Effectiveness of a mass hepatitis A vaccination program in preadolescents

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http://www.elsevier.nl/gej-ng/10/42/35/80/48/50/abstract.html

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Vaccine, Vol. 21 (7-8) (2003) pp. 698-701
© 2002 Elsevier Science Ltd. All rights reserved.
PII: S0264-410X(02)00583-2
 

Effectiveness of a mass hepatitis A vaccination program in preadolescents

Àngela Domínguez * angelad@dsss.scs.es , Lluís Salleras, Glòria Carmona and Juan Batalla

Department of Health and Social Security, General Directorate of Public Health, Generalitat of Catalonia, Travessera de les Corts, 131-159, 08028 Barcelona, Spain

Abstract

A program of mass hepatitis A+B vaccination in preadolescents in schools was begun in the Catalonia in the last quarter of 1998. This study investigated the impact of the program by comparing the incidence of hepatitis A in vaccinated and unvaccinated cohort.

The greatest reduction of the incidence rate of hepatitis A was observed in the 10-14 years age group, from 10.3 per 100,000 persons-year in the period 1996-1998 to 1.8 per 100,000 persons-year in the period 1999-2001. The global incidence decreased from 6.2 to 2.6 per 100,000 persons-year.

After analysis of cases occurring in the vaccinated and non vaccinated cohort, the effectiveness of the vaccination program was estimated at 97.0% (95% CI: 78.6-99.6).

Keywords: Hepatitis A + B vaccine; Effectiveness; Hepatitis A incidence

*Corresponding author. Tel.: +34-93-227-2951; fax: +34-93-227-2921.

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