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now, who hasn't heard of SARS, or severe acute respiratory syndrome?
The disease is thought to have originated in southern China in November,
but to have been covered up for months by the Chinese government.
As of Friday, according to the World Health Organization, 2,353 people in
16 countries were reported to have the disease, and at least 84 had died —
3.5 percent — mostly from pneumonia. Fears of the disease have led American
health officials to discourage travel to Hong Kong, Vietnam, Singapore and
mainland China — causing havoc among tourists and seriously affecting the
global economy.
In the United States, there were at least 115 suspected cases, 109 in
people who had traveled to affected parts of Asia, and the rest in people
who were exposed to those travelers. As of Friday, no one had died. deaths.
Health workers are now meeting airplanes arriving in the United States from
affected countries, and handing out cards that urge passengers to be on the
lookout for SARS symptoms like cough and fever. Also on Friday, President
Bush signed an executive order allowing the Health and Human Services
secretary to order the forced quarantine of infected individuals.
SARS is the latest in a series of "emerging infectious diseases," a list
of previously unknown illnesses that runs from Lyme disease, to
Legionnaire's disease, hantaviral lung disease, West Nile virus and AIDS.
It is too soon to say how far SARS will spread, but experts say it is an
urgent public health threat. One reason is that unlike the other emerging
diseases, SARS is spread through the air, by coughing and sneezing. In
addition, though some people who died of SARS were elderly or suffering from
underlying illnesses that made them more vulnerable, others were relatively
young and perfectly healthy, and doctors do not understand why they
succumbed.
"A 3.5 percent death rate in the current era, that's notable," said Dr.
William Schaffner, director of the division of infectious diseases at
Vanderbilt University. "This is a new respiratory illness, undefined, and it
has, under certain circumstances, a propensity to spread rapidly, and it had
an immediate international component in terms of spread. In that sense it
has overtones of new influenza outbreaks that have similar kinds of
characteristics, and there it's pretty high up on the urgency list."
One thing that is not clear is whether the death rate really is 3.5
percent. The real rate is uncertain because no one knows how many people are
infected; some may have minor symptoms or none at all. If so, the death rate
may actually be much lower.
Dr. Scott Hammer, chief of the division of infectious diseases at
Columbia Presbyterian Medical Center in Manhattan, said it was worrisome
that the disease could spread quickly through the air via coughing and
sneezing.
"Whenever you have an illness that does that it naturally creates anxiety
in the public and public health authorities, particularly if there is a 3 to
4 percent fatality rate," he said.
BUT so far, experts say, most Americans do not have to worry about
catching the disease. "If you haven't traveled to an affected area or been
exposed to an ill patient, there's no evidence you're at risk at all," said
Dr. James Hughes, director of the National Center for Infectious Diseases at
the Centers for Disease Control and Prevention. At the same time, Dr. Hughes
said, the possibility of a worldwide epidemic cannot be ruled out. The speed
and volume of international travel mean people can unknowingly carry
diseases all over the world even before the incubation period is up.
As to where the virus came from — assuming it is, as suspected, a new
type of coronavirus (a virus that is one of the chief causes of the common
cold) — experts say there are several possibilities. One is that an earlier
coronavirus that did not cause severe illness in people underwent a genetic
shift that made it more virulent. Another is that a coronavirus changed for
the worse by trading genetic material with another virus.
It is also possible that an animal virus "jumped" into humans. Such jumps
are known to occur, occasionally with dire results. A virus and its usual
host may have adapted to each other to coexist. But with a new host, no
truce has been made.
"You haven't had co-evolution of the virus and the host over time," said
Dr. Joshua Lederberg, a microbiologist and a Nobel laureate in medicine.
But a virus that kills its host too quickly may wind up with no place
else to go. "Virulence is kind of a side effect of the aggression a virus
needs to get over the host's defenses and make a foothold," Dr. Lederberg
said. "The virus must earn a living, but it does better to domesticate the
host than to kill it."
A fourth possibility, which scientists consider unlikely, is bioterrorism:
a new virus might have been genetically engineered in a laboratory, and
might then have escaped or been released on purpose.
"There is no evidence for this, but we have to think about it in this day
and age," Dr. Schaffner said.
It is far too early to tell how important SARS will be in the future,
experts said. Dr. Hammer noted that many respiratory illnesses, like the
flu, tend to come and go seasonally, and scientists do not know why.
"Is this here to stay?" he asked. "Will it be a continuous threat, a
seasonal threat? How will it come into the broad spectrum of respiratory
illnesses and infections for the future? Even if it ebbs, we won't know
about this until next year."