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Association Between Antibiotic Use and
Primary Idiopathic Intussusception Background Intussusception is the leading cause of intestinal obstruction in young children. Antibiotics are the most frequently prescribed medication in the pediatric population and have common adverse effects on the gastrointestinal tract. Objective To determine whether a relationship exists between primary idiopathic intussusception and antibiotic drug use. Design Case-control study. Participants Ninety-three case patients with intussusception and 353 injury controls younger than 4 years who were seen at the emergency department of the Children's Hospital of Alabama between January 1, 1996, and April 30, 2001, were included. Controls were matched to cases by quarter and year of time of diagnosis, age, and sex. Main Outcome Measures Odds ratios and 2-sided 95% confidence intervals were estimated using conditional logistic regression. Prevalence of antibiotic use in an age-standardized, representative sample of US children from NHANES III (Third National Health and Nutrition Examination Survey) was used for external comparisons. Results Antibiotic use within 48 hours of diagnosis was found in
23 cases (25%) and 33 controls (9%) (odds ratio, 4.15; 95% confidence
interval, 2.17-7.92; attributable risk, 18.7%). Antibiotic use among US
children according to NHANES III was 10.7%. In cases, the
Conclusion An association between antibiotic drug use and intussusception was identified. Arch Pediatr Adolesc Med. 2003;157:54-59
View Full Text Accepted for publication August 6, 2002. This study was supported in part by the National Institutes of Health Short Term Student Training in Health Professional Schools grant T35-HL07473 from the University of Alabama at Birmingham School of Medicine. This study was presented in part at the Pediatric Academic Societies Meeting, Baltimore, Md, May 4, 2002. We thank the medical records department at the Children's Hospital of Alabama for their tremendous support during the study; Carden Johnston, MD, Pete Glaeser, MD, and Kathy Monroe, MD, for their careful review of the manuscript; and Cathryn Powers, BS, for her diligent work in medical abstraction.
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© 2003 American Medical Association. All rights reserved. |
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