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http://www3.interscience.wiley.com/cgi-bin/abstract/102530874/START
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Online ISSN: 1097-0215 Print ISSN: 0020-7136 Copyright © 2003 Wiley-Liss, Inc. |
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Epidemiology
| Childhood cancer in relation to infections in the community during pregnancy and around the time of birth |
Tibor A. Nyari, Heather O. Dickinson, Louise Parker
* |
| North of England Children's Cancer Research Unit, Department of Child
Health, University of Newcastle, Royal Victoria Infirmary, Newcastle upon
Tyne, United Kingdom |
| email: Louise Parker (louise.parker@ncl.ac.uk) |
*Correspondence to Louise Parker, North of England Children's Cancer Research Unit, Department of Child Health, University of Newcastle, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK
Fax: +44-191-202-3060 or
+44-191-202-3022
Funded by:
North of England Children's Cancer Research Fund
Tyneside Leukaemia Research Fund
| Keywords |
| children's cancer • epidemiology • infections |
| Abstract |
| In a retrospective cohort study of 404,106 live births in the northern region of England, 1975-1986, we investigated whether higher levels of community infections during the mother's pregnancy and in early life were risk factors for cancer, by diagnostic group (leukaemia and non-Hodgkin's lymphoma, Hodgkin's disease, brain/spinal tumours, neuroblastoma, other tumours), diagnosed 1975-2001 under age 15 years. Logistic regression was used to relate risk to measures of community infections (measles, respiratory and other infections) in 3 prenatal and 2 postnatal quarters. There was an increased risk of Hodgkin's disease among children exposed around birth to higher levels of measles (odds ratio for trend = 2.3, 95% confidence interval 1.3-4.2, p = 0.01). For other diagnostic groups, there was no consistent evidence of an association between risk and exposure to infections. Although the significant association observed for Hodgkin's disease may be a chance finding, consequent to multiple hypothesis testing or the ecologic nature of the study, it is consistent with other recent epidemiologic results suggesting that the risk of Hodgkin's disease may be associated with exposure to infections. © 2003 Wiley-Liss, Inc. |
Received: 28 June 2002; Revised: 13 November 2002; Accepted: 4 December 2002
| Digital Object Identifier (DOI) |
10.1002/ijc.11030 About
DOI
| References are available in the Enhanced Abstract |
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