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SCHAFER AUTISM REPORT "Healing Autism:
No Finer a Cause
on the Planet"
________________________________________________________________
December 12 & 15,
2003 PART 1 Vol. 7 Nos. 247 & 248
** Today’s newsletter is in
two parts. This is the first.
MEDIA
* MMR R.I.P.?
* Doctors’ Fury At
MMR Drama ‘Errors’, Reports Channel to Regulators
* Channel Defends MMR Jab Drama
MMR RIP?
[This article is not available online
without a subscription to the Sunday Times Magazine. Because of this, and
because this is a significant milestone in the mysteries of autism, we are
presenting it in its entirety. Today’s Schafer autism report will be in two
parts as a result. Report By Robert Sandall for The Sunday
Times Magazine.] http://www.timesonline.co.uk/article/0,,2099-931673_1,00.html
A conspiracy of silence
or paranoid scaremongering? Is the MMR vaccine a cause of autism — or is
it a vital health programme undermined by this
medical maverick? In March, seven
mentally disturbed British children and an escort of parents, carers, two doctors and three lawyers flew to
Over the course of a year, the 246
private and NHS hospitals in
It was an arguable point. Before an
illness can be treated, it must be fully understood, and the root of these
children's problems hadn't been ascertained. By the time a hospital outside
On the night before the children arrived
at the hospital, lawyers acting for GlaxoSmithKline
(GSK), Merck and Aventis Pasteur MSD, manufacturers
of the MMR triple vaccines that have been used in the
The children were the claimants in a
“class action” — legal-speak for a case launched jointly by victims with the
same grievance. If successful, it would validate the claims of 1,300 other
British families and trigger international damages awards that could top $1
trillion. The proposed test, to look for traces of measles-vaccine virus in the
children's CSF, could provide evidence that it can pass from the gut's lining
into the brain, where measles is known to affect cerebral processes.
This is one of the most contentious
issues in the row about what, if anything, brings on a
disease described, but not universally accepted, as “autistic enterocolitis”. In the
The theory that a malfunctioning or
“leaky” gut sends partially digested food — in the form of opioid
compounds known as peptides — up to the brain is one of the less controversial
aspects of the hypothesis under investigation. Whether measles vaccine is what
gives rise to the gut disease in the first place is the trillion-dollar
question. So far, the sum of Wakefield et al's discoveries has not met the
exacting medical standards that establish causation. All it points to is an
“association”. But the importance of the spinal-fluid link was well understood
by the defendants in the class action. Merck's QC had recently referred to it
in court as “a significant result when trying an issue as to whether or not MMR
vaccine causes autism”.
Time was running out for the claimants.
Their action was being financed by the Legal Services Commission (LSC), a
successor to the Legal Aid Board, which had set a July deadline for the
submission of expert medical evidence, after which funding would be reviewed.
Having lost a year trying to get the CSF samples in the
. . .THESE
INTERVENTIONS MIGHT, JUST MIGHT, HAVE BEEN
ORCHESTRATED TO DELAY DELIVERY OF THE
SAMPLES, ALLOWING THEM TO
SPOIL. SO WHEN THE VIROLOGIST IN THE
PARTY, COLIN FINK, GOT THEM
BACK TO HIS PRIVATE LAB, MICROPATHOLOGY,
IN
UNUSUAL PRECAUTION OF
PLACING AN ARMED GUARD OUTSIDE OVERNIGHT.
Another bid by the defendants to secure
an injunction, this time in the
Although lumbar taps on autistic children
are common in the
But the children's camp had an
undisclosed back-up plan. They had made an arrangement with another hospital in
Now the party and the fluid samples had
to be flown home for analysis. There was bedlam on the bus as the anaesthetic wore off: one child tried to exit the moving
vehicle by the back door, while another was restrained by his mother in the
toilet. At the airport, the container of dry ice carrying the CSF was deemed
too large to be carried on as hand luggage, and another business-class seat had
to be specially purchased for it.
After the KLM flight had boarded, five US
customs officers arrived to take the lawyers and doctors off the plane — the
only passengers they apprehended — for separate, 30-minute taped interviews.
They weren't asked any questions pertaining to passenger safety and their large
container: the issue was why the children hadn't been tested back in the
By now, several tired minds were stoking
their paranoia that these interventions might, just might, have been
orchestrated to delay delivery of the samples, allowing them to spoil. So when
the virologist in the party, Colin Fink, got them back to his private lab, Micropathology, in
The next day the CSF samples were
couriered to their final
destination: Professor John O'Leary's
laboratory at
The analysis proceeded: three of the six
samples tested positive for the vaccine strain of measles virus, but only in
minuscule genetic fragments — and not enough to count as a valid research
sample. According to medical-research protocol, that
result had now to be compared to the CSFs of a
“control” group of non-autistic patients. Acquiring these took several months,
during which the claimants missed the LSC's July
deadline and had their funding temporarily suspended awaiting an appeal on
September 30.
When the doctors finally assembled their
evidence, the children's lawyers felt confident. Only 1 in 20 of the control
group — all leukaemia sufferers, specifically chosen
for their high susceptibility to random viral infections — was found to be
carrying measles virus in their CSF.
The defendants' analysis of the same
samples, carried out by Dr Peter Simmonds at
The claimants' lawyers suspected that the
committee had made up their minds before considering the CSF test results, as
these offered fresh evidence of just such a link. At the hearing, they were
told to await a decision at the end of the day, and written reasons for it two
days later. But if the answer was yes, they wondered, why would the reasons not
be immediately forthcoming? They were
not reassured to discover, when they looked more closely, that the LSC's e-mailed press release dropping the case had been
originated the day before the hearing.In a footnote
to editors, the LSC admitted that its decision reflected a change of policy
rather than an assessment of evidence. “In retrospect it was not appropriate
for the LSC to fund research. The courts are not the place to prove new medical
truths.” That judgment is itself up for judicial review in the new year — though the LSC is not bound to accept its
recommendations.
Paranoia is currently the default mood on
all sides of the MMR debate. The British government is so scared of it that
health ministers will not be interviewed on it. The drug companies are on the
defensive against damages claims that, if proven, could seriously undermine
their credibility and their business. And the anti-MMR lobby is convinced a
coalition of government agencies, the medical Establishment and big pharma are against them, X-Files style.
In a leafy southwest-London suburb, the
man whose 1998 paper in The Lancet kicked off the fracas, Dr Andrew Wakefield,
would prefer not to talk on the phone. He believes his line was tapped about
three years ago, and now conducts regular “sweeps” to check it for bugs.
Visiting the house whose garage has
served as his office since he resigned his post at
UP UNTIL 1998,
THAT AN INFLAMMATORY BOWEL DISEASE,
ULCERATIVE COLITIS, CAN BE
BROUGHT ON BY ARTERIAL PROBLEMS RATHER
THAN, AS WAS PREVIOUSLY
ASSUMED, BY A GUT FULL
OF GERMS, MADE HIS NAME.
In appearance he's like a genial fly
half, solidly built, with hooded, watchful eyes, a boyish grin and an easy manner.
What bothers him most, he says, is the way his research has been rubbished by
colleagues who deny gut treatment to children who, he believes, badly need it.
On his laptop is a photograph of Laurence, an autistic boy with a severely
distended belly, whose mother has been accused of starving him and was refused
access to a paediatric gastroenterologist. Next to
Laurence in the picture stands his healthy, unstarved
sister. This is a classic case of autistic enterocolitis,
says
But the way this data is compiled and
analysed is troubling. In
questions.) “It was a disgrace. We've
published a lot on this in eminent journals. The first we heard of that case
was when it was thrown out of court.”
Life was different before he and six of
his Royal Free team published their Lancet bombshell, the unexplosively
titled “Ileal-Lymphoid-Nodular Hyperplasia,
Non-Specific Colitis and Developmental Disorder in Children.” Up until 1998,
12 CASES. HIS
RESEARCH FACILITIES WERE CONTAMINATED. HE COULDN'T
REPLICATE HIS OWN
RESULTS.
Conventional diagnosis attributed the
concurrence of autistic behaviour and severe bowel
problems to coincidence, or held that disturbed minds naturally led to upset
tummies.
In the 12 cases that he and his team
examined in detail, the children's bowel problems coincided with evidence
suggesting that measles was lurking in the intestinal wall. Given the known
propensity of measles to linger in the gut and, in extreme cases, to attack the
brain, might this implicate MMR in their children's autism? It was, to put it mildly, an awkward
question.
And soon the fur started to fly.
The Department of Health (DoH) was not impressed. Despite Wakefield's submissions to
the then chief medical officer, Kenneth Calman, six
months prior to publication of the 1998 Lancet article, public-health officials
were understandably resistant to a hypothesis that queried their vaccination programme on the basis of one small group of children in
north London. But not as resistant as the drug companies who, as they generally
do in teaching hospitals, sponsored a large chunk of the Royal Free's research. Everybody, Wakefield and co included,
agreed that more studies were needed before MMR could be shown as a cause of
autism. Not everybody, though, was urging that these should take place.
"THE SCIENTIFIC ARGUMENT ON
MMR AND AUTISM IS OVER: MMR
VACCINE IS NOT INVOLVED". HE URGED
THE SUNDAY TIMES TO "DO SOMETHING
POSITIVE" FOR MMR AND FOR CHILDREN
WITH AUTISM, INSTEAD OF "ANOTHER
HALF-BAKED PANAGYRIC
[SIC] FOR JUNK SCIENCE".
-BRENT TAYLOR
In its 1988 HMSO Handbook of Vaccination
for Practitioners, the DoH claimed a 95% protection
rate for the rubella-and-measles single jabs. In its 1996 edition, post-MMR,
the measure of effective measles immunity had dropped to 90% — beneath the
threshold guaranteeing "herd immunity". But by now the DoH's data-collection system no longer recognised
single jabs in the compiling of individual health records. Today we are informed that MMR is more
effective than single vaccines, as well as unimpeachably safe. But government
ministers are reluctant to address the issue in detail, preferring to issue
bland reassurances such as the one the health secretary, John Reid, made on
GMTV in November: "It is unequivocal that there is no evidence at all that
MMR is linked to autism." Off the
record, however, DoH media briefers
acknowledge that MMR has become "too political". After receiving
wobbly guidance on poisoned eggs, mad-cow disease and the anti-arthritic drug Opren, the public no longer believes elected politicians on
health issues, so comments on MMR are kept to a minimum. David Salisbury has
presided over all vaccination programmes for the past 15 years, and currently
advises the junior minister for public health, Melanie Johnson.
Neither of them would speak to me about a
successor to MMR that was first revealed in the press in 1998, shortly before
the
up: recent press reports tell
of more tests on MMRV proceeding in
Autism is now referred to as a spectrum
disorder, a catch-all syndrome whose symptoms range from semi-suicidal lunges
out of windows to a relatively harmless obsession with order and routine.
That might be coincidence, and it might
be that as the spectrum of the disorder has broadened, we've got better at
spotting it.
Such reticence from the pro-MMR party
does not inspire confidence. Nor do their efforts to identify alternative
causes for the steep increase in diagnosed autism. The Medical Research Council
was given £2.75m by the DoH last year to fund new
research. So far, none of that money has been allocated, though 12 projects
are, it says, "under consideration". No details could be
supplied. Meanwhile a three-year study
that the MRC commissioned in 2000 from the
Tomorrow [Monday], Five
is scheduled to screen a TV drama, Hear the Silence, with Hugh Bonneville as
Andrew Wakefield and Juliet Stevenson as the mother of an autistic child
battling to get heard by an unsympathetic gang of haughty specialists. It is a
partisan account of the MMR story, so partisan that Five
has organised a televised discussion afterwards to
let the DoH answer back. At the time of writing, it
had not agreed to take part. The most misleading impression given by the drama
is its portrayal of
He presented a torrent of statistics
detailing an 800% increase in diagnosed cases of autism since
One was the meeting's concern that
anxieties about MMR had been hyped by our old enemy the media. The other was
its refusal to address the evidence that aroused public distrust in the first
place. For these people, immunisation was an incontrovertible religious
doctrine. Fitzpatrick rubbished the work of
Such a feeble defence of the status quo, and a blanking of public
anxieties that might be misguided but are nonetheless genuine, may suit
embattled drug companies and embarrassed government policy wonks. But it
isn't going to silence the enemies of multiple vaccination
— nor will it do much good for anybody's health.
NOTE: This is only being shown in the
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_______________________________________________________
* * *
Doctors’ Fury At MMR Drama ‘Errors’, Reports TV Channel to Regulators
[By Stephen Naysmith for the Sunday Herald.] http://www.sundayherald.com/38671
Doctors and scientists approached to take
part in a debate about a television drama based on the controversial MMR
vaccine have boycotted the discussion, and condemned the programme
as biased and riddled with errors.
They will also report the television
company, Channel Five, to the Independent Television Commission (ITC), which
has the power to take action against the company and the programme-makers.
Representatives of the Department of Health have also condemned the programme.
The drama, Hear The
Silence, features actress Juliet Stevenson as the mother who believes her
child’s autism has been caused by the combined vaccination against measles,
mumps and rubella. Although her story is fictional, many elements of it are
presented as fact, including the role of the other main character, Andrew Wakefield
– the real-life doctor who first voiced the possibility of a link between MMR
and autism.
A spokesman for the Royal Society said
last night that members were alarmed at the blurring of the distinction between
fact and fiction, especially the failure to include any reference to scientific
doubts over
“In dramatising
controversial scientific issues, it is vital that it is clear to the viewer
which bits are fiction and which factual,” he said. “TV is a powerful medium.
If you convey inaccurate information about issues of great public concern, that
is a disservice to the viewer. The scientific community will wait to see what
is broadcast tomorrow and whether it falls within the bounds of the ITC code. There
is a duty there not to mislead viewers into thinking information is being
presented which is accurate when it is not.”
The ITC code for programme-makers
places a duty on drama as well as factual programming to present accurate
information about major matters of public policy.
The medical community has been
particularly outraged by the programme, which many
fear will set back efforts to reassure parents about immunisation. In a
statement to be released tomorrow, four Royal Colleges and six leading child
health specialists will warn that the programme is
“misleading” and gives an “entirely unbalanced picture” of
“Our concern is that because this
one-sided and misleading film appears to be a documentary, with some key
players and places named, it will have undeserved credibility and inevitably
increase the anxieties of parents,” the statement warns.
“It would be a pity if the desire for
‘good’ television took precedence over the welfare of children.”
However, others have expressed regret
that those who reject
A spokesman for Channel Five said
elements of the film had been fictionalised but its
complainants were “missing the point”. Hear the Silence is screened tomorrow
[Monday] at
* * *
Channel Defends MMR Jab
Drama
[Jo Revill for The Observer.] http://media.guardian.co.uk/broadcast/story/0,7493,1106729,00.html
The makers of a TV drama about the MMR
vaccine, which stars Juliet Stevenson, yesterday defended her over remarks
about the safety of the jab.
Organisations
representing children's doctors and nurses had joined forces to denounce a
decision by Channel 5 to screen Hear The Silence,
tomorrow night.
The actor, who opted for single vaccines
for her son Gabriel, two, said she was astonished at how Dr Andrew Wakefield,
the man who first suggested a link between the vaccine and autism, appears to
have been ostracised by the medical establishment.
She said: 'There is a sort of hysteria
coming from the government at the moment, and you just can't go on telling frightened
people that they are wrong. You have to understand what the fear is. At the
moment, people are just being told, “Shut up and don't worry, have the MMR”.
It's very patronising.' The charity Sense, which
represents families whose children have become deaf or blind as a result of
rubella, criticised her for her remarks. Stephen
Rooney said: 'Juliet Stevenson has no scientific or medical expertise and yet
has given a number of interviews in which she has called into question the
safety of the vaccine.' But a spokesman for Channel 5 said last night that the
actor had every right to make her views known. 'Juliet Stevenson has never
claimed to be a medical expert. She is expressing her views as a mother.' The programme - which features Stevenson as a mother desperate
to see whether her son's autism is linked to the triple jab - has been greeted
with dismay by health professionals.
A statement signed by the heads of the
four Royal Colleges reads: ' Hear The Silence distorts
the truth in what can only be described as an irresponsible and reckless way.
Throughout the programme, the words, “there is a link
between MMR and autism” are stated by parents and
_______________________________________________________
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_______________________________________________________
_________________________________________________________________
Lenny Schafer, Editor mailto:edit@doitnow.com
Edward Decelie Debbie Hosseini Richard Miles
Ron Sleith
Kay Stammers
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