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Mercury Free and Healthy - the first wealth is healthVaccination News Home Page subscribe Vaccination NewsLetter Mercury Free and Healthy "the first wealth is health" Ralph Waldo Emerson "Diseases are crises of purification, of toxic elimination." Hypocrites, 500 BC "a terrible sin against humanity" Dr. Alfred Stock, 1926
Ever since dentists first started installing amalgams in patients' teeth there has been an issue as to whether the dose of mercury is released from them and causes health (pathophysiologic) problems. This web page presents information pertaining to the dental amalgam issue. Subjects presented in the contents list are linked to subsequent portions of the web page. Contents List II) Paramount
Scientific Documents III) Fetal
Malformations IV)
Alzheimer's Disease Studies VI) Dental
Mercury A Source of Air and Water Pollution VII) American
Dental Association's (ADA) Position VIII) Composite Restoration Material IX) State
Statute XI) Notice to Amalgam Manufactures XVII) Amalgam Related Conventions XVIII) Request for Finincial Support of Web Page IXX) The Mercury Free and Healthy Campaign (Bumper Sticker Orders) XX) DAMS PRESS
RELEASE I) Introduction Ever since dentists first started installing amalgams in patients' teeth there has been an issue as to whether mercury is released and causes health (pathophysiologic) problems. Then in 1984 a group of conscientious dentists formed the International Academy of Oral Medicine and Toxicology (IAOMT). One of their objectives was to scientifically explore the safety of amalgam restorations. Since 1984, members of the IAOMT have inspired many renowned medical scientists at universities around the world to research possible pathophysiologic effects associated with mercury leaking from amalgam restorations. Consequently, there are a growing number of scientific studies that document pathophysiologic effects associated with amalgam mercury. I a) Fundamental Health Flaws A "silver filling" is a euphemism for an amalgam restoration, which a dentist places in a patient's tooth after a cavity is created by drilling out decay. Amalgam restorations consist of mercury, silver, tin, copper, and a trace amount of zinc. The dental amalgam has two fundamental flaws that adversely effect a patient's health. The first fundamental flaw is that all amalgam metals are cations. The net result of the tendency for covalent, ionic and metallic bonding and van der Waals forces between amalgam cations is a weak repulsion. So there is a sustained release of mercury and other metals from the amalgam into the body. Researchers have measured a daily release of mercury on the order of 10 micrograms from the amalgam into the body. Mercury is a toxic metal; the most minute amount damages cells. The second fundamental flaw is that there are five dissimilar metals in the amalgam. Galvanic action between these metals in inevitable (the dissimilar metals form a battery). Galvanism produces electricity that flows through the body. The electric currents produced by the amalgam typically are between 0.1 and 10 microamps, compared to the body's natural electric current of 3 microamps. The mercury challenges systemic functions of every individual and of developing fetuses, so it can lead to health problems and fetal malformations. Mercury leakage and its subsequent pathophysiologic effects are most often slow, insidious processes. So health problems caused by dental mercury poisoning are perceived many years after the amalgams are placed. I b) The Truth and the Hippocratic Oath Arthur Schopenhauer, 19th Century Philosopher ..."All truth passes through three stages: first it is ridiculed, second it is violently opposed, and third it is accepted as self-evident." "...I will prescribe regimen for the good of my patients according to my ability and my judgment and never do harm to anyone. To please no one, will I prescribe a deadly drug nor give advice which may cause his death. If I keep this oath faithfully, may I enjoy my life and practice my art, respected by all men and in all times; but if I swerve from it or violate it, may the reverse be my lot." I c) Historical Overview of Mercury Use in Dentistry
As early as the 7th century, the Chinese used a "silver paste" containing mercury (Hg) to fill decayed teeth. Throughout the Middle Ages, alchemists in China and Europe observed that this mysterious silvery liquid, extracted from cinnabar ore, was volatile and would quickly disappear as vapor when mildly heated. Alchemists were fascinated that at room temperature Hg appeared to "dissolve" powders of other metals such as silver, tin, and copper. By the early 1800's, the use of a Hg/silver paste as a tooth filling material was being popularized in England and France and it was eventually introduced into North America in the 1830s. Some early dental practitioners expressed concerns that the Hg/silver mixture (amalgam) expanded after setting, frequently fracturing the tooth or protruding above the cavity preparation, and thereby prevented proper jaw closure. Other dentists were concerned about mercurial poisoning, because it was already widely recognized that Hg exposure resulted in many overt side effects, including dementia and loss of motor coordination. By 1845, as a reflection of these concerns, the American Society of Dental Surgeons and several affiliated regional dental societies adopted a resolution that its members sign a pledge not to use amalgam. Consequently, during the next decade some members of the society were suspended for the malpractice of using amalgam. But the advocates of amalgam eventually prevailed and membership in the American Society of Dental Surgeons declined, forcing it to disband in 1856. In its place arose the American Dental Association, founded in 1859, based on the advocacy of amalgam as a safe and desirable tooth filling material. Shortly thereafter, tin was added to the Hg/silver paste to counteract the expansion properties of the previous amalgam formula. There were compelling economic reasons for promoting dental amalgam as a replacement for the other common filling materials of the day such as cement, lead, gold, and tinfoil. Amalgam's introduction meant that dental care would now be within the financial means of a much wider sector of the population, and because amalgam was simple and easy to use, dentists could readily be trained to treat the anticipated large number of new patients. By 1895, the dental amalgam mixture of metals had been modified further to control for expansion and contraction, and the basic formula has remained essentially unchanged since then. Scientific concerns about amalgam safety initially surfaced in Germany during the 1920's, but eventually subsided without a clear resolution. At the present time, based on 1992 dental manufacturer specifications, amalgam (at mixing) typically contains approximately 50% metallic Hg, 35% silver, 9% tin, 6% copper, and a trace of zinc. Estimates of annual Hg usage by U.S. dentists range from approximately 100,000 kg in the 1970's to 70,000 kg today. Hg fillings continue to remain the material preferred by 92% of U.S. dentists for restoring posterior teeth. More than 100 million Hg fillings are placed each year in the U.S. Presently, organized dentistry has countered the controversy surrounding the use of Hg fillings by claiming that Hg reacts with the other amalgam metals to form a "biologically inactive substance" and by observing that dentists have not reported any adverse side effects in patients. Long-term use and popularity also continue to be offered as evidence of amalgam safety. Id) Has the US Food and Drug Administration Approved the Mixed Dental Amalgam? The simple answer is NO! What the FDA has done is to approve the two components that make up amalgam i.e, mercury and dental alloy, but have not seen fit to approve ''mixed amalgam,'' which is what is actually used as the filling material placed in your teeth. Yes, that is correct. Although charged by law to evaluate and classify every medical or dental device to be used on or in humans, the FDA has not evaluated or classified ''mixed amalgam'' the material used in 75-80% of all tooth restorations. To avoid classifying mixed amalgam, the FDA simply took the position that mixed amalgam was a ''reaction'' product manufactured by the dentist when he or she mixed the mercury with the alloy before placing it in your tooth. Federal regulations allow dentists to assemble products, like the amalgam, that will be used solely in their professional practice. Because amalgam constituents (dental mercury and amalgam alloy) are substantially equivalent to devices that existed in interstate commerce prior to May 28, 1976 (the enactment date of the Medical Device Amendments) the Food and Drug Administration (FDA) permits them to be marketed under regulatory controls. This predication does not denote FDA approval of the amalgam or of its constituents. So the amalgam is truly an unregulated product that dentists assemble from two predicated devices. II) Paramount Scientific Documents The amalgam has two fundamental health flaws: 1) it has a sustained release of mercury and other toxic metals into the body, and 2) galvanic action produces electricity that flows through the body. Since pathophysiologic effects that toxicity has on the body can be objectively measured, scientific research pertaining to the amalgam's fundamental health flaws have been focused on the sustained mercury release. Abstracts to some of the more paramount scientific documents pertaining to pathophysiologic effects of the released mercury are presented below. II a) Review
SUMMARY: This document reviews results of animal and human studies of pathophysiologic effects related to mercury leaking from amalgam restorations. Some pertinent points presented include:
II b) Dental Mercury Impairs Kidney Function
ABSTRACT: In humans Hg vapor is released from "silver" amalgam fillings that contain 50% Hg by weight. Previous studies show that when 12 such fillings are placed in sheep teeth, the kidneys will concentrate amalgam Hg at levels ranging from 5 to 10 ug Hg/g renal tissue 4 to 20 weeks after placement. In the present study 12 occlusal fillings were placed in each of six adult female sheep under general anesthesia, using standard dental procedures. Glass ionomer occlusal fillings (12) were inserted in two control sheep. At several days before dental surgery, and at 30 and 60 days after placement of fillings, renal function was evaluated by plasma clearance of inulin and by plasma and urine electrolytes, urea, and proteins. An average plasma inulin clearance rate of 69.5 +/- 7.2 ml/min before amalgam placement was reduced to 32.3 +/- 8.1 ml/min by 30 days and remained low at 27.9 +/- 8.7 ml/min after 60 days. Inulin clearance did not change in controls. After amalgam placement urine concentration of albumin decreased from 93.0 +/- 20.5 to 30.1 +/- 15.3 mg/l and urine Na concentrations increased steadily from 24.8 +/- 7.7 to 82.2 +/- 20.3 mmol/l at 60 days. Concentrations of K, urea, Y-glutamyl transpeptidase, alkaline phosphatase, and total protein did not change significantly form 0 to 60 days in urine. Plasma levels of Na, K, urea, and albumin remained unchanged form 0 to 60 days after amalgam. Renal histology remained normal in amalgam-treated animals. It is concluded that amalgam Hg levels in kidney are sufficient to significantly reduce the rate of inulin clearance by non defined mechanisms and that electrolyte patterns in urine are consistent with impaired renal tubular reabsorption. II c) Dental Mercury Provokes an Increase in Oral and Intestinal Floras
ABSTRACT: In a survey of 640 human subjects, a subgroup of 356 persons without recent exposure to antibiotics demonstrated that those with a high prevalence of Hg resistance in their intestinal floras were significantly more likely to also have resistance to two or more antibiotics. This observation led us to consider the possibility that mercury released from amalgam ("silver") dental restorations might be a selective agent for both mercury- and antibiotic-resistant bacteria in the oral and intestinal floras of primates. Resistances to mercury and the several antibiotics were examined in the oral and intestinal floras of six adult monkeys prior the the installation of amalgam fillings, during the time they were in place, and after replacement of the amalgam fillings with glass ionomer fillings (in four of the monkeys). The monkeys were fed an antibiotic-free diet, and fecal mercury concentrations were monitored. There was a statistically significant increase in the incidence of mercury-resistant bacteria during the 5 weeks following installation of the amalgam fillings and during the 5 weeks immediately following their replacement with glass ionomer fillings. These peaks in incidence of mercury-resistant bacteria correlated with peaks of Hg elimination (as high as 1mM in the feces) immediately following amalgam placement and immediately after replacement of the amalgam fillings. Representative mercury-resistant isolates of three selected bacterial families (oral streptococci, members of the family Enterobacteriaceae, and enterocaocci) were also resistant to one or more antibiotics, including ampicillin, tetracycline, streptomycin, kanamycin, and chloramphenicol. While such mercury- and antibiotic-resistant isolates among the staphylococci, the enterococci, and members of the family Enterobacteriaceae, have been described, this is the first report of mercury resistance in the oral streptococci. Many of the enterobacterial strains were able to transfer mercury and antibiotic resistances together to laboratory bacterial recipients, suggesting that the loci for these resistances are genetically linked. Our findings indicate that mercury released from amalgam fillings can cause an enrichment of mercury resistance plasmids in the normal bacterial floras of primates. Many of these plasmids also carry antibiotic resistance, implicating the exposure to mercury from dental amalgams in an increased incidence of multiple antibiotic resistance plasmids in the normal floras of nonmedicated subjects. II d) Dental Amalgam Mercury in the Human Population II d1) Dental Mercury is Source of Two-Thirds of Mercury in Population
ABSTRACT: There is a considerable controversy as to whether dental amalgams may cause systemic health effects in humans because they liberate elemental mercury. Most such amalgams contain as much as 50% metallic mercury. To determine the influence of dental amalgams on the mercury body burden of humans, we have given volunteers, with and without amalgams in their mouth, the sodium salt of 2, 3-dimercaptopropane-1-sulfonic acid (DMPS), a chelating agent safely used in the Soviet Union and West Germany for a number of years. The diameters of dental amalgams of the subjects were determined to obtain the amalgam score. Administration of 300 mg DMPS by mouth increased the mean urinary mercury excretion of the amalgam group from 0.70 to 17.2 ug and that of the non amalgam group from 0.27 to 5.1 ug over a 9 hour period. Two-thirds of the mercury excreted in the urine of those with dental amalgams appears to be derived originally from the mercury vapor released from their amalgams. Linear regression analysis indicated a highly significant positive correlation between the mercury excreted in the urine 2 hours after DMPS administration and the dental amalgam scores. DMPS can be used to increase the urinary excretion of mercury and thus increase the significance and reliability of this measure of mercury exposure or burden, especially in cases of micromercurialism. II d2) Neurological Behavaioral Effects from Exposure to Dental Amalgam Mercury (focuses on dental personnel)
ABSTRACT: Potential toxicity from exposure to mercury vapor (Hg) from dental amalgam fillings is the subject of current public health debate in many countries. We evaluated potential central nervous system (CNS) toxicity associated with handling Hg-containing amalgam materials among dental personnel with very low levels of Hg exposure (i.e., urinary Hg < 4 ug/l), applying a neurobehavioral test battery to evaluate CNS functions in relation to both recent exposure and Hg body burden. New distinctions between subtle preclinical effects on symptoms, mood, motor function, and cognition were found associated with Hg body burden as compared with those associated with recent exposure. The pattern of results, comparable to findings previously reported among subjects with urinary Hg > 50 ug/l, presents convincing new evidence of adverse behavioral effects associated with low Hg exposures within the range of that received by the general population. II d3) Mobilization of Mercury and Arsenic in Humans by DMPS (including dental personnel)
Sodium 2, 3-dimercaptopropane-1-sulfonate (DMPS, Dimaval) is a water-soluble chelating agent that can be given by mouth or systemically and has been used to treat metal intoxication since the 1960's in the former Soviet Union and since 1978 in Germany. To better approximate the body burdens of Hg and As in humans, DMPS-Hg and DMPS-AS challenge tests have been developed. The tests involve collecting an overnight urine, administering 300 mg DMPS at zero time, collecting the urine from 0 to 6 hours, and determining the urinary Hg before and after DMPS is given. The challenge test, when applied to normal college student volunteers with and without amalgam restorations in their mouths, indicated that two-thirds of the Hg excreted in the urine after DMPS administration originated in their dental amalgams. In addition, there was a positive linear correlation between the amalgam score (a measure of amalgam surface) and urinary Hg after the challenge test. When the DMPS-Hg challenge test was used to study dental personnel occupationally exposed to Hg, the urinary excretion of Hg was 88, 49, and 35 times greater after DMPS administration than before administration in 10 dental technicians, 5 dentists, and 13 nondental personnel, respectively. DMPS also was used to measure the body burden of humans with a history of drinking water containing 600 ug As/liter. DMPS administration resulted in a tripling of the monomethylarsonic acid percentage and a halving of the dimethylarsinic acid percentage as related to total urinary As. Because South American animals studied were deficient in arsenite methytransferase, a hypothesis is presented that arsenite and arsenite methyltransferase may have had a role in the evolution of some South American animals. II e) Mercury Exposure via Breast Milk
ABSTRACT: Neonatal uptake of Hg from milk was examined in a pregnant sheep model, where radioactive mercury (Hg203)/silver tooth fillings (amalgam) were newly placed. A crossover experimental design was used in which lactating ewes nursed foster lambs. In a parallel study, the relationship between dental history and breast milk concentration of Hg was also examined. Results from the animal studies showed that, during pregnancy, a primary fetal site of amalgam, Hg concentration is in the liver, and after delivery the neonatal lamb kidney receives additional amalgam Hg from mother's milk. In lactating women with aged amalgam fillings, increased Hg excretion in breast milk and urine correlated with the number of fillings or Hg vapor concentration levels in mouth air. It was concluded that Hg originating from maternal amalgam tooth fillings transfers across the placenta to the fetus, across the mammary gland into milk ingested by the newborn and ultimately into neonatal body tissues. Comparisons are made to the U.S. minimal risk level recently established for adult Hg exposure. These findings suggest the placement and removal of "silver" tooth filings in pregnant and lactating humans will subject the fetus and neonate to unnecessary risk of Hg exposure. II f) Infertility
Heavy metals have been identified as factors affecting human fertility. This study was designed to investigate whether the urinary heavy metal excretion is associated with different factors of infertility. The urinary heavy metal excretion was determined in 501 infertile women after oral administration of the chelating agent 2,3-dimercaptopropane-1-sulfonic acid (DMPS). Furthermore, the influence of trace element and vitamin administration on metal excretion was investigated. Significant correlations were found between different heavy metals and clinical parameters (age, body mass index, nationality) as well as gynecological conditions (uterine fibroids, miscarriages, hormonal disorders). Diagnosis and reduction of an increased heavy metal body load improved the spontaneous conception chances of infertile women. The DMPS test was a useful and complementary diagnostic method. Adequate treatment provides successful alternatives to conventional hormonal therapy. IIg) Mercury Associated with Cardiac Dysfunction
OBJECTIVES: We sought to
investigate the possible pathogenetic role of myocardial trace elements (TE) in
patients with various forms of cardiac failure. III) Fetal Malformations
We ought not to set them aside with idle thoughts or idle words about "curiosities" or "chances." Not one of them is without meaning; not one that might not become the beginning of excellent knowledge, if only we could answer the question - why is it rare or being rare, why did it in this instance happen?
"...it is a sobering thought that after several decades of research, a number of international conferences and many other meetings, seminars and symposia, the problem of human malformations remains essentially unchanged." "...at least in the immediate future, it seems likely that the problem of human malformations will continue at about the present level (27 per every 1000 births)."
EXCERPTS: We have come to understand that chemicals in the environment can cause a wide range of develpmental disabilities in children, and that anatomic malformations are only the most obvious. Current concerns especially focus on the concept that certain chemicals can cause clinical and subclinical deficits in neurobehavioral development through injury to the fetal brain. The implications of small shifts in intelligence quotient score and a slighlty increased tendency to aggression are not so easilly conveyed or grasped as a picture of deformed limbs. However, recognition of the importance of such changes is gathering momentum and is documented in this monograph. A prime motivating force is the realization that we know the cause of fewer than 25% of neurodevelopmental disabilities. These disabilities including dyslexia, attention deficit hyperactivity disorder (ADHD), intellectual retardation, and autism, affect an estimated 3 to 8% of the 4 million babies born each year in the United States. For most neurodevelopmental disabilities, the cause remains unknown. A diverse assortment of toxic chemicals in the environment is capable of causing neurodevelopmental disabilities. Organic mercury compounds are among the most potent developmental neurotoxicants. In the words of pediatrician Herbert L. Needleman: "We are conductiong a vast toxicologic experiment in our society in which our children and our children's children are the experimental subjects." The American Academy of Pediatrics has just publiched its Handbook of Pediatric Environmental Health, the "Green Book," which is available to pediatricians throughout the Americas. Children's environmental health has climbed to a critical position as we launch the new millennium. This monograph marks a significant milestone in the evolution of this emerging discipline. When dental mercury crosses over the placenta into the tissue of the developing fetus, does it cause fetal malformations? These studies answer that question. III a) Sheep Study
ABSTRACT: In humans, the continuous release of Hg vapor from dental amalgam tooth restorations is markedly increased for prolonged periods after chewing. The present study establishes a time-course distribution for amalgam, Hg in body tissues of adult and fetal sheep. Under general anesthesia, five pregnant ewes had twelve occlusal amalgam fillings containing radioactive 203Hg placed in teeth at 112 days gestation. Blood, amniotic fluid, feces, and urine specimens were collected at 1- to 3-day intervals for 16 days. From days 16-140 after amalgam placement (16-41 days for fetal lambs), tissue specimens were analyzed for radioactivity, and total Hg concentrations were calculated. Results demonstrate that Hg from dental amalgam will appear in maternal and fetal blood and amniotic fluid within 2 days after placement of amalgam tooth restorations. Excretion of some of this Hg will also commence within 2 days. All tissues examined displayed Hg accumulation. Highest concentrations of Hg from amalgam in the adult occurred in kidney and liver, whereas in the fetus the highest amalgam Hg concentrations appeared in the liver and pituitary glands. The placenta progressively concentrated Hg as gestation advanced to term, and milk concentration of amalgam Hg postpartum provides a potential source of Hg exposure to the newborn. It is concluded that accumulation of amalgam Hg progresses in maternal and fetal tissues to a steady state with advancing gestation and is maintained. III b) Rat Studies
ABSTRACT: Pregnant rats were either 1) administered methyl mercury (MeHg) by gavage, 2 mg/kg/day during days 6-9 of gestation, 2) exposed by inhalation to metallic mercury (Hg) vapor (1.8 mg/m3 air for 1.5 hours per day) during gestation days 14-19, 3) exposed to both MeHg by gavage and Hg vapor by inhalation (MeHg + Hg), or 4) were given combined vehicle administration for each of the two treatments (control). The inhalation regimen corresponded to an approximate dose of 0.1 mg Hg/kg/day. Clinical observations and developmental markers up to weaning showed no differences between any of the groups. Testing of behavioral functions was performed between 4 and 5 months of age and included spontaneous motor activity, spatial learning in a circular path, and instrumental maze learning for food reward. Offspring of dams exposed to Hg vapor showed hyperactivity in the motor activity test chambers over all three parameters: locomotion, rearing and total activity; this effect was potentiated in the animals of the MeHg + Hg group. In the swim maze test, the MeHg + Hg and Hg groups evidenced longer latencies to reach a submerged platform, which they had learned to mount the day before, compared to either the control or MeHg group. In the modified, enclosed radial arm maze, both the MeHg + Hg and Hg groups showed more ambulations and rearings in the activity test prior to the learning test. During the learning trial, the same groups (i.e., MeHg + Hg and Hg) showed longer latencies and made more errors in acquiring all eight pellets. Generally, the results indicate that prenatal exposure to Hg causes alterations to both spontaneous and learned behaviors, suggesting some deficit in adaptive functions. Coexposure to MeHg, which by itself did not alter their functions at the dose given in this study, served to significantly aggravate the change.
ABSTRACT: The effects of mercury vapour on the production of nerve growth factor during development have been examined. Pregnant rats were exposed to two different concentrations of mercury vapour during either embryonic days E6-E11 (early) or E13-E18 (late) in pregnancy, increasing the postnatal concentration of mercury in the brain from 1 ng/g tissue to 4 ng/g tissue (low-dose group) or 11 ng/g (high-dose group). The effect of this exposure in offspring was determined by looking at the NGF concentration at postnatal days 21 and 60 and comparing these levels to age-matched controls from sham-treated mothers. Changes in the expression of mRNA encoding NGF, the low- and high-affinity receptors for NGF (p75 and p140 trk. respectively) and choline acetyltransferase (ChAT) were also determined. When rats were exposed to high levels of mercury vapour during early embryonic development there was a significant (62%) increase in hippocampal NGF levels at P21 accompanied by a 50% decrease of NGF in the basal forebrain. The expression of NGF mRA was found to be unaltered in the dentate gyrus. The expression of p75 mRNA was significantly decreased to 39% of control levels in the diagonal band of Broca (DB) and to approximately 50% in the medial septal nucleus (MS) whereas no alterations in the level of trk mRNA expression were detectable in the basal forebrain. ChAT mRNA was slightly decreased in the DB and MS, significantly in the striatum. These findings suggest that low levels of prenatal mercury vapour exposure can alter the levels of the NGF and its receptors, indicating neuronal damage and disturbed trophic regulations during development.
ABSTRACT: Brain metallothionein (MT) protein and mRNA levels were determined in the fetal rat following in utero (gestational days 7-21) exposure to elemental mercury vapor (Hg0; 300 microg Hg/m3; 4 h/day). Total RNA was probed on Northern blots with [alpha-32P]dCTP-labeled synthetic cDNA probes specific for rat MT isoform mRNAs. The probes for MT-I and MT-II mRNA hybridized to a single band of approximately 550 and 450 nucleotides, respectively. Expression of whole brain MT-I mRNA in full-term fetal rats (day 21) was significantly increased (P < 0.03) by in utero exposure to Hg0 compared to nonexposed controls. This corresponded to a 14-fold increase (P < 0.001) in fetal brain Hg concentration after in utero Hg0 exposure. In addition, astrocytes from both control and in utero Hg0-exposed fetuses were isolated, and neonatal primary astrocyte cultures were established and maintained in vitro for up to 3 weeks without additional experimental intervention. Astrocyte monolayers derived from in utero Hg0-exposed fetuses consistently expressed increased abundance of MT-I mRNA transcripts after 1, 2, and 3 weeks in culture (P < 0.03, P < 0.01, and P < 0.03, respectively) compared with controls. The abundance of astrocyte MT-II mRNA was unchanged at 1 and 2 weeks in culture, but was significantly increased at 3 weeks in cultures derived from brains of Hg0-exposed fetuses (P < 0.04). Consistent with the increase in MT mRNA, an increase in astrocytic levels of MT proteins was noted by Western blot analysis and MT-immunoreactivity. These studies suggest that in utero exposure to Hg0 induces brain MT gene expression, and that MT mRNAs and their respective proteins are useful quantitative biochemical markers of intrauterine exposure to Hg0, a potentially cytotoxic challenge to astrocytes in the developing brain. It is concluded that induction of MT by fetal/neonatal astrocytes represents an attempt by these glial cells to protect against Hg cytotoxicity in maintaining cerebral homeostasis.
III c) Human Study
ABSTRACT: The total mercury concentrations in the liver (Hg-L), the kidney cortex (Hg-K) and the cerebral cortex (Hg-C) of 108 children aged 1 day- 5 years, and the Hg-K and Hg-L of 46 fetuses were determined. As far as possible, the mothers were interviewed and their dental status was recorded. The results were compared to mercury concentrations in the tissues of adults for the same geographical area. The Hg-K (n=38) and Hg-L (n=40) of fetuses and Hg-K (n=35) and Hg-C (n=35) of older infants (11-50 weeks of life) correlated significantly with the number of dental amalgam fillings of the mother. The toxicological relevance of the unexpected high Hg-K of older infants from mother with higher numbers of dental amalgam fillings is discussed. Conclusion: Future discussion on the pros and cons of dental amalgam should not be limited to adults or children with their own amalgam fillings, but also include fetal exposure. The unrestricted application of amalgam for dental restorations in women before and during the child-bearing age should be reconsidered. Abbreviations: Hg-C total mercury concentration in the cerebral cortex (ng/g wet weight). Hg-K total mercury concentration in the renal cortex (ng/g wet weight). Hg-L total mercury concentration in the liver (ng/g wet weight).
This paper presents benchmark (BMD) calculations and additional regression analyses of data from a study in which scores from 26 scholastic and psychological tests administered to 237 6- and 7- year old New Zealand children were correlated with the mercury concentration in their mothers' hair during pregnancy. The original analyses of five test scores found an association between high prenatal mercury exposure and decreased test performance, using category variables for mercury exposure. Our regression analyses, which utilized the actural hair mercury level did not find significant associations between mercury and children's test scores. However, this finding was highly influenced by a single child whose mother's mercury hair level (86 mg/kg) was more thatn four times that of any other mother. When that child was ommited, results were more indicative of a mercury effect and scores on six tests were significantly associated with the mothers' hair mercury level. BMDs calculated from five tests ranged from 32 to 73 mg/kg hair mercury, and corresponding BMDs (95% lower limits on BMDs) ranged form 17 to 24 mg/kg. When the child with the highest mercury level was omitted, BMDs ranged from 13 to 21 mg/kg, and corresponding BMDLs ranged from 7.4 to 10 mg/kg. IV) Alzheimer's Disease Studies Many on-going studies have linked many aspects of amalgam mercury to brain tissue damage found in patients with Alzheimer's Disease. Abstracts from these on-going studies are presented below. IV a) Trace Elements in Alzheimer's Disease Brains
ABSTRACT: Concentrations of 13 trace elements (Ag, Br, Co, Cr, Cs, Fe, Hg, K, Na, Rb, Sc, Se, Zn) in isolated subcellular fractions (whole brain, nuclei, mitochondria, microsomes) of temporal lobe from autopsied Alzheimer's disease (AD) patients and normal controls were determined utilizing instrumental neutron activation analysis. Comparison of AD and controls revealed elevated Br (whole brain) and Hg (microsomes) and diminished Rb (whole brain, nuclear and microsomes), Se (microsomes) and Zn (nuclear) in AD. The elevated Br and Hg and diminished Rb are consistent with our previous studies in AD bulk brain specimens. Comparison of element ratios revealed increased Hg/Se, Hg/Zn and Zn/Se mass ratios in AD. Se and Zn play a protective role against Hg toxicity and our data suggest that they are utilized to detoxify Hg in the AD brain. Overall our studies suggest that Hg could be and important toxic element in AD. Whether Hg deposition in AD is a primary or secondary event remains to be determined.
ABSTRACT: Cerebro-spinal fluid (CSF) and blood levels of aluminum, cadmium, calcium, copper, lead, magnesium, and mercury were studied in 24 subjects with dementia of the Alzheimer type (DAT) and in 28 healthy volunteers. Furthermore, arsenic, bromine, chrome, iron, manganese, nickel, rubidium, selenium, strontium, and zinc were measured only in blood. There were significant changes in the DAT group when compared to the controls. The plasma levels of aluminum, cadmium, mercury and selenium were increased and the contents of iron and manganese were lower in the DAT group as compared to control subjects. In CSF there were low levels of cadmium and calcium and increased content of copper in DAT cases. Iron and zinc levels in blood and calcium in both blood and CSF of DAT patients correlated with memory and cognitive functions. Iron, manganese and strontium levels of DAT sufferers in blood and aluminum in CSF were related with changes in behavior.
ABSTRACT: Four elements that have been implicated in free radical induced oxidative stress in Alzheimer's Disease (AD) were measured by instrumental neutron activation analysis (INAA) in seven brain regions from 58 AD patients and 21 control subjects. A statistically significant elevation of iron and zinc was observed in multiple regions of AD brain, compared with controls. Mercury was elevated in AD in most regions studied, but the high variability of mercury levels in both AD and control subjects prevented the AD-control difference from reaching significance. Selenium, a protective agent against mercury toxicity, was significantly elevated only in AD amygdala. The elevation of iron and zinc in AD brain has the potential of augmenting neuron degeneration through free radical processes. IV b) Mercury Vapor Inhalation Inhibits Tubulin in Rat Brain
ABSTRACT: Mercury (Hg) interacts with brain tubulin and disassembles microtubules that maintain neurite structure. Since it is well known that Hg vapor is continuously released from "silver" amalgam tooth fillings and is absorbed into brain, rats were exposed to Hg 4 hr/day for 0, 2, 7, 14, and 28 days at 250 or 300 mcg Hg/m3 air, concentrations present in mouth air of some humans with many amalgam fillings. Average rat brain Hg concentrations increased significantly (11-47 fold) with duration of Hg exposure. By 14 days of Hg exposure, photoaffinity labeling of the B-subunit of the tubulin dimer with (a32P)8N3GTP in brain hamogenates was decreased 41-74% , upon analysis of SDS-PAGE autoradiograms. The identical neurochemical lesion of similar or greater magnitude is evident in Alzheimer brain homogenates from approximately 80% of patients, when compared to human age-matched controls. Since the rate of tubulin polymerization is dependent upon binding of GTP to tubulin dimers, we conclude that chronic inhalation of low-level Hg can inhibit polymerization of tubulin essential for formation of microtubules. IV c) HgEDTA Complex Inhibits Tubulin
We have found that EDTA and EGTA complexes of Hg2+, which conventional wisdom has assumed are biologically inert, are potentially injurious to the neuronal cytoskeleton. Tubulin, a major protein component of the neuronal cytoskeleton, is the target of multiple toxicants, including many heavy metal ions. Among the mercurials, inorganic mercuric ion (HG2+) is one of the most potent inhibitors of microtubule polymerization both in vivo and in vitro. In contrast to other heavy metals, the capacity of Hg2+ to inhibit microtubule polymerization or disrupt formed microtubules cannot be prevented by the addition of EDTA and EGTA, both of which bind Hg2+ with very high affinity. To the contrary, the addition of these two chelating agents potentiates Hg2+ inhibitiion of tubulin polymerization. Results herein show that HgEDTA and HgEGTA inhibit tubulin polymerization by disrupting the interaction of GTP with the E-site of brain B-tubulin, an obligatory step in the polymerization of tubulin. Both HgEDTA and HgEGTA, but not free Hg2+, prevented binding of (32P)8N3GTP, a photoaffinity nucleotide analog of GTP, to the E-site and displaced bound (32P)8N3GTP at low micromolar concentrations. This complete inhibition of photoinsertion into the E-site occured in a concentration and time dependent fashion and was specific for Hg2+ complexes of EDTA and EGTA, among the chelating agents tested. Given the ubiquity of Hg2+ in the environment and the widespread use of EDTA in foodstuffs and medicine, these mercury complexes may pose a potentially serious threat to human health and play a role in diseases of the neuronal cytoskeleton. IV d) Increased Blood Mercury Levels in Patients with Alzheimer's Disease
SUMMARY: Alzheimer's disease
(AD) is a common neurodegenerative disorder that leads to dementia and death. In
addition to several genetic parameters, various environmental factors may
influence the risk of getting AD. In order to test whether blood levels of the
heavy metal mercury are increased in AD, we measured blood mercury
concentrations in AD patients (n=33), and compared them to age-matched control
patients with major depression (MD) (n=45), as well as to an additional control
group of patients with various non psychiatric disorders (n=65). Blood mercury
levels were more than two fold higher in AD patients as compared to both control
groups (p=0.0005, and p=0.0000, respectively). In early onset AD patients
(n=13), blood mercury levels were almost three fold higher as compared to
controls (p=0.0002, and p=0.0000, respectively). These increases were unrelated
to the patients' dental status. Linear regression analysis of blood mercury
concentrations and CSF levels of amyloid B-peptide (AB) revealed a significant
correlation of these measures in AD patients (n=15, r=0.7440, p=0.0015, Pearson
type of correlation). These results demonstrate elevated blood levels of mercury
in AD, and they suggest that this increase of mercury levels is associated with
high CSF levels of AB, whereas tau levels were unrelated. Possible explanations
of increased blood mercury levels in AD include yet unidentified enviromental
sources or release from brain tissue with the advance in neuronal death. IVe) Mercury Induces Cell Cytotoxicity and Oxidative Stress and Increases ß-Amyloid Secretion and Tau Phosphorylation in SHSY5Y Neuroblastoma Cells
ABSTRACT: Concentrations of heavy metals, including mercury, have been shown to be altered in the brain and body fluids of Alzheimer's disease (AD) patients. To explore potential pathophysiological mechanisms we used an in vitro model system (SHSY5Y neuroblastoma cells) and investigated the effects of inorganic mercury (HgCl2) on oxidative stress, cell cytotoxicity, ß-amyloid production, and tau phosphorylation. We demonstrated that exposure of cells to 50 µg/L (180 nM) HgCl2 for 30 min induces a 30% reduction in cellular glutathione (GSH) levels (n = 13, p < 0.001). Preincubation of cells for 30 min with 1 µM melatonin or premixing melatonin and HgCl2 appeared to protect cells from the mercury-induced GSH loss. Similarly, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assays revealed that 50 µg/L HgCl2 for 24 h produced a 50% inhibition of MTT reduction (n = 9, p < 0.001). Again, melatonin preincubation protected cells from the deleterious effects of mercury, resulting in MTT reduction equaling control levels. The release of ß-amyloid peptide (Aß) 1-40 and 1-42 into cell culture supernatants after exposure to HgCl2 was shown to be different: Aß 1-40 showed maximal (15.3 ng/ml) release after 4 h, whereas Aß 1-42 showed maximal (9.3 ng/ml) release after 6 h of exposure to mercury compared with untreated controls (n = 9, p < 0.001). Preincubation of cells with melatonin resulted in an attenuation of Aß 1-40 and Aß 1-42 release. Tau phosphorylation was significantly increased in the presence of mercury (n = 9, p < 0.001), whereas melatonin preincubation reduced the phosphorylation to control values. These results indicate that mercury may play a role in pathophysiological mechanisms of AD. IV f) Retrograde degeneration of neurite membrane structural integrity of nerve growth cones following in vitro exposure to mercury.
Inhalation of mercury vapor (Hg0)
inhibits binding of GTP to rat brain tubulin, thereby inhibiting
V) Amalgam Removal V a) Patient Preparation for Amalgam Removal AMALGAM REMOVAL PREPARATION WARNING: When the body is exposed to amalgam mercury it has an on-going need for detoxification and healing processes. If you have a medical condition, then hormones and enzymes the body needs to heal have likely been depleted by this on-going detoxification and healing process. So before your amalgam restorations are removed, blood testing should be performed to determined what hormones and enzymes are deficient. Based on the blood test results a medical doctor can evaluate what nutritional and hormonal supplements are needed to prepare the body. After amalgams are removed, the healing usually accelerates, so there will be an even greater demand for the hormones and enzymes that were depleted. So a patient with a medical condition should take nutritional and hormonal supplements before, during and after amalgam removal. V b) Dental Procedures for Patient Protection During Amalgam Removal
The IAOMT has currently established the following amalgam removal protocols. If these protocols are followed, the amount of mercury released into the body during amalgam removal is reduced.
Other amalgam removal precautions in addition to the protocols listed above include:
Further information pertaining to proper amalgam removal can be found on the web page http://www.holisticmed.com/dental/amalgam/iaomt.txt. V c) Amalgam Removal without Patient Protection This study measures the mercury level when amalgams are removed not following the protocols presented above.
ABSTRACT: In 10 healthy persons all amalgam fillings were replaced with gold inlays. Blood and urinary levels were measured on 10 occasions during a 4-month period before and a 12-month period after amalgam removal. These variables were also measured three times in 10 healthy controls. A strong statistically significant relation was found between plasma mercury values and both the total number of amalgam surfaces (r=0.71, p=0.0006) and the total surface area of the fillings (r=0.73, p=0.004). In the immediate post removal phase plasma mercury rose three- to four-fold, whereas the urinary and erythrocyte mercury rose about 50%. These peak values declined to the pre-removal level at about 1 month after removal. Twelve months after the removal plasma and urinary mercury levels were reduced to 50% and 25%, respectively, of the initial values for the experimental group. Apart from the significantly lower plasma selenium values 5 and 10 days after removal no significant differences were found with regard to plasma selenium or erythrocyte glutathione peroxidase either within or between the experimental and the control groups. A large number of supplementary biochemical analyses did not show any influence on organ functions or any differences between the groups before or after the amalgam removal. Amalgam fillings considerably contributed to the plasma and urinary mercury levels. V d) Amalgam Removal with Patient Protection This study measures the mercury level when amalgams are removed following the IAOMT protocols presented above.
ABSTRACT: Even through a number of studies have not been able to reveal any correlation between subjective symptoms and amalgam load there still are speculations whether patients with subjective symptoms related by the patients themselves to their amalgam fillings could have a changed pattern of elimination of mercury. The aim of the present investigation was to study the elimination half-time of mercury in plasma, erythrocytes and urine over an extended period of time after amalgam removal in a group of 10 patients with subjective symptoms by the patients themselves referred to their amalgam fillings and a group of 8 healthy subjects. The average number of occlusal and total amalgam surfaces in the patient group were 13.0 (range 4-20) and 44.4 (range 24-68), respectively. Corresponding figures in the control group were 12.9 (range 10-16) and 40.9 (range 24-63). The amalgam removal using rubber dam, water spray cutting and high volume vacuum evacuator, was carried out at one and the same time. Blood and urine samples were collected at two occasions before the amalgam removal, then blood was collected at thirty two occasions and urine at forty three occasions during the following year. The mercury content was analyzed by CVAAS technique. The measured P-, Ery- and U-Hg concentrations before amalgam removal were slightly higher in the control group 6.43.3 nmol/L, 19.46.6 nmol/L, and 2.71.3 nmol/nmol creatinine respectively than in the symptom group 5.61.8 nmol/L, 14.88.8 nmol/L, and 1.60.9 nmol/nmol creatinine respectively. The Hg-concentrations did not significantly increase in the two groups after amalgam removal. Six days after the removal the plasma mean concentration was significantly decreased at P level and ten days after the decrease was at a permanent P level. The mean Ery-Hg level was significantly decreased after eleven days (p), a level that remained stable for the rest of the year. The mean U-Hg level was significantly decreased one month after the removal and after six months the mean level was reduced with 80 % compared to the initial level in both groups. The conclusion to be drawn for the present study is that the symptom group did not have a changed pattern of elimination of mercury compared to the healthy group.
ABSTRACT: The long-term urinary mercury excretion was determined in seventeen 28- to 55-year old persons before and at varying times (up to 14 months) after removal of all (4-24) dental amalgam fillings. Before removal the urinary mercury excretion correleated with the number of amalgam fillings. In the immediate post-removal phase (up to 6 days after removal) a mean increase of 30 percent was observed. Within 12 months the geometric mean of the mercury excretion was reduced by a factor of five from 1.44ug/g (range: 0.57 to 4.38ug/g) to 0.35 ug/g (range: 0.13 to 0.88 ug/g). After cessation of exposure to dental amalgam contributes predominatly to the mercury exposure of non-occupationally exposed persons. The exposure from amalgam fillings thus exceeds the exposure form food, air and beverages. Within 12 months after removal of all amalgam fillings the participants showed substantially lower urinary mercury levels which were comparable to those found in subjects who have never had dental amalgam fillings. A relationship between the urinary mercury excretion and adverse effects was not found. Differences in the frequency of effects between the pre- and post-removal phase were not observed. DISCUSSION: The initial
urinary mercury concentations (before amalgam removal) were similar to those
found in previous studies in people with amalgam fillings while the final values
(12 months of ter amalgam removal) were comparable to those for people who have
never had amalgam fillings. V e) Pregnancy Precaution The formation of a fetus is very much at risk to mercury in its mother's blood, so the continuous release of mercury from amalgam restorations may be responsible for a portion of the birth defects seen in our society today. When an amalgam filling is removed or an amalgam-filled tooth is extracted, a surge of mercury may be released into the bloodstream. Women should have their amalgam fillings removed at least one year in advance of when they intend to become pregnant and discuss the risk with an informed medical doctor or dentist. Women should never have amalgam fillings removed during a pregnancy. V f) Patient Reports
SUMMARY: A Utah dentist provided the names and addresses of approximately 300 people who had their amalgams removed. A health questionnaire was sent to these people; 86 subjects responded. Eighty (80) % of the subjects reported that they felt better following amalgam removal. Nearly all of the subjects 91% said they were glad their amalgams had been removed and 88% said they would do it again. An increase in happiness and peace of mind was experienced by 58% of the subjects. This evidence suggests that the well being of these subjects improved immensely after amalgam removal.
SUMMARY: This book presents patient-reported case histories, where they associate their health problems to dental amalgam mercury. Case histories include: Chronic Fatigue Syndrome, Seizures, Memory Loss, Migraines, Multiple Allergies, Multiple Sclerosis, Depression, Lupus, Maldigestion, Chemical Sensitivities, Insomnia, Miscarriages, Paralysis, Sinus Problems, Emotional & Mental Disorders, Infertility, Endometriosis, Crohn's Disease, Rashes, Anxiety, Tremors & Spasms, Amyotrophic Lateral Sclerosis, Universal Reactor and many others....... V g) Chronic Disease a Big Financial Burden, and Growing
Nearly half of Americans suffer at
least one chronic disease, everything from allergies to heart And they warn that the fast-growing toll, now at 125 million among a population of 276 million, will reach 157 million by 2020. One-fifth of Americans have two or more chronic illnesses, complicating their care and making it more expensive. The nation is unprepared to cope with the growing burden of chronic disease, with annual medical bills alone expected to almost double to $1.07 trillion by 2020. It's the major public health challenge that could affect all Americans. While doctors have made major advances in treating certain chronic illnesses, they cause 70 percent of all U.S. deaths, reports the federal Center for Disease Control and Prevention, which convened the meeting to explore ways to better prevent and fight long-term illness. It's a difficult subject partly because so many different diseases qualify. Simple allergies may not kill someone, but require a lifetime of medication and doctor visits. Heart disease can require even more complex drug therapy, surgery and testing. At the other extreme is Alzheimer's disease, eventually requiring round-the-clock care. Preventive care - weight management, disease screening, nutrition, exercise, geriatric assessments for the elderly - can stave off many chronic diseases. But it takes longer than writing a prescription, and few insurers reimburse fully. An overweight, diabetic farmer has insurance to pay for a 20-minute physicians office visit, just enough time to have his blood sugar tested so an adjustment to the medication can be made. The physician says helping the man lose weight would do more good, but he is not paid to recommend that. Already 60 million Americans suffer multiple chronic illnesses, a number expected to reach 81 million by 2020 as the population ages. Someone without a chronic illness pays an average of $182 a year in out-of-pocket health expenses, compared with $369 in out-of-pocket payments by patients with one chronic illness and $1,106 for someone battling three or more. Total annual health costs for someone with one chronic illness are more than five times higher than for a healthy person - $6,032 vs. $1,105 - and rise even higher the more disabling the chronic illness. VI) Dental Mercury a Source of Air and Water Pollution A report released on December 19, 1997 titled "Mercury Study Report to Congress" by the Environmental Protection Agency has estimated that human caused emissions of mercury in the U.S. total 158 tons. The researchers estimated 33 percent of that 158 tons comes from coal-fired utility boilers, 19 percent from municipal incinerators, 18 percent from industrial boilers, and 10 percent from medical incinerators. The EPA researchers apparently were unaware of another pollution source: dental mercury. Each year in the U.S. an estimated 40 tons of mercury are used to prepare mercury-amalgam dental restorations. Scientific studies have concluded that the amalgam is the source for more than two thirds of the mercury in our human population. Each amalgam, which is commonly called a "silver filling" by its installers, daily releases on the order of 10 micrograms of mercury into the body. This mercury either accumulates in the body or gets excreted via urine and feces into our wastewater systems. After a person dies, the mercury that has accumulated in the body is released to the environment via either cremation or burial. Another source of mercury pollution is dental office disposal. Most dental offices without a metal separator dispose of their waste mercury into municipal wastewater systems. Municipal treatment plant processing separates wastewater into water and sludge. Mercury does not disappear during this processing. Both treated water that is discharged into waterways and sludge that is land-farmed contain mercury. Mercury is also contained in air discharged from dental offices into the atmosphere. The wastewater, sludge and dental office air are another source of mercury pollution. VIa) Mercury in Dental Clinic Wastewater Discharge This study measures the level of mercury discharged to the public waste water systems by dental offices.
ABSTRACT: Data was obtained on the amount of Hg discharged with the wastewater from dental clinics. Waste water from 20 Danish dental clinics was collected during one working day and analyzed for the amount of Hg using the technique of cold vapor atomic absorption spectrophotometry (CVAAS). From clinics without amalgam separator mean value was 270 mg Hg per dentist per day (range 65 to 842), from clinics equipped with amalgam separator mean value was 35 mg Hg per dentist per day (range 12 to 99). It was concluded that Hg is released with the waste water from dental clinics. Several hundred grams of Hg per clinic may be discharged annually with the waste water. Installation of efficient amalgam separators may reduce the Hg outlet markedly. COMMENT: Very few dental offices in the United States have amalgam separators. Taking the mean daily level of 270 milligrams times 200 (working) days per year yields an annual value of 54 grams of Hg per dental office per year. Utilizing a conservative figure of 100,000 dental offices in the United States, a total of 5400 kilograms (12,172 pounds) of mercury exits U.S. dental offices in waste water each year. VII) American Dental Association's Position The American Dental Association has taken the following positions about "the dental amalgam issue." VII a) Journal of the American Dental Association
The strongest and most convincing support we have for the safety of dental amalgam is the fact that each year more than 100 million amalgam fillings are placed in the United States. And since amalgam has been used for more than 150 years, literally billions of amalgam fillings have been successfully used to restore decayed teeth. VII b) Superior Court Demurrer
The American Dental Association (ADA) owes no legal duty of care to protect the public form allegedly dangerous products used by dentists. The ADA did not manufacture, design, supply or install the mercury-containing amalgams. The ADA does not control those who do. The ADA's only alleged involvement in the product was to provide information regarding its use. Dissemination of information relating to the practice of dentistry does not create a duty of care to protect the public from potential injury. VII c) ADA's Code of Ethics The American Dental Association's (ADA) code of ethics makes the removal of serviceable mercury amalgam restorations an issue of ethical conduct. In the ADA's point of view, it is ethical for a dentist to place mercury amalgam restorations in a patient and claim their safety. However, according to the ADA's code of ethics a dentist who acknowledges that mercury amalgam restorations are toxic and recommends their removal has acted unethically ("...the removal of amalgam restorations from the non-allergic patient for the alleged purpose of removing toxic substances from the body when such treatment is performed solely at the recommendation of the dentist is improper and unethical...." ADA Resolution 42H-1986. Transaction 1986:536) On the basis of the ADA's code of ethics, state dental boards have taken disciplinary action against mercury-free dentists who have practiced their profession in accordance with current scientific knowledge and their conscience. The disciplinary action has ranged from restrictions placed on their practice to the loss of license. VII d) ADA's Internet Site Additional information about the ADA's position on the dental amalgam issue can be found on the web page: http://www.ada.org/topics/amalgam.html VIII) Composite Restoration Material An alternative to the mercury dental amalgam is composite restoration material. Composite restoration material has a white appearance.
ABSTRACT: Concerns have been expressed regarding the health risks posed by chemical exposures from dental restorative materials. Dental materials are exempted from the pre-market review provisions for medical devices in Canada; therefore, information on the risks of potential chemical exposures arising from such material is lacking. An assessment of components and degradation products of the class of dental materials known as composite resins was undertaken to provide such chemical exposure and risk information. A probabilistic assessment was undertaken of adult exposures to two principal components of composite resins - silica, bisphenol-A glycidylmethacraylate (BIS-GMA) and two degradation products of BIS-GMA; formaldehyde and methacrylic acid. Assuming that the Canadiam adult population with fillings had only composite resin materials, results indicated that average exposures to formaldehyde and methacrylic acid were 10,000 times and 1,600,000 times lower, respectively, than relevant reference doses. Worst case exposures were also well below applicable reference levels. Risks posed by exposures to BIS-GMA and silca could not be assessed due to a lack of published ingestion reference doses for these substances. Gaps in the data base relating to the risks posed by composite resin dental materials were discussed, particlularly in reference to the recently reported estrogenic postential of other degradation products of BIS-GMA. IX) State Statute IX a) Colorado Statute Nothing in this section shall be construed to deprive any dental patients of the right to choose or replace any professionally recognized restorative material, nor to permit disciplinary action against a dentist solely for removing or placing any professionally recognized restorative material. IX b)
IX c) X) Amalgam Lawsuit
After considering evidence and
extensive arguments from attorneys for the plaintiff and defendants, the judge
in the California case of Tolhurst vs. Johnson & Johnson Consumer Products, Inc.
ruled that it is not generally accepted in the scientific community that mercury
from amalgam dental fillings is capable of causing Guillain Barre' Syndrome, the
affliction allegedly suffered by plaintiff Tolhurst. The judge therefore
suppressed any evidence at the trial demonstrating that mercury was the cause of
the plaintiff's illness. The evidentiary hearing was held in response to a
defense motion based on the Frye rule. This rule requires a plaintiff to
demonstrate that the scientific tests, techniques, and methods on which he/she
intends to rely at trial are "sufficiently established to have gained general
acceptance in the particular field in which it belongs." The test emphasizes a
comparison of the members of the relevant scientific community who do or do not
consider the proposed scientific test, method, or technique as valid and
reliable.
The potential for harmful health effects resulting from mercury exposure from mercury/silver amalgam dental fillings is no longer a matter of scientific debate. Such adverse effects have now been documented and reported by qualified medical scientists. Serious questions exist regarding mercury's role in loss of kidney function, Alzheimer's Disease, and a host of neurological disorders. My client, the International Academy of Oral Medicine and Toxicology (IAOMT) has compiled and reviewed all relevant scientific documentation and has found a total lack of scientific rigor to support statements that chronic exposure to mercury from dental amalgam is harmless to patients. I am sure you and your attorneys are all too aware of the potential for product liability under Restatement of Torts, Section 402A and other relevant law. In view of the totality of the information that is now available, not only does it seem likely that there will be an avalanche of product liability in the future, but that for those companies which continue to market the product, there will be a real potential for the assessment of punitive damages, much as we have seen against the asbestos industry. We believe it in your company's best interest, as well as in the interest of public health, that all use of mercury as a dental filling material cease immediately. The IAOMT has more specific information if you desire. The above letter was sent to the following amalgam manufactures:
XII) Government Phase Outs In the interest of protecting their citizens' health, Sweden, Norway, Germany, Denmark, Austria, Finland and Canada have recently taken steps to limit and phase out the use of amalgam restorations. The United States of America Food and Drug Administration has not recently reviewed the safety of amalgam restorations. XIII) Organizations
"DAMS Inc. (Dental Amalgam Mercury Syndrome) is a grassroots organization dedicated to educating the public about the health hazards associated with mercury that leaks from amalgam dental restorations, which are known as "silver fillings. There is a growing body of scientific documentation that indicates the mercury leaking out of amalgams is insidiously dangerous to a person's health. Many of our people have had recoveries from serious health problems, which were considered to have an unknown cause and cure, after their amalgams were removed and replaced with non-toxic restorative material. So we feel a calling to educate the public about health hazards associated with the dental amalgam. We are all volunteers. A basic information packet is available from DAMS. A 7$ donation to DAMS is requested for the information packet. Contact: DAMS, Inc.
If you are a mercury-free dentist or are contemplating going mercury-free, you need to join the IAOMT. The IAOMT has helped fund or has been the catalyst for much of the current scientific research demonstrating that dental amalgam is not the benign dental material that 150 years of use and the ADA would like you to believe. Furthermore, the IAOMT is doing something about Standards of Care and Protocols that protect you, your staff and the patient. For membership contact: IAOMT
The Holistic Dental Association is dedicated to expanding the clinical skills of conscientious dentists for the year 2000 and beyond. They have a dentist referral service.
An association of doctors who practice alternative or complementary medicine. Most of them also practice chelation therapy, which is used to detoxify the body. ACAM
The American Academy of Environmental Medicine is dedicated to the purpose of recognition, treatment and prevention of illness induced by exposures to biological and chemical agents encountered in air, food, and water. AAEM members recognize that human beings, though marvelously adaptable, must struggle to cope with an often hostile environment. Environmental Medicine is an integration of concepts drawn from both the primary and specialty care medical fields and the basic sciences. Discovering the cause-and-effect relationships of disease allows a physician to initiate treatment protocols that can result in genuine healing. AAEM
The American Academy of Nerotherapy
is an educational organization that sponsors seminars, some of which focus on
toxicity. They have a doctor referral service.
A project of the National Institute for Science, Law, and Public Policy created to "level the playing field" between the powerful state Dental Boards and all licensed dentists, whether or not mercury-free. Furthermore, CDC has grown to involve Governors, Attorney Generals, and Directors of Health in the fight to allow dentists to practice which ever way within their professional opinion is safe and effective. CDC XIV) Books Available Bio-Probe Inc. has several books pertaining to dental amalgam mercury. They advertise these books on the world wide web at http://www.bioprobe.com. XV) Newsletters A quarterly International DAMS Newsletter is published quarterly. The subscription price is $25.00 per year. Contact DAMS, Inc. The Bio-Probe Newsletter is published bi-monthly. Editorial office is at 5508 Edgewater Dr., Orlando, FL 32810. The subscription price is $65.00 per year for USA and Canadian subscribers, and $85.00 per year for other countries. Postage paid at Orlando. XVI) Other Web Pages Other information can be found at: XVII) Amalgam Related Conventions The next IAOMT and DAMS meeting is scheduled for September 26-28, 2002 at the Sheraton World Resort in Calgary AB Canada. If you are a health care professional, please make reservations through the IAOMT at: IAOMT If you are a DAMS member or would like to join please make reservations at: DAMS, Inc. XVIII) Request for Finincial Support of Web Page The development, operation and expansion of this web page and other DAMS activities are made possible by funding from viewers like you. Please make a $25 to $100 or more donation to DAMS Inc. DAMS Inc. is a 501 (c) (3) organization so all funds that you donate may be used as federal income tax deductions (Federal Tax I.D.# 85-0391003). We thank you in advance for the donations. Please send your donations to: DAMS, Inc. IXX) The Mercury Free and Healthy Campaign (Bumper Sticker Orders) DAMS has developed a bumper sticker titled "Mercury Free and Healthy." It advertises this web page www.amalgam.org. These bumper stickers are available in bundles of 100 for $50US plus shipping cost. Purchases can be made using Visa and Mastercard. They can be ordered from: DAMS, Inc. XX) DAMS PRESS RELEASE XXa) Mercury in Dental Filling Disclosure and Prohibition Act
Statement by Congresswoman Diane
Watson (D-Los Angeles)
In times like these, there are toxins that we don't know much about - how to control them, their source, and their impact. But there are toxins that we DO know about -- toxins that we know do not belong in our bodies, toxins that we can do something about. My bill addresses that very problem. Mercury is an acute neuro-toxin. It is the most toxic non-radioactive element and the most volatile heavy metal. In recent years, it has been, or is being, removed from all health care uses, save one. Antibiotics have replaced oral doses of Mercury. The disinfectant Mercurochrome is banned. Recently, the Centers for Disease Control ordered Mercury preservatives removed from childhood vaccines. Mercury preservatives are no longer used in contact lens solutions. This year, legislatures in California and several other states banned Mercury thermometers. When Governor Gray Davis signed bills addressing Mercury in thermometers and in dental fillings, he said, "Mercury is a persistent and toxic pollutant that bioaccumulates in the environment." In recent years, the American Public Health Association, the California Medical Association, and Health Care Without Harm have all called for the elimination of putting any Mercury in the human body. Today, I am announcing legislation to disclose and phase-out the last major use of Mercury in the human body. The fillings that organized dentistry wrongly calls "silver" are mainly Mercury, not "silver." Mercury is the major ingredient in each filling, about one-half gram per. In the words of Professor Boyd Haley of the University of Kentucky, that is a "colossal" amount of Mercury in scientific terms - as much, in fact, as is in a thermometer. A teenager with six fillings has six Mercury thermometers worth of Mercury in his or her mouth. The Mercury in the fillings is volatile, such that - as all authorities concede - poisonous vapors are constantly being emitted from the fillings, more so when one chews or passes hot liquid over the teeth. The Agency for Toxic Substances & Disease Registry of the United States Public Health Service reports that those poisonous vapors go first to the brain and kidneys. For the developing brain - and by that I mean a child's brain - a major health risk exists. It is in fact children who are at greatest risk from these fillings. The government of Canada recommended back in 1996 that dentists not place fillings in the mouths of children or pregnant women. (The 1999 report on Mercury by the Agency for Toxic Substances & Disease Registry says Mercury passes through the placenta into the developing child's brain.) In 1997, a major manufacturer of dental amalgam, Dentsply, said that amalgam is CONTRAINDICATED (translation: DO NOT USE) for children and pregnant women, as well as for those with braces, Mercury hypersensitivities, or kidney problems. Another manufacturer, Vivadent, added a contraindication for nursing mothers. (That 1999 government report says the Mercury goes through the mother's breast milk into the baby.) Why don't consumers already know this? The answer is a disappointing one. Organized dentistry is extremely divided on this issue. My bill, in fact, is supported by the American Academy of Biological Dentistry. But the American Dental Association tells the public that the fillings are safe. The ADA does not tell the public that it accepts payments from the amalgam manufacturers while it pronounces their product safe. I wish to note that the American Medical Association has a policy prohibiting the organization from taking money for product endorsements. The ADA, by contrast, accepts money from the manufacturers of the products it endorses, which certainly hurts its credibility in my mind. The public does not know about the presence of Mercury and its risks for two reasons. First, the fillings are falsely called "silver." This term is deceptive, because there is much more Mercury than silver in the product. It's time to call it what it is, and quit hiding the large presence of Mercury. Second, the ADA has a rule that gags dentists from talking about the risks of Mercury amalgam, a rule that some dental boards enforce against dentists who call for the elimination of Mercury in dental fillings. I understand that rule is being challenged by dentists in federal court in Maryland based on the First Amendment. Developments in this area have been quite encouraging this year in my state. In 1992, as a state Senator, I wrote a law that required the Dental Board of California to write a "Fact Sheet" about the "risks and efficacies" of dental fillings. My goal was to ensure the public could make informed choices about Mercury dental amalgam. But the Dental Board continued to ignore the law and, in recent years, defy the Davis Administration's insistence that it comply with this law. After an impasse, including the Board refusing to show up for a hearing in Los Angeles on this issue, the Legislature stepped in and shut down the Board. I am told that never before has the California Legislature shut down a board before its Sunset date expired. In January, a new Dental Board will come into existence. A major environmental issue exists here. When removed from a patient's mouth, Mercury amalgam is a hazardous waste, and it is often improperly disposed of. The more Mercury that goes into people's teeth, the more of it that will end up in our water supply. I am delighted, therefore, that San Francisco-based Clean Water Action is supporting my bill, and I look forward to other environmental groups joining us in this effort. The occupational risk is significant. Dental employees are constantly exposed to the vapors. Women in dental offices have lower fecundity (pregnancy) rates, more miscarriages, and more problem births; Mercury exposure is the likely reason. Dentists have the highest suicide rate of any profession; depression leading to suicide is consistent with a diagnosis of Mercury toxicity. Mercury amalgam is dangerous before it is put in the mouth - any dental journal will tell you that - and it is considered hazardous waste after it has been removed. Who can conclusively say it's safe in between, when it is in our bodies? A major social justice, or environmental justice, issue exists here. While the public lacks informed choice, low- and moderate-income people have it worse: they have no choice at all! For families on Medi-Cal, the children get Mercury - or nothing. It is outrageous that low-income Americans are forced to have such a toxic material put in their mouths. I understand that the Rhode Island legislature adopted a law this year to provide choice in insurance plans, and that the state of Maine permits Medicaid children to get alternatives to amalgam - so, yes, we can do it differently. Mercury, and all other poisons in the body, hurt the body's immune system - its ability to withstand diseases and biologically harmful agents. If at any time in our nation's history we need strong immune systems, it is now. The stronger our bodies, the more able we are to fend off biological agents that have so tragically been placed in our midst. My bill will protect children, pregnant women, and nursing mothers immediately - regardless of their income. Henceforth, amalgam will bear warnings that they not be placed in these most vulnerable people. And there will be health warnings for all consumers of amalgam, also immediately. Then, there is a five-year phase out of Mercury amalgam. That will give dentistry plenty of time to shift to alternatives that exist in today's market - resin, porcelain, and gold - or to develop new materials. Dentistry says amalgam is fine because it has been in use for 150 years. This statement makes no scientific sense. We have abandoned other remnants of pre-Civil War medicine, and we have abandoned all other uses of Mercury. It is no longer a question of if, but when, Mercury dental fillings will be history. I say five more years is time enough.
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DISCLAIMER: All information, data, and material contained, presented, or provided here is for general information purposes only and is not to be construed as reflecting the knowledge or opinions of the publisher, and is not to be construed or intended as providing medical or legal advice. The decision whether or not to vaccinate is an important and complex issue and should be made by you, and you alone, in consultation with your health care provider.
Copyright 2012 by Vaccination News, A Non-Profit Corporation. All Rights Reserved. This content may not be copied unless permission in writing from Sandy Gottstein has been obtained. 
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 "A foolish faith in authority is the worst enemy of truth." -- Albert Einstein, letter to a friend, 1901 "I know of no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education." -- Thomas Jefferson, letter to William C. Jarvis, September 28, 1820 "What's the point of vaccination if it doesn't protect you from the unvaccinated?" -- Sandy Gottstein "Who gets to decide what the greater good is and how many will be sacrificed to it?" -- Sandy Gottstein |