Developmental factors associated with risk for atopic disease: implications for vaccine strategies in early childhood.

> Developmental factors associated with risk for atopic disease: implications for vaccine strategies in early childhood.

   

Return to Vaccination News Home Page  __»   Right-click to "open in new window"

Subscribe to the Vaccination NewsLetter

View past & current Scandals (columns by Sandy Mintz)

Search This Site using keywords

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12850354&dopt=Abstract

 
1: Vaccine. 2003 Jul 28;21(24):3432-5. Related Articles, Links
Click here to read 
Developmental factors associated with risk for atopic disease: implications for vaccine strategies in early childhood.

Holt PG, Rowe J, Loh R, Sly PD.

Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, P.O. Box 855, Perth,WA 6872, Australia. patrick@ichr.uwa.edu.au

There is growing interest in the potential interactions between infant vaccination and risk for development of atopic disease. The aspect of this issue which has dominated this debate concerns suggestions that infant vaccination may stimulate allergic sensitisation. These suggestions derive from retrospective epidemiological analyses and will remain speculative unless they can be confirmed in prospective studies, particularly as conflicting findings have been reported. However, there is a potentially more important issue surfacing in this debate, which entails the converse situation, i.e. that genetic risk for atopy influences capacity to respond to vaccination during infancy. Support for the latter possibility comes from recent studies on the role of developmental factors which determine immune competence during infancy, and attendant risk for inflammatory and infectious diseases. The relevant findings are reviewed briefly below.

Publication Types:
  • Review
  • Review, Tutorial


PMID: 12850354 [PubMed - indexed for MEDLINE]
 

Return to Vaccination News Home Page  __»   Right-click to "open in new window"

DISCLAIMER:    All information, data, and material contained, presented, or provided here is for general information purposes only and is not to be construed as reflecting the knowledge or opinions of the publisher, and is not to be construed or intended as providing medical or legal advice.  The decision whether or not to vaccinate is an important and complex issue and should be made by you, and you alone, in consultation with your health care provider.