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The
anniversary has been marked with numerous exhibitions,
journal special issues, and meetings, not to mention a
bewildering array of commemorative publications, coins
and stamps.
This much is
understandable. After all, working out the double
helical structure of DNA was an unrivalled contribution
to science and society. But, say some, we would do well
to reflect on how one man, James Watson, has
single-handedly influenced what we know about and how we
are celebrating this discovery.
The structure
of DNA was revealed to the world in three articles in a
single issue of Nature published on 25 April
1953. The first of the trio of articles was the famous
letter by James D. Watson and Francis H.C. Crick that
brought them credit for unraveling the detailed
structure of the double helix, and simultaneously cast a
long shadow over the contributions of numerous other
researchers from whom Watson and Crick had drawn
inspiration and obtained data. Today, 50 years on, the
anniversary of the discovery is still under Watson's
influence, says Pnina Abir-Am, a historian of science at
Rockefeller University in New York.
"It is
totally dominated by one person, J.D. Watson, whose role
really was more of a science entrepreneur, collating the
work of others," said Abir-Am. "The discovery was made
by two scientists who never properly acknowledged the
work of others, most notably Franklin, Chargaff, Pauling
and Wilkins," she said. "It is incomprehensible how long
this unusual appropriation has been going on."
The first
published account of the events that lead Watson and
Crick, then working at the Cavendish Laboratory in
Cambridge, to piece together their famous model of DNA
was written by Watson himself in 1968. An instant best
seller, The Double Helix is widely recognized as
an exaggerated and subjective account of events. Indeed,
Watson admits as much in its subtitle, A Personal
Account of the Discovery of the Structure of DNA.
Nevertheless,
it is the most important factor behind the widespread
fascination with the double-helix story, says Darwin
Stapleton, executive director of the Rockefeller Archive
Center in New York. "I think Watson's book is the
largest single ingredient," said Stapleton. "For all its
flaws, it has engaged millions of people," he said.
"It's almost theater, and it's very powerful theater."
One of the
most dramatic aspects of Watson's book was the portrayal
of his relationship with Rosalind Franklin. "Rosalind
Franklin is ... a clear case of someone who didn't live
long enough to get the Nobel," said Stapleton.
Franklin was
a leading physical chemist at King's College London,
whose research involved taking unique X-ray photographs
of DNA. It was one of these photographs - the now famous
"photograph 51" - that, according to Watson's 1968
account (and reiterated subsequently), played a
revelatory role in the discovery, when Maurice Wilkins,
assistant head of Franklin's department, showed it to
Watson. "The instant I saw the picture my mouth fell
open and my pulse began to race," wrote Watson in The
Double Helix.
Whilst
Watson's excitement is understandable, for this was
indeed an exceptional photograph of the hydrated
'B-form' of DNA that revealed its helical nature, in
terms of the information it conveyed to Watson, it was
by no means unique, says Franklin's biographer, Brenda
Maddox. "There were many of them, and they'd all been
taking them with various degrees of success for many
years," she said. Maddox even suspects that photograph
51 was actually taken by Franklin's PhD student, Raymond
Gosling, whose role in the DNA drama is elaborated in a
news story on BioMedNet News. "I think you probably
could say that Gosling took it," she said.
In Watson's
dramatization, Gosling's contribution is virtually
ignored, agrees James Tait, who together with his late
wife Sylvia Simpson and Tadeus Reichstein revealed the
molecular structure of aldosterone in 1953, a discovery
that at the time received much wider publicity than did
the double helix. "I think the real martyr of the story
is Gosling and not Franklin," said Tait, who is to
publish a book on the events of 1953. "I don't suppose
Gosling would ever have got [the Nobel prize], but he
was involved in all the work," he said.
Although
Watson's adventitious glimpse of photograph 51
stimulated him to resume model building, a far greater
lead came from a Medical Research Council report on
King's College that Cavendish colleague, Max Perutz,
leaked to Watson and Crick the following week. This
contained details of Franklin and Gosling's research,
from which Crick would learn that DNA was comprized of
two helical and anti-parallel strands.
In spite of
this preview of Franklin and Gosling's unpublished data,
much of which appeared in the last of the trio of
articles in the 25 April 1953 issue of Nature,
Watson and Crick still included the following in their
letter: "We were not aware of the details of the results
presented there when we devised our structure ..."
And yet, in
spite of the debt owed to those at King's (and to
countless others, including Oswald Avery, Colin MacLeod
and Maclyn McCarty, Alec Stokes, Linus Pauling, Robert
Corey, Erwin Chargaff, and Jerry Donohue), the 50th
anniversary of the discovery is reinforcing rather than
reassessing the roles played by Watson and Crick, says
Abir-Am, who has written extensively on how scientists
celebrate their achievements. "There is ... little
effort in the so-called official manifestations to bring
to light new research that can still change dramatically
what we think we know of how this discovery was made,"
she said.
On 28th
February this year - which, according to Watson's
account, was exactly 50 years after Crick had "winged
into The Eagle [pub in Cambridge] and told everybody we
had found the secret of life," - Watson received a
standing ovation at a DNA gala dinner in New
York's Waldorf Astoria Hotel, says historian Stapleton.
The event was, in part, organized by Cold Spring Harbor
Laboratory, the institute that Watson has been president
and director of since 1968.
Crick, now
86-years old and too frail to attend in person, appeared
to the gathering on a TV screen and was applauded.
Archive footage of Rosalind Franklin, who died of cancer
in 1958, was also shown and brought cheers and tears
from the audience, says Stapleton. But the physical
absence of these two key players in the DNA story
allowed Watson to assume center stage.
"The
scientific community is a monkey society, and ... he is
an alpha male by virtue of associating his name with an
important discovery while spreading a lot of smokescreen
to deflect attention form the fact that most of the work
had already been done by others," said Abir-Am, who
suspects that historians will only be able to get at the
truth of the double helix once Watson is out of the
picture. "In any case, where you have a very dominant
figure, à la Stalin and co., once the person is dead the
beta monkeys are less intimidated and will start
volunteering more info," she said.
The 50th
anniversary of the double helix has been "vastly
exaggerated," concludes Abir-Am. Scientific
anniversaries, she warned, are used "to push for agendas
in the present, and almost not at all to gain a better
understanding of the past."
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