begin treatment.
Other people take longer to find the right treatment regimen, and some people
may never have complete seizure control.
As is the case with other chronic conditions, having epilepsy may cause you
to experience emotional or psychological stress. The stress may be due to
personal difficulties in adjusting to epilepsy. You may have to give up some of
your independence for a period of time, including driving. You may also
encounter stressful relationships with family and friends because of your
condition. Following these tips may help you cope with your condition:
Know what to expect.
Find out everything you
can about your condition and how to treat it. The more you know, the more
active you can be in your own care.
Be proactive. Although you may feel tired and
discouraged, don't simply let others including your family or your
doctor make important decisions for you. Take an active role in your
treatment.
Maintain a strong support system. Having a
support system can help you cope with any issues and anxieties that might
occur. Although friends and family can be your best allies, the concern
and understanding of a formal support group or others coping with epilepsy
also may be helpful. Support groups also can be a good source of practical
information. You may find you develop deep and lasting bonds with people
who are going through the same things you are.
Set reasonable goals. Having goals helps you
feel in control and can give you a sense of purpose. But be realistic
don't choose goals you can't possibly reach. It may take time to get your
condition under control, so be patient.
Take time for yourself. Eat well, exercise and
get plenty of rest. Also, plan ahead for the times when you may need to
rest more or limit what you do.
Stay active. Receiving the diagnosis of
epilepsy doesn't mean you have to stop doing the things you enjoy or
normally do. You may have to modify activities such as driving, but you
can still lead a full and active life.
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"A foolish faith in authority is the worst enemy of truth."
-- Albert Einstein, letter to a friend, 1901
"I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education."
-- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820
"What's the point of vaccination if it doesn't protect you from the unvaccinated?"
-- Sandy Gottstein
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