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Collections under which this article appears: Drugs: immunological products and vaccines Children

Archives of Disease in Childhood 2003;88:222-223
© 2003 BMJ Publishing Group & Royal College of Paediatrics and Child Health
 

Bacterial infections, immune overload, and MMR vaccine

E Miller¹, N Andrews², P Waight¹ and B Taylor³

¹ Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service, 61 Colindale Avenue, London NW9 5EQ, UK
² Statistics Unit, Public Health Laboratory Service
³ Centre for Community Child Health, Royal Free and University College Medical School, Royal Free Campus, University College London, London NW3 2PF, UK

Correspondence to:
Dr E Miller, Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service, 61 Colindale Avenue, London NW9 5EQ, UK;
emiller@phls.org.uk

ABSTRACT
Combined measles, mumps, and rubella (MMR) vaccine did not increase the risk of hospitalisation with invasive bacterial infection in the three months after vaccination; rather there was a protective effect. These results provide no support for the concept of "immunological overload" induced by multiple antigen vaccinations, nor calls for single antigen vaccines.

Keywords: MMR vaccine; vaccine safety; immune interference; immune overload

Abbreviations: MMR, measles, mumps, and rubella; RI, relative incidence

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