(CBS) Non-Hodgkin's lymphoma is the fifth most common cancer in the
U.S. and there's currently no cure. But researchers may soon have a new
weapon to fight one common form of the disease.
Dr. Mallika Marshall of CBS affiliate WBZ-TV in Boston reports that
a new vaccine may be a step in the right direction.
The most common symptom of non-Hodgkin's lymphoma is a painless swelling
of lymph nodes that occurs in the neck or under the arms. Some people may
also experience swelling of lymph nodes in other parts of the body,
including the groin, legs and ankles. Other patients complain of fever,
unexplained weight loss, night sweating, chills and lack of energy.
Dr. Marshall says it's important to know that pain won't be felt in the
early stages of the disease. The symptoms mimic those of other less
serious illnesses. So if symptoms are persistent, you should contact your
doctor.
Conventional cancer treatments, such as chemotherapy and radiation, often
become less effective the longer they are used in patients with
Non-Hodgkin's Lymphoma. This is why scientists are so eager to develop
viable alternatives.
Doctors hope the same cancer cells that infected his lymph node will now
save Michael Peterson's life.
"We are at a point where the ones in my abdomen are getting big," says
Peterson.
Six years after he was diagnosed with a slow-spreading form of
non-Hodgkin's lymphoma, Peterson's doctors are treating his disease more
aggressively, beginning with the removal of the diseased lymph node on his
neck.
The node is being used to create a personalized vaccine. Personalized
vaccines are part of a growing trend in cancer research in which
treatments are tailored to each patient's individual cancer.
"The idea of the vaccine is that the tumor cells have molecules on their
surface that are present only on the tumor and not on any other cells,"
says Cornell Medical Center's Dr. John Leonard.
Scientists take the tissue sample, identify that molecule and replicate
it.
The tissue is then injected back into patient. The hope is that it will
teach the body to recognize the cancer molecules and fight them wherever
they are present.
"The chemo did what it was supposed to do. Now we are hoping the vaccine
will keep it in remission for a longer period of time," says non-Hodgkin's
lymphoma patient Patricia Melchiorre.
This vaccine therapy is relatively free of toxicity and leaves healthy
cells unharmed, so patients tend not to have serious side effects.
A longer remission would be considered an advance for a disease without a
cure. The trial in which Melchiorre and Peterson are participating is
blind, meaning neither of the two knows if he is getting their own vaccine
or a dummy vaccine. Both patients have about a two-thirds chance of
getting the actual vaccine.
Dr. Marshall says there are other medications on the horizon to treat
non-Hodgkin's lymphoma.
Last month, a panel of expert advisors to the U.S. Food and Drug
Administration recommended approval of the drug Bexxar. This development
comes after the FDA rejected an application by Bexxar's manufacturer,
saying there was not enough proof of safety and efficacy. The decision was
appealed and new data was presented.
The FDA typically follows its committees' recommendations and has until
May to decide whether the drug can be offered on the market.
ALL INFORMATION, DATA, AND
MATERIAL CONTAINED, PRESENTED, OR PROVIDED HERE IS FOR GENERAL INFORMATION
PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS REFLECTING THE KNOWLEDGE OR OPINIONS
OF THE PUBLISHER, AND IS NOT TO BE CONSTRUED OR INTENDED AS PROVIDING MEDICAL OR
LEGAL ADVICE. THE DECISION WHETHER OR NOT TO VACCINATE IS AN IMPORTANT AND
COMPLEX ISSUE AND SHOULD BE MADE BY YOU, AND YOU ALONE, IN CONSULTATION WITH
YOUR HEALTH CARE PROVIDER.
"A foolish faith in authority is the worst enemy of truth."
-- Albert Einstein, letter to a friend, 1901
"I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education."
-- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820
"What's the point of vaccination if it doesn't protect you from the unvaccinated?"
-- Sandy Gottstein
"Who gets to decide what the greater good is and how many will be sacrificed to it?"