Scientists call it M.E.G. — short for Magnetoencephalography — a
scanner capable, unlike any before it, of showing activity in the brain
as it happens.
"If the brain is trying to do something with information from the
outside world, and all the different parts are working a little bit out
of synchronization, then the whole picture won't emerge in a coherent
kind of way," said Claudia Tesche, a psychologist who helped design the
scanner. "We need to know how the brain is processing information on a
moment-to-moment basis."
"We can look at changes in brain activity on a millisecond level,"
said Cheryl Aine of the University of New Mexico, one of the leading
researchers in the field.
Electrochemical Signals
The M.E.G. scanner makes that possible because the brain actually
runs on tiny pulses of electricity. Every thought, every reaction you
have to something, becomes a series of minute electrochemical signals
among the cells in your brain.
Weak as those signals are, they can be measured by the 122 sensors in
the M.E.G. scanner that surround one's head. The scanner is extremely
sensitive, and must be shielded so that it is not overloaded by all the
other electromagnetic noise around us. Its ability to detect brain
signals amid everything else, says one researcher, is comparable to
"being able to hear an insect's footsteps — at a rock concert."
"We can get a picture — a very clear picture — of what's going on
inside someone's head without touching them at all," said Michael
Weisend, a researcher who has worked extensively with M.E.G. "You just
get to sit down and look at the operation of the living brain."
In the imaging center at the New Mexico Federal Medical Center in
Albuquerque, we were introduced to a woman named Annie. Three years ago,
she began to show symptoms of schizophrenia — unable to distinguish
reality from illusion.
"I started getting paranoid that they were going to come and kill me
while I was sleeping, and so I started sleeping in my car," she said.
With medication, she's now much better, but doctors would like to
know what goes on inside her head. So Aine ran her through a test of
cognitive abilities, while she sat with her head in the scanner.
Order and Chaos
When the results are processed by computer, they generally show the
workings of the human brain to be remarkably orderly. If an image is
flashed on a screen in front of a healthy person, for example, the
scanner shows a response in a region in the back of the brain that
processes vision.
A
spoken word can trigger brain activity that gets transferred to the
frontal lobe. (ABCNEWS.com)
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If the image happens to be of a word, the activity will transfer to
the frontal lobe, which handles higher logic and language. The M.E.G.
scan shows that all this happens in about half a second.
"The schizophrenic doesn't do that," said Tesche. "The activity keeps
fluttering around from one brain area to another."
The result is chaos — a harmless picture may inadvertently be
processed by parts of the brain that usually process touch, or taste, or
even fear. It may, scientists surmise, explain why people with
schizophrenia sometimes hallucinate.
But researchers now have unprecedented ability to see what is going
wrong in the brain — in schizophrenia, epilepsy, and many other
disorders — and, perhaps, armed with the new information, find cures.

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