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Drug-induced autoimmunity
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 Drug-induced autoimmunity. Pichler WJ. Clinic for Rheumatology, University of Bern, Bern, Switzerland. werner.pichler@insel.ch PURPOSE OF REVIEW: Presentation of different mechanism of drug-induced autoimmunity and highlighting of new developments. RECENT FINDINGS: Drugs can induce autoimmune diseases by their pharmacological properties. Injection of certain drugs into the thymus can alter positive selection in the thymus and elicit autoimmune reactions. Peripheral tolerance can be broken by increasing the expression of LFA-1 adhesion molecule on T cells. This can be related to the inhibition of intracellular kinases. Alternatively, a drug specific immune response might elicit autoimmunity by cross-reactivity: the drug reactive T cells might be cross-reactive with certain peptide antigens and possibly autoantigens. SUMMARY: Drug-specific immune responses are well described. They have a great tendency to be cross-reactive with peptide antigens. This 'immunological' cause of autoimmunity elicited by drugs may occur more frequently than thought. It connects the field of drug hypersensitivity with drug-induced autoimmunity. PMID: 12865767 [PubMed - in process]
Return to Vaccination News Home Page __» Right-click to "open in new window" DISCLAIMER: All information, data, and material contained, presented, or provided here is for general information purposes only and is not to be construed as reflecting the knowledge or opinions of the publisher, and is not to be construed or intended as providing medical or legal advice. The decision whether or not to vaccinate is an important and complex issue and should be made by you, and you alone, in consultation with your health care provider.
DISCLAIMER: All information, data, and material contained, presented, or provided here is for general information purposes only and is not to be construed as reflecting the knowledge or opinions of the publisher, and is not to be construed or intended as providing medical or legal advice. The decision whether or not to vaccinate is an important and complex issue and should be made by you, and you alone, in consultation with your health care provider.
Copyright 2012 by Vaccination News, A Non-Profit Corporation. All Rights Reserved. This content may not be copied unless permission in writing from Sandy Gottstein has been obtained. 
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 "A foolish faith in authority is the worst enemy of truth." -- Albert Einstein, letter to a friend, 1901 "I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education." -- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820 "What's the point of vaccination if it doesn't protect you from the unvaccinated?" -- Sandy Gottstein "Who gets to decide what the greater good is and how many will be sacrificed to it?" -- Sandy Gottstein |
